{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:00:07Z","timestamp":1784782807920,"version":"3.55.0"},"reference-count":99,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2017]]},"DOI":"10.5582\/bst.2017.01216","type":"journal-article","created":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T22:03:57Z","timestamp":1511129037000},"page":"496-506","source":"Crossref","is-referenced-by-count":87,"title":["Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism"],"prefix":"10.5582","volume":"11","author":[{"given":"Jing","family":"Lin","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wenling People\u2019s Hospital, Wenzhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Gober","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kepler University Clinic, Neuromed Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajin","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine of Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","unstructured":"1. Kanis JA. WHO scientific group technical report: Assessment of osteoporosis at the primary health care level. WHO Collaborating Center for Metabolic Bone Diseases, University of Sheffield, UK. 2007."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Gallagher JC, Tella SH. Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol. 2014; 142:155-170.","DOI":"10.1016\/j.jsbmb.2013.09.008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. An J, Yang H, Zhang Q, Liu CC, Zhao JJ, Zhang LL, Chen B. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation. Life Sci. 2016; 147:46-58.","DOI":"10.1016\/j.lfs.2016.01.024"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Xu M, Qi C, Deng B, Deng PX, Mo CW. Phytotherapy versus hormonal therapy for postmenopausal bone loss: A meta-analysis. Osteoporos Int. 2009; 20:519-526.","DOI":"10.1007\/s00198-008-0724-x"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Jin YX, Wu P, Mao YF, Wang B, Zhang JF, Chen WL, Liu Z, Shi XL. Chinese herbal medicine for osteoporosis: A meta-analysis of randomized controlled trials. J Clin Densitom. 2017; doi: 10.1016\/j.jocd.2017.07.003.","DOI":"10.1016\/j.jocd.2017.07.003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Gao Z, Lu Y, Jin J, Xu D. Study of osteoporosis treatment principles used historically by ancient physicians in Chinese medicine. Chin J Integr Med. 2013; 19:862-868.","DOI":"10.1007\/s11655-013-1328-z"},{"key":"7","unstructured":"7. Wang SJ, Li Y, Liu H, Liu ZH. Mechanism underlying osteoporosis: Understanding according to theory of traditional Chinese medicine. World Chin Med. 2013; 8:1044-1048. (in Chinese)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Shu B, Shi Q, Wang YJ. Shen(Kidney)-tonifying principle for primary osteoporosis: To treat both the disease and the Chinese medicine syndrome. Chin J Integr Med. 2015; 21:656-661.","DOI":"10.1007\/s11655-015-2306-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zhang Y, Papasian CJ, Deng HW. Alteration of vitamin D metabolic enzyme expression and calcium transporter abundance in kidney involved in type 1 diabetes-induced bone loss. Osteoporos Int. 2011; 22:1781-1788.","DOI":"10.1007\/s00198-010-1404-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Ma HP, He XR, Yang Y, Li MX, Hao DJ, Jia ZP. The genus Epimedium: An ethnopharmacological and phytochemical review. J Ethnopharmacol. 