{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:31:16Z","timestamp":1780677076552,"version":"3.54.1"},"reference-count":32,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2015]]},"DOI":"10.5582\/bst.2015.01121","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T22:04:06Z","timestamp":1447193046000},"page":"342-349","source":"Crossref","is-referenced-by-count":6,"title":["Serum concentrations of Flt-3 ligand in rheumatic diseases"],"prefix":"10.5582","volume":"9","author":[{"given":"Kayo","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Jinnin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikko","family":"Kajihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunari","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritoshi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Ihn","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lyons R, Narain S, Nichols C, Satoh M, Reeves WH. Effective use of autoantibody tests in the diagnosis of systemic autoimmune disease. Ann N Y Acad Sci. 2005; 1050:217-228.","DOI":"10.1196\/annals.1313.023"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Szekanecz Z, Koch AE. Vascular involvement in rheumatic diseases: &apos;vascular rheumatology&apos;. Arthritis Res Ther. 2008; 10:224.","DOI":"10.1186\/ar2515"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Mulligan-Kehoe MJ, Simons M. Vascular disease in scleroderma: Angiogenesis and vascular repair. Rheum Dis Clin North Am. 2008; 34:73-79.","DOI":"10.1016\/j.rdc.2007.12.006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF\/MEK\/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004; 64:7099-7109.","DOI":"10.1158\/0008-5472.CAN-04-1443"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Li LX, Goetz CA, Katerndahl CD, Sakaguchi N, Farrar MA. A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness. J Immunol. 2010; 184:1728-1736.","DOI":"10.4049\/jimmunol.0903023"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Smith JR, Thackray AM, Bujdoso R. Reduced herpes simplex virus type I latency in Flt-3 ligand-treated mice is associated with enhanced numbers of natural killer and dendritic cells. Immunology 2001; 102:352-358.","DOI":"10.1046\/j.1365-2567.2001.01180.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kinn PM, Holdren GO, Westermeyer BA, Abuissa M, Fischer CL, Fairley JA, Brogden KA, Brogden NK. Age-dependent variation in cytokines, chemokines, and biologic analytes rinsed from the surface of healthy human skin. Sci Rep. 2015; 5:e10472.","DOI":"10.1038\/srep10472"},{"key":"8","unstructured":"8. Nakao M, Yokota S, Iwai T, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996; 10:1911-1918."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003; 3:650-665.","DOI":"10.1038\/nrc1169"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tob\u00f3n GJ, Renaudineau Y, Hillion S, Cornec D, Devauchelle-Pensec V, Youinou P, Pers JO. The Fms-like tyrosine kinase 3 ligand, a mediator of B cell survival, is also a marker of lymphoma in primary Sj\u00f6gren&apos;s syndrome. Arthritis Rheum. 2010; 62:3447-3456.","DOI":"10.1002\/art.27611"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ramos MI, Perez SG, Aarrass S, Helder B, Broekstra P, Gerlag DM, Reedquist KA, Tak PP, Lebre MC. FMS-related tyrosine kinase 3 ligand (Flt3L)\/CD135 axis in rheumatoid arthritis. Arthritis Res Ther. 2013; 15:R209.","DOI":"10.1186\/ar4403"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Subcommittee for scleroderma criteria of the American rheumatism association diagnostic and therapeutic criteria committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 1980; 23:581-590.","DOI":"10.1002\/art.1780230510"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40:1725.","DOI":"10.1002\/art.1780400928"},{"key":"14","unstructured":"14. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA, Rowell N, Wollheim F. Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis. J Rheumatol. 1988; 15:202-205."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Maricq HR, Weinrich MC, Keil JE, Smith EA, Harper FE, Nussbaum AI, Leroy EC, McGregor AR, Diat F, Rosal EJ. Prevalence of scleroderma spectrum disorders in the general population of South Carolina. Arthritis Rheum. 1989; 32:998-1006.","DOI":"10.1002\/anr.1780320809"},{"key":"16","unstructured":"16. Maricq HR, Mcgregor AR, Diat F, Smith EA, Maxwell DB, LeRoy EC, Weinrich MC. Major clinical diagnoses found among patients with Raynaud phenomenon from the general population. J Rheumatol. 