{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:10:56Z","timestamp":1782792656972,"version":"3.54.5"},"reference-count":90,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2019,4,30]]},"DOI":"10.5582\/bst.2018.01298","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T22:02:15Z","timestamp":1553983335000},"page":"117-129","source":"Crossref","is-referenced-by-count":16,"title":["Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review"],"prefix":"10.5582","volume":"13","author":[{"given":"Zengshu","family":"Huang","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Pan","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Ting","family":"Leung","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University"},{"name":"The Academy of Integrative Medicine, Fudan University"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Passioti M, Maggina P, Megremis S, Papadopoulos NG. The common cold: Potential for future prevention or cure. Curr Allergy Asthma Rep. 2014; 14:413.","DOI":"10.1007\/s11882-013-0413-5"},{"key":"2","unstructured":"2. China: Expert consensus on the standardization of common cold medicines for special populations. International Journal of Respiration. 2015;35:1-5. (in Chinese)"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Chen W, Liu B, Wang LQ, Ren J, Liu JP. Chinese patent medicines for the treatment of the common cold: A systematic review of randomized clinical trials. BMC Complementary Altern Med. 2014; 14:273-280.","DOI":"10.1186\/1472-6882-14-273"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Li T, Peng T. Traditional Chinese herbal medicine as a source of molecules with antiviral activity. Antiviral Res. 2013; 97:1-9.","DOI":"10.1016\/j.antiviral.2012.10.006"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Gamaleldin Elsadig Karar M, Matei MF, Jaiswal R, Illenberger S, Kuhnert N. Neuraminidase inhibition of dietary chlorogenic acids and derivatives - Potential antivirals from dietary sources. Food Funct. 2016; 7:2052-2059.","DOI":"10.1039\/C5FO01412C"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hour MJ, Huang SH, Chang CY, Lin YK, Wang CY, Chang YS, Lin CW. Baicalein, ethyl acetate, and chloroform extracts of Scutellaria baicalensis inhibit the neuraminidase activity of pandemic 2009 H1N1 and seasonal influenza A viruses. Evid Based Complement Alternat Med. 2013; 2013:750-803.","DOI":"10.1155\/2013\/750803"},{"key":"7","unstructured":"7. Tu B, Nie W, Ding PP, Li FY, Chen WW, Zhou ZP, Zhang X, Fan R, Huo DD, Zhao M. Efficacy of treatment of influenza A (H1N1) with oseltamivir phosphate and isatis root granules. Medical Journal of the Chinese People&apos;s Armed Police Forces. 2013; 24:465-467+470. (in Chinese)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yang Z, Wang Y, Zheng Z, Zhao S, Zhao J, Lin Q, Li C, Zhu Q, Zhong N. Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses <i>in vitro<\/i>. Int J Mol Med. 2013; 31:867-873.","DOI":"10.3892\/ijmm.2013.1274"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Xiong J, Li S, Wang W, Hong Y, Tang K, Luo Q. Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves. Food Chem. 2013; 138:327-333.","DOI":"10.1016\/j.foodchem.2012.10.127"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Shan B, Cai YZ, Brooks JD, Corke H. The <i>in vitro<\/i> antibacterial activity of dietary spice and medicinal herb extracts. Int J Food Microbiol. 2007; 117:112-119.","DOI":"10.1016\/j.ijfoodmicro.2007.03.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kao ST, Liu CJ, Yeh CC. Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation. J Ethnopharmacol. 2015; 168:108-115.","DOI":"10.1016\/j.jep.2015.03.012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Wang Z, Xia Q, Liu X, Liu W, Huang W, Mei X, Luo J, Shan M, Lin R, Zou D, Ma Z. Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. J Ethnopharmacol. 2018; 210:318-339.","DOI":"10.1016\/j.jep.2017.08.040"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Li YH, Zheng FJ, Huang Y, Zhong XG, Guo MZ. Synergistic anti-inflammatory effect of Radix Platycodon in combination with herbs for cleaning-heat and detoxification and its mechanism. Chin J Integr Med. 2013; 19:29-35.","DOI":"10.1007\/s11655-011-0763-6"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Roth J, Blatteis CM. Mechanisms of fever production and lysis: Lessons from experimental LPS fever. Compr Physiol. 2014; 4:1563-1604.","DOI":"10.1002\/cphy.c130033"},{"key":"15","unstructured":"15. Jin GT, Li B, Wang SR. Experimental study on material basis, efficacy and mechanism of antipyretic effect of Bupleuri Radix. Journal of Chengdu University of Traditional Chinese Medicine. 2013; 36:28-30. (in Chinese)"},{"key":"16","unstructured":"16. Qin XJ, Ma C. Experimental study on pyretolysis mechanism of compatible application of Folium Mori and Flos Chrysanthemi. Journal of New Chinese Medicine. 2013; 45:133-135."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kiyohara H, Nagai T, Munakata K, Nonaka K, Hanawa T, Kim SJ, Yamada H. Stimulating effect of Japanese herbal (kampo) medicine, hochuekkito on upper respiratory mucosal immune system. Evid Based Complement Alternat Med. 2006; 3:459-467.","DOI":"10.1093\/ecam\/nel030"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Yan Y, Chai CZ, Wang DW, Yue XY, Zhu DN, Yu BY. HPLC-DAD-Q-TOF-MS\/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction. J Pharm Biomed Anal. 2013; 80:192-202.","DOI":"10.1016\/j.jpba.2013.03.008"},{"key":"19","unstructured":"19. Song HN, Mao ZF, Han DF, Xiang N, Li RL. Randomized double-blind controlled trial on Gegentang mixture in treatment of cold. Clinical Focus. 2005; 20:313-315."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kitamura H, Urano H, Ara T. Preventive effects of a Kampo medicine, Kakkonto, on inflammatory responses via the suppression of extracellular signal-regulated kinase phosphorylation in lipopolysaccharide-treated human gingival fibroblasts. ISRN Pharmacol. 2014; 2014:1-7.","DOI":"10.1155\/2014\/784019"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wu CT, Tzeng JN, Lai JN, Tsan SH, Wang JD. Prescription profile of Chinese herbal products containing coumestrol, genestein, and\/or daidzein among female users: An analysis of national health insurance data in Taiwan between 1997 and 2007. Chin Med. 2012; 7:22.","DOI":"10.1186\/1749-8546-7-22"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chang JS, Wang KC, Shieh DE, Hsu FF, Chiang LC. Ge-Gen-Tang has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J Ethnopharmacol. 2012; 139:305-310.","DOI":"10.1016\/j.jep.2011.11.018"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Wu MS, Yen HR, Chang CW, Peng TY, Hsieh CF, Chen CJ, Lin TY, Horng JT. Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase\/Akt signaling pathway and viral RNP nuclear export. J Ethnopharmacol. 2011; 134:614-623.","DOI":"10.1016\/j.jep.2011.01.005"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Cheng HM, Li CC, Chen CY, Lo HY, Cheng WY, Lee CH, Yang SZ, Wu SL, Hsiang CY, Ho TY. Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation. J Ethnopharmacol. 2010; 132:429-437.","DOI":"10.1016\/j.jep.2010.08.022"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Zhang H, Chen Q, Zhou W, Gao S, Lin H, Ye S, Xu Y, Cai J. Chinese medicine injection shuanghuanglian for treatment of acute upper respiratory tract infection: A systematic review of randomized controlled trials. Evid Based Complement Alternat Med. 2013; 2013:987-326.","DOI":"10.1155\/2013\/987326"},{"key":"26","unstructured":"26. Shen SY, Liu JH, Tian YR, Guo J, Feng JZ, Liu SD, Zeng XJ, Dong XH, Long M. Antiviral activity of shuanghuanglian tablet against influenza A1 virus FM1 and adenovirus ADV3 in mice. China Practical Medicine. 