2011; 134:519-541.","DOI":"10.1016\/j.jep.2011.01.001"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wang LL, Li Y, Guo YB, Ma RF, Fu M, Niu JZ, Gao SH, Zhang DW. Herba Epimedii: An ancient Chinese herbal medicine in the prevention and treatment of osteoporosis. Curr Pharm Des. 2016; 22:328-349.","DOI":"10.2174\/1381612822666151112145907"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Xie F, Wu CF, Lai WP, Yang XJ, Cheung PY, Yao XS, Leung PC, Wong MS. The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. Evid-based Compl Alt. 2005; 2:353-361.","DOI":"10.1093\/ecam\/neh101"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Qian GF, Zhang XZ, Lu LX, Wu XJ, Li SM, Meng J. Regulation of Cbfa 1 expression by total flavonoids of Herba Epimedii. Endocr J. 2006; 53:87-94.","DOI":"10.1507\/endocrj.53.87"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Chen WF, Mok SK, Wang XL, Lai KH, Lai WP, Luk HK, Leung PC, Yao XS, Wong MS. Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice. Br J Nutr. 2011; 105:180-189.","DOI":"10.1017\/S0007114510003247"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine. 2009; 16:320-326.","DOI":"10.1016\/j.phymed.2008.12.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Li GW, Xu Z, Chang SX, Nian H, Wang XY, Qin LD. Icariin prevents ovariectomy-induced bone loss and lowers marrow adipogenesis. Menopause. 2014; 21:1007-1016.","DOI":"10.1097\/GME.0000000000000201"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Xue L, Jiang Y, Han T, Zhang N, Qin L, Xin H, Zhang Q. Comparative proteomic and metabolomic analysis reveal the antiosteoporotic molecular mechanism of icariin from Epimedium brevicornu maxim. J Ethnopharmacol. 2016; 192:370-381.","DOI":"10.1016\/j.jep.2016.07.037"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Zhao BJ, Wang J, Song J, Wang CF, Gu JF, Yuan JR, Zhang L, Jiang J, Feng L, Jia XB. Beneficial effects of a flavonoid fraction of Herba Epimedii on bone metabolism in ovariectomized rats. Planta Med. 2016; 82:322-329.","DOI":"10.1055\/s-0035-1558294"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Nian H, Xu LL, Ma MH, Qin LP, Zheng HC, Zhang QY. Prevention of bone loss by aqueous extract of Epimedii sagittatum in an ovariectomized rat model of osteoporosis. J Chin Integr Med. 2006; 4:628-633.","DOI":"10.3736\/jcim20060618"},{"key":"20","unstructured":"20. Wu MS, Zhao SZ, Ren LZ, Wang R, Bai X, Han HW, Li B. Experimental study on effect of anhydroicaritin phytosomes in preventing and treating bone loss and enhancing bone quality in ovariectomized osteoporosis rats. China J Chin Materia Medica. 2013; 38:2163-2168. (in Chinese)"},{"key":"21","unstructured":"21. Qin L, Zhang G, Wang XL, Shi YY, Kong YY, Yang XE, Sheng H, Liang BZ, Liang GS, Yao XS. Epimedium-derived flavonoids prevent ovariectomy-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption. Natl Med J China. 2008; 88:1772-1777. (in Chinese)"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Zhang G, Qin L, Hung WY, Shi YY, Leung PC, Yeung HY, Leung KS. Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption. Bone. 2006; 38:818-825.","DOI":"10.1016\/j.bone.2005.11.019"},{"key":"23","unstructured":"23. Wu M, Zhao S, Ren L. Effects of total flavonoids of Epimedium sagittatum on the mRNA expression of the estrogen receptor alpha and beta in hypothalamus and hippocampus in ovariectomized rats. J Cent South Univ (Med Sci). 2011; 36:15-20."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Mok S, Chen W, Lai W, Leung P, Wang X, Yao X, Wong M.Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. Br J Pharmacol. 2010; 159:939-949.","DOI":"10.1111\/j.1476-5381.2009.00593.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Chen G, Wang C, Wang J, Yin S, Gao H, Xiang LU, Liu H, Xiong Y, Wang P, Zhu X, Yang LI, Zhang R. Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt\/beta-catenin pathway. Exp Ther Med. 2016; 12:279-287.","DOI":"10.3892\/etm.2016.3333"},{"key":"26","unstructured":"26. Li XF, Xu H, Zhao YJ, Tang DZ, Xu GH, Holz J, Wang J, Cheng SD, Shi Q, Wang YJ. Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt\/ beta -Catenin-BMP Signaling. Evid-based Compl Alt. 2013; 2013:652317."