1990; 17:1171-1176."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ihn H, Sato S, Tamaki T, Soma Y, Tsuchida, Ishibashi Y, Takehara K. Clinical evaluation of scleroderma spectrum disorders using a points system. Arch Dermatol Res. 1992; 284:391-395.","DOI":"10.1007\/BF00372068"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975; 292:344-347.","DOI":"10.1056\/NEJM197502132920706"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975; 292:403-407.","DOI":"10.1056\/NEJM197502202920807"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sontheimer RD. Cutaneous features of classic dermatomyositis and amyopathic dermatomyositis. Curr Opin Rheumatol. 1999; 11:475-482.","DOI":"10.1097\/00002281-199911000-00005"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Alarc\u00f3n-Segovia, D, Delez\u00e9 M, Oria, CV, Sanchez-Guerrero J, G\u00f3mez-Pacheco L, Cabiedes J, Fern\u00e1ndez L, Ponce de Le\u00f3n S. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus a prospective analysis of 500 consecutive patients. Medicine. 1989; 68:353-365.","DOI":"10.1097\/00005792-198911000-00003"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Ihn H, Yamane K, Yazawa N, Kubo M, Fujimoto M, Sato S, Kikuchi K, Tamaki K. Distribution and antigen specificity of anti-U1RNP antibodies in patients with systemic sclerosis. Clin Exp Immunol. 1999; 117:383-387.","DOI":"10.1046\/j.1365-2249.1999.00961.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Papadaki HA, Damianaki A, Pontikoglou C, Pyrovolaki K, Eliopoulos DG, Stavroulaki E, Eliopoulos GD. Increased levels of soluble flt-3 ligand in serum and long-term bone marrow culture supernatants in patients with chronic idiopathic neutropenia. Br J Haematol. 2006; 132:637-639.","DOI":"10.1111\/j.1365-2141.2005.05903.x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Crowson AN, Maqro CM. The role of microvascular injury in the pathogenesis of cutaneous lesions of dermatomyositis. Hum Pathol. 1996; 27:15-19.","DOI":"10.1016\/S0046-8177(96)90132-X"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Dalakas MC. Review: An update on inflammatory and autoimmune myopathies. Neuropathol Appl Neurobiol. 2011; 37:226-242.","DOI":"10.1111\/j.1365-2990.2010.01153.x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Mammen AL. Dermatomyositis and polymyositis: Clinical presentation, autoantibodies, and pathogenesis. Ann NY Acad Sci. 2010; 1184:134-153.","DOI":"10.1111\/j.1749-6632.2009.05119.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Distler O, Distler JHW, Scheid A, Acker T, Hirth A, Rethage J, Michel BA, Gay RE, M\u00fcller-Ladner U, Matucci-Cerinic M, Plate KH, Gassmann M, Gay S. Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res. 2004; 95:109-116.","DOI":"10.1161\/01.RES.0000134644.89917.96"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Jinnin M, Makino T, Kajihara I, Honda N, Makino K, Ogata A, Ihn H. Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis. Br J Dermatol. 2010; 162:751-758.","DOI":"10.1111\/j.1365-2133.2009.09567.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Walker JG, Stirling J, Beroukas D, Dharmapatni K, Haynes DR, Smith MD, Ahern MJ, Roberts-Thomson PJ. Histopathological and ultrastructural features of dermal telangiectasias in systemic sclerosis. Pathology. 2005; 37:220-225.","DOI":"10.1080\/00313020500033262"},{"key":"30","unstructured":"30. Ohta A, Nagai M, Nishina M, Tomimitsu H, Kohsaka H. Age at onset and gender distribution of systemic lupus erythematosus, polymyositis\/dermatomyositis, and systemic sclerosis in Japan. 2013; 23:759-764."},{"key":"31","unstructured":"31. Maldonado ME, Perez M, Pignac-Kobinger J, Marx ET, Tozman EM, Greidinger EL, Hoffman RW. Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US caucasian population. J Rheumatol. 2008; 35:429-437."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell. 2015; 14:421-432.","DOI":"10.1111\/acel.12320"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/9\/5\/9_2015.01121\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T23:21:32Z","timestamp":1498260092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/9\/5\/9_2015.01121\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2015.01121","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}