2008; 3:50-52."},{"key":"27","unstructured":"27. Wu JR, Zhang D, Zhang XM, Zhang B. Systematic review of Shuanghuanglian injection in the treatment of acute upper respiratory infection. Chinese Journal of Pharmacoepidemiology. 2016; 25:269-274. (in Chinese)"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ma Q, Liang D, Song S, Yu Q, Shi C, Xing X, Luo JB. Comparative study on the antivirus activity of Shuang-Huang-Lian injectable powder and its bioactive compound mixture against human adenovirus III <i>in vitro<\/i>. Viruses. 2017; 9:79-91.","DOI":"10.3390\/v9040079"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fang L, Gao Y, Liu F, Hou R, Cai RL, Qi Y. Shuang-huang-lian attenuates lipopolysaccharide-induced acute lung injury in mice involving anti-inflammatory and antioxidative activities. Evid Based Complement Alternat Med. 2015; 2015:283939.","DOI":"10.1155\/2015\/283939"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wang J, Li FW, Zeng KZ, Li Q, Zhao XF, Zheng XH. Bioactive compounds of Shuang-Huang-Lian prescription and an insight into its binding mechanism by beta2 -adrenoceptor chromatography coupled with site-directed molecular docking. J Sep Sci. 2017; 40:4357-4365.","DOI":"10.1002\/jssc.201700522"},{"key":"31","unstructured":"31. Ma CH, Ma ZQ, Fu Q, Ma SP. Ma Huang Tang ameliorates asthma though modulation of Th1\/Th2 cytokines and inhibition of Th17 cells in ovalbumin-sensitized mice. Chin J Nat Med. 2014; 12:361-366."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Wang JW, Chiang MH, Lu CM, Tsai TH. Determination the active compounds of herbal preparation by UHPLC-MS\/MS and its application on the preclinical pharmacokinetics of pure ephedrine, single herbal extract of Ephedra, and a multiple herbal preparation in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016; 1026:152-161.","DOI":"10.1016\/j.jchromb.2015.12.027"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Wang C, Cao B, Liu QQ, <i>et al<\/i>. Oseltamivir compared with the Chinese traditional therapy maxingshigan-yinqiaosan in the treatment of H1N1 influenza: A randomized trial. Ann Intern Med. 2011; 155:217-225.","DOI":"10.7326\/0003-4819-155-4-201108160-00005"},{"key":"34","unstructured":"34. Hu JM, Yan JY, Cheng GZ, Wang HH, Feng CB, Zhao AX. Clinical research for Maxingshigan decoction on treating pregnancy influenza. Chinese Medicine Modern Distance Education of China. 2012; 10:80-81. (in Chinese)"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Hsieh CF, Lo CW, Liu CH, Lin S, Yen HR, Lin TY, Horng JT. Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. J Ethnopharmacol. 2012; 143:57-67.","DOI":"10.1016\/j.jep.2012.05.061"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Lin YC, Chang CW, Wu CR. Antitussive, anti-pyretic and toxicological evaluation of Ma-Xing-Gan-Shi-Tang in rodents. BMC Complement Altern Med. 2016; 16:456-464.","DOI":"10.1186\/s12906-016-1440-2"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Ma LQ, Pan CS, Yang N, Liu YY, Yan L, Sun K, Wei XH, He K, Xiao MM, Fan JY, Han JY. Posttreatment with Ma-Xing-Shi-Gan-Tang, a Chinese medicine formula, ameliorates lipopolysaccharide-induced lung microvessel hyperpermeability and inflammatory reaction in rat. Microcirculation. 