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Peng S, Zhang G, Zhang B, Guo B, He Y, Bakker AJ, Pan X, Zhen W, Hung L, Qin L, Leung W. The beneficial effect of Icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats. Bone. 2013; 55:230-240.","DOI":"10.1016\/j.bone.2013.02.012"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Zhang JF, Li G, Chan CY, Meng CL, Lin MC, Chen YC, He ML, Leung PC, Kung HF. Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt\/beta-catenin signaling pathway. Mol Cell Endocrinol. 2010; 314:70-74.","DOI":"10.1016\/j.mce.2009.08.012"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Wang R, Luo J, Kong L. An MC3T3-E1 cell line biomembrane extraction and HPLC-ESI-MS (n) method for simultaneous analysis of potential anti-osteoporosis components of Epimedium koreanum. Chromatographia. 2012; 75:607-615.","DOI":"10.1007\/s10337-012-2232-6"},{"key":"30","unstructured":"30. Wu H, Zha ZG, Yao P. Experimental study of icariin in inducing bone marrow mesenchymal stem cell differentiation. Chin J Integr Tradit West Med. 2010; 30:410-415. (in Chinese)"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ma HP, Ming LG, Ge BF, Zhai YK, Song P, Xian CJ, Chen KM. Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro. J Cell Biochem. 2011; 112:916-923.","DOI":"10.1002\/jcb.23007"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Xiao Q, Chen A, Guo F. Effects of Icariin on expression of OPN mRNA and type I collagen in rat osteoblasts in vitro. J Huazhong Univ Sci Technolog Med Sci. 2005; 25:690-692.","DOI":"10.1007\/BF02896172"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hsieh T, Sheu S, Sun J, Chen M, Liu M. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomedicine. 2010; 17:414-423.","DOI":"10.1016\/j.phymed.2009.08.007"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Liang W, Lin M, Li X, Li C, Gao B, Gan H, Yang Z, Lin X, Liao L, Yang M. Icariin promotes bone formation via the BMP-2\/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line. Int J Mol Med. 2012; 30:889-895.","DOI":"10.3892\/ijmm.2012.1079"},{"key":"35","unstructured":"35. Cao H, Ke Y, Zhang Y, Zhang CJ, Qian W, Zhang GL. Icariin stimulates MC3T3-E1 cell proliferation and differentiation through up-regulation of bone morphogenetic protein-2. Int J Mol Med. 2012; 29:435-439."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Zhai Y, Guo X, Ge B, Zhen P, Ma X, Zhou J, Ma H, Xian CJ, Chen K. Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG. BONE. 2014; 66:189-198.","DOI":"10.1016\/j.bone.2014.06.016"},{"key":"37","unstructured":"37. Chen KM, Ge BF, Ma HP, Liu XY, Bai MH, Wang Y. Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. Pharmazie. 2005; 60:939-942."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Wei Q, Zhang J, Hong G, Chen Z, Deng W, He W, Chen MH. Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERalpha-Wnt\/beta-catenin signaling pathway. Biomed Pharmacother. 2016; 84:931-939.","DOI":"10.1016\/j.biopha.2016.09.107"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Xiao HH, Fung CY, Mok SK, Wong KC, Ho MX, Wang XL, Yao XS, Wong MS. Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERalpha) and stimulate ER-dependent osteoblastic functions in UMR-106 cells. J Steroid Biochem Mol Biol. 2014; 143:141-51.","DOI":"10.1016\/j.jsbmb.2014.02.019"},{"key":"40","unstructured":"40. Liu M, Xu H, Ma Y, Cheng J, Hua Z, Huang G. Osteoblasts proliferation and differentiation stimulating activities of the main components of epimedii folium. Pharmacogn Mag. 2017; 13:90-94."},{"key":"41","unstructured":"41. Liu HQ, Qin JJ, Wu Q. Effect of herb epimedii on expression of PPAR gamma mRNA of MSCs during adipogenesis in postmenopausal osteoporosis rats. Tradit Chin Drug Res Clin Pharm. 2013; 24:382-385. (in Chinese)"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Xu YX, Xu B, Wu CL, Wu Y, Tong PJ, Xiao LW. Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats. Orthop Surg. 2011; 3:119-126.","DOI":"10.1111\/j.1757-7861.2011.00129.x"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Xu YX, Wu CL, Wu Y, Tong PJ, Jin HT, Yu NZ, Xiao LW. Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt\/beta-catenin signal pathway activation. Chin J Integr Med. 2012; 18:909-917.","DOI":"10.1007\/s11655-012-1294-2"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Zhang S, Feng P, Mo G, Li D, Li Y, Mo L, Yang Z, Liang. Icariin influences adipogenic differentiation of stem cells affected by osteoblast-osteoclast co-culture and clinical research adipogenic. Biomed Pharmacother. 2017; 88:436-442.","DOI":"10.1016\/j.biopha.2017.01.050"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Hsieh T, Sheu S, Sun J, Chen M. Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs\/NF-kappa B regulated HIF-1 alpha and PGE2 synthesis. Phytomedicine. 2011; 18:176-185.","DOI":"10.1016\/j.phymed.2010.04.003"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Zhang JF, Li G, Meng CL, Dong Q, Chan CY, He ML, Leung PC, Zhang YO, Kung HF. Total flavonoids of Herba Epimedii improves osteogenesis and inhibits osteoclastogenesis of human mesenchymal stem cells. Phytomedicine. 2009; 16:521-529.","DOI":"10.1016\/j.phymed.2009.01.003"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Liu YQ, Yang QX, Cheng MC, Xiao HB. Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth. Phytomedicine. 2014; 21:1633-1637.","DOI":"10.1016\/j.phymed.2014.07.016"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Zhang D, Zhang J, Fong C, Yao X, Yang M. Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2\/M arrest and apoptosis. Biochimie. 2012; 94:2514-2522.","DOI":"10.1016\/j.biochi.2012.06.033"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Ma HP, Ma XN, Ge BF, Zhen P, Zhou J, Gao YH, Xian CJ, Chen KM. Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potential in vitro. Cell Prolif. 2014; 47:527-539.","DOI":"10.1111\/cpr.12147"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Wu Y, Xia L, Zhou Y, Xu Y, Jiang X. Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK-dependent manner. Cell Prolif. 2015; 48:375-384.","DOI":"10.1111\/cpr.12185"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Song LG, Zhao JS, Zhang XZ, Li H, Zhou Y. Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation. Eur J Pharmacol. 2013; 714:15-22.","DOI":"10.1016\/j.ejphar.2013.05.039"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Li M, Zhang ND, Wang Y, Han T, Jiang YP, Rahman K, Qin LP, Xin HL, Zhang QY. Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and osteoblasts in neonatal rat calvaria cultures. J Ethnopharmacol. 2016; 185:120-131.","DOI":"10.1016\/j.jep.2016.03.023"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Bian Q, Huang JH, Liu SF, Ning Y, Yang Z, Zhao YJ, Shen ZY, Wang YJ. Different molecular targets of icariin on bMSCs in CORT and OVX-rats. Front Biosci (Elite Ed). 2012; 4:1224-1236.","DOI":"10.2741\/e453"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Qiao X, Lin XH, Liang YH, Dong J, Guo DA, Ye M. Comprehensive chemical analysis of the rhizomes of Drynaria fortunei by orthogonal pre-separation and liquid chromatography mass spectrometry. Planta Med. 2014; 80:330-336.","DOI":"10.1055\/s-0033-1360362"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Zhang YL, Jiang JJ, Shen H, Chai Y, Wei X, Xie YM. Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: Implication in clinical practice. Drug Des Devel Ther. 2017; 11:1881-1890.","DOI":"10.2147\/DDDT.S139804"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Wang XL, Wang NL, Zhang Y, Gao H, Pang WY, Wong MS, Zhang G, Qin L, Yao XS. Effects of eleven flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J. SM. on osteoblastic proliferation using an osteoblast-like cell line. Chem Pharm Bull (Tokyo). 