{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:08:56Z","timestamp":1772014136545,"version":"3.50.1"},"reference-count":0,"publisher":"The Nencki Institute of Experimental Biology, Polish Academy of Sciences","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Neurobiol. Exp."],"abstract":"<jats:p>Chronic pain conditions are often linked with depression, a common chronic mental health disorder that severely impairs quality of life. This association is particularly present in chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS). CP\/CPPS is a prevalent urological disorder characterized by pelvic pain accompanied by neuropsychiatric comorbidities such as\u00a0 depression, for which underlying pathophysiological mechanisms remain unclear. Recently, anti\u2011inflammatory and neuroprotective effects of carbon monoxide\u2011releasing molecules (CORMs) have been demonstrated. The aim of this study was to investigate whether CO releaser, CORM\u2011A1 could have beneficial effects on depressive\u2011like behavior in an animal model of CP\/CPPS. Adult male Wistar albino rats were divided into four groups (Sham\u2011PBS, Sham\u2011CORM, CP\/CPPS\u2011PBS and CP\/CPPS\u2011CORM), receiving intraprostatic injections of saline or \u03bb\u2011carrageenan, followed by daily treatments with PBS or CORM\u2011A1 for seven days. Pain thresholds were measured by von Frey esthesiometer, while depression\u2011like behaviors were\u00a0 assessed by the forced swimming test (FST). CP\/CPPS rats exhibited mechanical hyperalgesia which has been significantly diminished by CORM\u2011A1 administration. CORM\u2011A1 treatment caused a significant decrease in floating time and a significant increase in swimming time in CP\/CPPS rats compared to those treated with vehicle (CP\/CPPS\u2011PBS group). Correlation analysis showed a significant link between pain threshold and FST floating time as indicator of depressive\u2011like behaviors. These findings suggest that CORM\u2011A1 beneficially modulates pain perception and depressive\u2011like behaviors in CP\/CPPS rats.<\/jats:p>","DOI":"10.55782\/xngw5w23","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:15:43Z","timestamp":1772010943000},"source":"Crossref","is-referenced-by-count":0,"title":["Slow\u2011releasing CO donor CORM\u2011A1 modulates depression\u2011like behavior in experimental model of chronic prostatitis\/chronic pelvic pain syndrome"],"prefix":"10.55782","author":[{"given":"Nikola","family":"\u0160utulovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Medical Physiology \"Richard Burian\", Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neriman","family":"Ezgin","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia; Department of Biotechnology, Institute of Natural and Applied Sciences, Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilija","family":"\u0110juri\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"Gruba\u010d","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Veskovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology \u201cLjubodrag Buba Mihailovic\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du\u0161an","family":"Mladenovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology \u201cLjubodrag Buba Mihailovic\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Dodurga","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Ra\u0161i\u0107-Markovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera","family":"Stanojlovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-444X","authenticated-orcid":true,"given":"Dragan","family":"Hrncic","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34635","published-online":{"date-parts":[[2026,2,20]]},"container-title":["Acta Neurobiologiae Experimentalis"],"original-title":[],"link":[{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2710\/2543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/download\/2710\/2543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:15:44Z","timestamp":1772010944000},"score":1,"resource":{"primary":{"URL":"https:\/\/ane.pl\/index.php\/ane\/article\/view\/2710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.55782\/xngw5w23","relation":{},"ISSN":["1689-0035","0065-1400"],"issn-type":[{"value":"1689-0035","type":"electronic"},{"value":"0065-1400","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,20]]}}}