2014; 21:649-663.","DOI":"10.1111\/micc.12144"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Tao Z, Meng X, Han YQ, Xue MM, Wu S, Wu P, Yuan Y, Zhu Q, Zhang TJ, Wong CCL. Therapeutic mechanistic studies of ShuFengJieDu capsules in an acute lung injury animal model using quantitative proteomics technology. J Proteome Res. 2017; 16:4009-4019.","DOI":"10.1021\/acs.jproteome.7b00409"},{"key":"39","unstructured":"39. Xu YL, Zhang HH, Xue YL, YANG JS, Zhou XM, Mao B, Fan FY, Jin WL, Liu FY, Tian ZJ, Xing ZH. Phase IV clinical trial of Shufeng Jiedu Capsules in the treatment of 2031 cases of acute upper respiratory infection of wind-heat syndrome. China Journal of Traditional Chinese Medicine and Pharmacy. 2016; 32:353-355. (in Chinese)"},{"key":"40","unstructured":"40. Yang X, Yang XW. Observation on efficacy of Shufengjiedu capsules in treatment of acute suppurative tonsillitis. Evaluation and Analysis of Dug-Use in Hospitals of China. 2017; 17:57-59. (in Chinese)"},{"key":"41","unstructured":"41. Liu Y, Shi H, Jin YH, Gao YJ, Shi YJ, Liu FZ, Guo SS, Cui XL. Experimental pharmacodynamic research <i>in vivo<\/i> of Shufengjiedu capsule on treatment and prevention of influenza. World Journal of Integrated Traditional and Western Medicine. 2010; 5:107-110. (in Chinese)"},{"key":"42","unstructured":"42. Lv WW, Zhu TN, Qiu H, Hu T, Huang SH. Pharmacodynamic study on antiviral and antibacterial effects of Shufeng Jiedu capsules <i>in vitro<\/i>. Traditional Chinese Drug Research &amp; Clinical Pharmacology. 2013; 24:234-238. (in Chinese)"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Tao Z, Gao J, Zhang G, Xue M, Yang W, Tong C, Yuan Y. Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK\/NF-kappaB pathway. Biosci Trends. 2014; 8:45-51.","DOI":"10.5582\/bst.8.45"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Ding Y, Zeng L, Li R, Chen Q, Zhou B, Chen Q, Cheng PL, Yutao W, Zheng J, Yang Z, Zhang F. The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function. BMC Complement Altern Med. 2017; 17:130.","DOI":"10.1186\/s12906-017-1585-7"},{"key":"45","unstructured":"45. Duan ZP, Jia ZH, Zhang J, Liu S, Chen Y, Liang LC, Zhang CQ, Zhang Z, Sun Y, Zhang SQ, Wang YY, Wu YL. Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: A randomized, double blind, positive controlled clinical trial. Chin Med J (Engl). 2011; 124:2925-2933."},{"key":"46","unstructured":"46. Feng GZ, Zhou F, Huang M, Yao K. Inhibitory effects of Reduning injection on human rhinoviruses <i>in vitro<\/i>. Journal of China Pharmaceutical University. 2008; 39:262-266. (in Chinese)"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Zhang X, Gu J, Cao L, Li N, Ma Y, Su Z, Ding G, Chen L, Xu X, Xiao W. Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection. Mol Biosyst. 2014; 10:2517-2525.","DOI":"10.1039\/C4MB00164H"},{"key":"48","unstructured":"48. Tang LP, He RR, Li YF, Li HB, Yao XS, Hiroshi K, Xiao W. Study on antipyretic effect of Reduning injection on lipopolysaccharide-induced fever rats. China Journal of Chinese Materia Medica. 2013; 38:2374-2377. (in Chinese)"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Liu Y, Huang Y, Wei B, Liu X, Zhang Y, Huang X, Tan Y, Sun Z. Efficacy and safety of clearing heat and detoxifying injection in the treatment of influenza: a randomized, double-blinded, placebo-controlled trial. Evid Based Complement Alternat Med. 2014; 2014:1-8.","DOI":"10.1155\/2014\/151235"},{"key":"50","unstructured":"50. Li YR, Sun SG. Revaluating the rationality and safety of Reduning injections in clinical use: An integrated approach. Chinese Journal of Clinical Pharmacology. 2015; 31:569-572. (in Chinese)"},{"key":"51","unstructured":"51. Ko R. A U.S. perspective on the adverse reactions from traditional Chinese medicines. J Chin Med Assoc. 2004; 67:109-116."},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Shaw D. Toxicological risks of Chinese herbs. Planta Med. 2010; 76:2012-2018.","DOI":"10.1055\/s-0030-1250533"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Li H, Wang S, Yue Z, Ren X, Xia J. Traditional Chinese herbal injection: Current status and future perspectives. Fitoterapia. 