2008; 56:46-51.","DOI":"10.1248\/cpb.56.46"},{"key":"57","unstructured":"57. He WT, Zhou JX, Ding XH, Wang HF, Liang B. Experimental study of drynaria fortunei J. SM for the prevention of postmenopausal osteoporosis. Chin J Osteoporos. 2012; 444-446+457. (in Chinese)"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Wong KC, Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone. Br J Nutr. 2013; 110:475-485.","DOI":"10.1017\/S0007114512005405"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Li N, Jiang Y, Wooley PH, Xu Z, Yang SY. Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. J Orthop Sci. 2013; 18:478-485.","DOI":"10.1007\/s00776-013-0362-9"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Li F, Sun X, Ma J, Ma X, Zhao B, Zhang Y, Tian P, Li Y, Han Z. Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway. Biochem Biophys Res Commun. 2014; 452:629-635.","DOI":"10.1016\/j.bbrc.2014.08.117"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Song N, Zhao Z, Ma X, Sun X, Ma J, Li F, Sun L, Lv J. Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF\/VEGFR-2 signaling pathway in osteoporotic rats. Chem Biol Interact. 2017; 261:11-17.","DOI":"10.1016\/j.cbi.2016.10.020"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Jeong J, Lee J, Yoon C, Kim H, Kim C. Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1. Toxicol in Vitro. 2004; 18:829-834.","DOI":"10.1016\/j.tiv.2004.05.002"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Jeong JC, Lee JW, Yoon CH, Lee YC, Chung KH, Kim MG, Kim CH. Stimulative effects of Drynariae Rhizoma extracts on the proliferation and differentiation of osteoblastic MC3T3-E1 cells. J Ethnopharmacol. 2005; 96:489-495.","DOI":"10.1016\/j.jep.2004.09.038"},{"key":"64","unstructured":"64. Zhai YK, Niu YB, Pan YL, Li CR, Wu XL, Mei QB. Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro. China J Chin Materia Medica. 2013; 38:105-111. (in Chinese)"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Zhang P, Dai KR, Yan SG, Yan WQ, Zhang C, Chen DQ, Xu B, Xu ZW. Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells. Eur J Pharmacol. 2009; 607:1-5.","DOI":"10.1016\/j.ejphar.2009.01.035"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Chen L, Lei L, Ding P, Tang Q, Wu Y. Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. Arch Oral Biol. 2011; 56:1655-1662.","DOI":"10.1016\/j.archoralbio.2011.06.008"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Chang EJ, Lee WJ, Cho SH, Choi SW. Proliferative effects of flavan-3-ols and propelargonidins from rhizomes of Drynaria fortunei on MCF-7 and osteoblastic cells. Arch Pharm Res. 2003; 26:620-630.","DOI":"10.1007\/BF02976711"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Wang X, Zhen L, Zhang G, Wong MS, Qin L, Yao X. Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei--an in vitro efficacy study. Phytomedicine. 2011; 18:868-872.","DOI":"10.1016\/j.phymed.2011.01.022"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Li L, Zeng Z, Cai G. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. Phytomedicine. 2011; 18:985-989.","DOI":"10.1016\/j.phymed.2011.03.002"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Yu GY, Zheng GZ, Chang B, Hu QX, Lin FX, Liu DZ, Wu CC, Du SX, Li XD. Naringin stimulates osteogenic differentiation of rat bone marrow stromal cells via activation of the Notch signaling pathway. Stem Cells Int. 2016; 2016:7130653.","DOI":"10.1155\/2016\/7130653"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Huang ZM, Ouyang GL, Xiao LB, Li NL, Gao HL, He Y, Huang Z, Huang XX. Effects of Drynaria total flavonoids on apoptosis of osteoblasts mediated by tumor necrosis factor-alpha. J Chin Integr Med. 2011; 9:173-178. (in Chinese)","DOI":"10.3736\/jcim20110210"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Liu M, Li Y, Yang S. Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid-derived stem cells. J Tissue Eng Regen Med. 2017; 11:276-284.","DOI":"10.1002\/term.1911"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Qiu ZC, Dong XL, Dai Y, Xiao GK, Wang XL, Wong KC, Wong MS, Yao XS. Discovery of a new class of Cathepsin K inhibitors in Rhizoma Drynariae as potential candidates for the treatment of osteoporosis. Int J Mol Sci. 2016; 17:2116-2134.","DOI":"10.3390\/ijms17122116"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Sun J, Dong G, Lin C, Sheu S, Lin F, Chen L, Chang WH, Wang Y. The effect of Gu-Sui-Bu (Drynaria fortunei J. Sm) immobilized modified calcium hydrogenphosphate on bone cell activities. Biomaterials. 2003; 24:873-882.","DOI":"10.1016\/S0142-9612(02)00372-1"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Jeong J, Lee B, Yoon C, Kim H, Kim C. Effects of Drynariae rhizoma on the proliferation of human bone cells and immunomodulatory activity. Pharmacol Res. 2005; 51:125-136.","DOI":"10.1016\/j.phrs.2004.06.005"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Jeong J, Kang S, Youn C, Jeong C, Kim H, Lee Y, Chang Y, Kim C. Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts. Int Immunopharmacol. 2003; 3:1685-1697.","DOI":"10.1016\/j.intimp.2003.08.003"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Jeong JC, Yoon CH, Jeong CW, Lee YC, Chang YC, Kim CH. Inhibitory activity of Drynariae rhizoma extracts on cathepsin having bone resorption activity. Immunopharmacol Immunotoxicol. 2004; 26:373-385.","DOI":"10.1081\/IPH-200026879"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Guo YB, Li Y, Xue LM, Severino RP, Gao SH, Niu JZ, Qin LP, Zhang DW, Br\u00f6mme D. Salvia miltiorrhiza: An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs. J Ethnopharmacol. 2014; 155:1401-1416.","DOI":"10.1016\/j.jep.2014.07.058"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Chae HJ, Chae SW, Yun DH, Keum KS, Yoo SK, Kim HR. Prevention of bone loss in ovariectomized rats: The effect of Salvia miltiorrhiza extracts. Immunopharm Immunot. 2004; 26:135-144.","DOI":"10.1081\/IPH-120029951"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Cui Y, Bhandary B, Marahatta A, Lee GH, Li B, Kim DS, Chae SW, Kim HR, Chae HJ. Characterization of Salvia Miltiorrhiza ethanol extract as an anti-osteoporotic agent. BMC Complement Altern Med. 2011; 11:120-130.","DOI":"10.1186\/1472-6882-11-120"},{"key":"81","unstructured":"81. Cui L, Wu T, Liu YY, Deng YF, Ai CM, Chen HQ. Tanshinone prevents cancellous bone loss induced by ovariectomy in rats. Acta Pharmacol Sin. 2004; 25:678-684."},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Kim HK, Woo ER, Lee HW, Park HR, Kim HN, Jung YK, Choi JY, Chae SW, Kim HR, Chae HJ. The correlation of Salvia miltiorrhiza extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone. Immunopharm Immunot. 2008; 30:347-364.","DOI":"10.1080\/08923970801949133"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Lee SY, Choi DY, Woo ER. Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza Bunge. Arch Pharm Res. 2005; 28:909-913.","DOI":"10.1007\/BF02973876"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Yang Y, Su Y, Wang D, Chen Y, Wu T, Li G, Sun X, Cui L.Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt\/FoxO3a signaling. Oxid Med Cell Longev. 2013; 2013:351895.","DOI":"10.1155\/2013\/351895"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Cui L, Liu YY, Wu T, Ai CM, Chen HQ. Osteogenic effects of D+beta-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats. Acta Pharmacol Sin. 2009; 30:321-332.","DOI":"10.1038\/aps.2009.9"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Chin A, Yang YQ, Chai L, Wong RWK, Rabie ABM. Effects of medicinal herb Salvia Miltiorrhiza on osteoblastic cells in vitro. J Orthop Res. 2011; 29:1059-1063.","DOI":"10.1002\/jor.21376"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Xu D, Xu L, Zhou C, Lee WY, Wu T, Cui L, Li G. Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway. Int J Biochem Cell Biol. 2014; 51:1-9.","DOI":"10.1016\/j.biocel.2014.03.005"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Lee S. Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1. Exp Mol Med. 2006; 38:256-264.","DOI":"10.1038\/emm.2006.31"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Nicolin V, Dal Piaz F, Nori SL, Narducci P, De Tommasi N.Inhibition of bone resorption by Tanshinone VI isolated from Salvia miltiorrhiza Bunge. Eur J Histochem. 2010; 54:e21.","DOI":"10.4081\/ejh.2010.e21"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Kim HH, Kim JH, Kwak HB, Huang H, Han SH, Ha H, Lee SW, Woo ER, Lee ZH. Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge. Biochem Pharmacol. 2004; 67:1647-1656.","DOI":"10.1016\/j.bcp.2003.12.031"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Lu CN, Yuan ZG, Zhang XL, Yan R, Zhao YQ, Liao M, Chen JX. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-kappaB signaling pathway. Int Immunopharmacol. 2012; 14:121-126.","DOI":"10.1016\/j.intimp.2012.06.010"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Zhou C, Liu WG, He W, Wang HB, Chen QQ, Song HP. Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-kappaB and MAPK pathways. Int Immunopharmacol. 2015; 25:49-54.","DOI":"10.1016\/j.intimp.2015.01.010"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Li J, Hao LY, Wu JH, Zhang JQ, Su JS. Linarin promotes osteogenic differentiation by activating the BMP-2\/RUNX2 pathway via protein kinase A signaling. Int J Mol Med. 2016; 37:901-910.","DOI":"10.3892\/ijmm.2016.2490"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Yang XL, Li F, Yang YN, Shen JY, Zou R, Zhu PP, Zhang CF, Yang ZL, Li P. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013; 2013:926928.","DOI":"10.1155\/2013\/926928"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Sun H, Li LJ, Zhang AH, Zhang N, Lv HT, Sun WJ, Wang XJ. Protective effects of sweroside on human MG-63 cells and rat osteoblasts. Fitoterapia. 2013; 84:174-179.","DOI":"10.1016\/j.fitote.2012.11.010"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Tang DZ, Yang F, Yang Z, Huang J, Shi Q, Chen D, Wang YJ. Psoralen stimulates osteoblast differentiation through activation of BMP signaling. Biochem Biophys Res Commun. 2011; 405:256-261.","DOI":"10.1016\/j.bbrc.2011.01.021"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Yoon HY, Yun SI, Kim BY, Jin Q, Woo ER, Jeong SY, Chung YS. Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells. Eur J Pharmacol. 2011; 664:54-59.","DOI":"10.1016\/j.ejphar.2011.04.047"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Xiao HH, Gao QG, Zhang Y, Wong KC, Dai Y, Yao XS, Wong MS. Vanillic acid exerts oestrogen-like activities in osteoblast-like UMR 106 cells through MAP kinase (MEK\/ERK)-mediated ER signaling pathway. J Steroid Biochem Mol Biol. 2014; 144:382-391.","DOI":"10.1016\/j.jsbmb.2014.08.002"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Tang DZ, Hou W, Zhou Q, Zhang M, Holz J, Sheu TJ, Li TF, Cheng SD, Shi Q, Harris SE, Chen D, Wang YJ. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010; 25:1234-1245.","DOI":"10.1002\/jbmr.21"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/11\/5\/11_2017.01216\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:39:14Z","timestamp":1750999154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/11\/5\/11_2017.01216\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2017.01216","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}