2018; 129:249-256.","DOI":"10.1016\/j.fitote.2018.07.009"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Qiu F, Hou XL, Takahashi K, Chen LX, Azuma J, Kang N.Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells. J Ethnopharmacol. 2012; 141:709-713.","DOI":"10.1016\/j.jep.2011.09.002"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Gu LL, Zhang XY, Xing WM, Xu JD, Lu H. Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response. Environ Toxicol Pharmacol. 2016; 45:257-264.","DOI":"10.1016\/j.etap.2016.02.004"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Anderson GD. Pregnancy-induced changes in pharmacokinetics: A mechanistic-based approach. Clin Pharmacokinet. 2005; 44:989-1008.","DOI":"10.2165\/00003088-200544100-00001"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Pavek P, Smutny T. Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. Drug Metab Rev. 2014; 46:19-32.","DOI":"10.3109\/03602532.2013.835819"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Myllynen P, Vahakangas K. Placental transfer and metabolism: An overview of the experimental models utilizing human placental tissue. Toxicol In Vitro. 2013; 27:507-512.","DOI":"10.1016\/j.tiv.2012.08.027"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Wrobel MH, Mlynarczuk J. Chlorinated insecticides (toxaphene and endrin) affect oxytocin, testosterone, oestradiol and prostaglandin secretion from ovarian and uterine cells as well as myometrial contractions in cow <i>in vitro<\/i>. Chemosphere. 2018; 198:432-441.","DOI":"10.1016\/j.chemosphere.2018.01.143"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Cao L, Pu J, Cao QR, Chen BW, Lee BJ, Cui JH. Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. Fitoterapia. 2013; 86:202-207.","DOI":"10.1016\/j.fitote.2013.03.004"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Tracy TS, Venkataramanan R, Glover DD, Caritis SN, National Institute for Child H, Human Development Network of Maternal-Fetal-Medicine U. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. Am J Obstet Gynecol. 2005; 192:633-639.","DOI":"10.1016\/j.ajog.2004.08.030"},{"key":"62","unstructured":"62. Zhao J, Wen LZ, Chen SH, Ling XZ. Effects of Chinese medicine Jinyebaidu Granules on immunity and genitality of pregnant mice. Chinese Traditional Patent Medicine. 2003; 25:130-133. (in Chinese)"},{"key":"63","unstructured":"63. Zhu J, Qiu J, Zhu Y, MA XL, Wan X, Zhang T. Teratogenicity of forsythoside gelsiccation powder in SD rats. Chinese Journal of New Drugs. 2008; 17:570-573. (in Chinese)"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Wang L, Cheng L, Yuan Q, Cui X, Shang H, Zhang B, Li Y. Adverse drug reactions of Shuanghuanglian injection: A systematic review of public literatures. J Evid Based Med. 2010; 3:18-26.","DOI":"10.1111\/j.1756-5391.2010.01067.x"},{"key":"65","unstructured":"65. Wang HS, Cheng F, Shi YQ, Li ZG, Qin HD, Liu ZP. Hypotensive response in rats and toxicological mechanisms induced by shuanghuanglian, an herbal extract mixture. Drug Discov Ther. 2008; 6:339-343."},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Gao Y, Hou R, Han Y, Fei Q, Cai R, Qi Y. Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction <i>via<\/i> C5a but not IgE. Sci Rep. 2018; 8:3572-3582.","DOI":"10.1038\/s41598-018-21843-7"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Ma AT, Zhong XH, Liu ZM, Shi WY, Du J, Zhai XH, Zhang T, Meng LG. Protective effects of baicalin against bromocriptine induced abortion in mice. Am J Chin Med. 2009; 37:85-95.","DOI":"10.1142\/S0192415X09006709"},{"key":"68","unstructured":"68. Wang YH, Song J, Dong JP, Yang TT, Hao M. Effects of baicalin on mitochondria apoptotic pathway of trophoblast cells in a preeclampsia rat model. Chinese Journal of Perinatal Medicine. 2016; 12:933-939. (in Chinese)"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Teschke R, Wolff A, Frenzel C, Schulze J. Review article: Herbal hepatotoxicity--An update on traditional Chinese medicine preparations. Aliment Pharmacol Ther. 2014; 40:32-50.","DOI":"10.1111\/apt.12798"},{"key":"70","unstructured":"70. Li HJ, Song DR. Effect of shuanghuanglian freeze-dried powder on the contraction of isolated human uterine smooth muscle in pregnancy. Lishizhen Medicine and Materia Medica Research. 2017; 28:772-773. (in Chinese)"},{"key":"71","unstructured":"71. Song DR, Zhang W, Zhao LY, Guo J, Li HJ, Du WX. Evaluation of embryo toxicity of Shuanghuanglian based on human placental barrier model. Chinese Journal of Pharmacology and Toxicology. 2017; 31:649-654. (in Chinese)"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Chen JX, Xue HJ, Ye WC, Fang BH, Liu YH, Yuan SH, Yu P, Wang YQ. Activity of andrographolide and its derivatives against influenza virus <i>in vivo<\/i> and <i>in vitro<\/i>. Biol Pharm Bull. 2009; 32:1385-1391.","DOI":"10.1248\/bpb.32.1385"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Mantani N, Andoh T, Kawamata H, Terasawa K, Ochiai H. Inhibitory effect of Ephedrae herba, an oriental traditional medicine, on the growth of influenza A\/PR\/8 virus in MDCK cells. Antiviral Res. 1999; 44:193-200.","DOI":"10.1016\/S0166-3542(99)00067-4"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Hayashi K, Imanishi N, Kashiwayama Y, Kawano A, Terasawa K, Shimada Y, Ochiai H. Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A\/PR\/8 virus <i>in vitro<\/i> and <i>in vivo<\/i>. Antiviral Res. 2007; 74:1-8.","DOI":"10.1016\/j.antiviral.2007.01.003"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. J Infect Dis. 2005; 191:1719-1729.","DOI":"10.1086\/429694"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Law AH, Yang CL, Lau AS, Chan GC. Antiviral effect of forsythoside A from Forsythia suspensa (Thunb.) Vahl fruit against influenza A virus through reduction of viral M1 protein. J Ethnopharmacol. 2017; 209:236-247.","DOI":"10.1016\/j.jep.2017.07.015"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Kong WJ, Zhao YL, Shan LM, Xiao XH, Guo WY. Thermochemical studies on the quantity-antibacterial effect relationship of four organic acids from Radix Isatidis on <i>Escherichia coli<\/i> growth. Biol Pharm Bull. 2008; 31:1301-1305.","DOI":"10.1248\/bpb.31.1301"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Pan XL, Cao X, Li N, Xu YM, Wu QY, Bai J, Yin ZM, Luo L, Lan L. Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production. Inflamm Res. 2014; 63:597-608.","DOI":"10.1007\/s00011-014-0731-7"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Lu CN, Yuan ZG, Zhang XL, Yan R, Zhao YQ, Liao M, Chen JX. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-kappaB signaling pathway. Int Immunopharmacol. 2012; 14:121-126.","DOI":"10.1016\/j.intimp.2012.06.010"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Wang W, Wang J, Dong SF, Liu CH, Italiani P, Sun SH, Xu J, Boraschi D, Ma SP, Qu D. Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response. Acta Pharmacol Sin. 2010; 31:191-201.","DOI":"10.1038\/aps.2009.205"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Cheng BH, Chan JY, Chan BC, Lin HQ, Han XQ, Zhou X, Wan DC, Wang YF, Leung PC, Fung KP, Lau CB. Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata. Carbohydr Polym. 2014; 103:244-249.","DOI":"10.1016\/j.carbpol.2013.12.048"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Shang XF, Pan H, Li MX, Miao XL, Ding H. Lonicera japonica Thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol. 2011; 138:1-21.","DOI":"10.1016\/j.jep.2011.08.016"},{"key":"83","unstructured":"83. Hossain MS, Urbi Z, Sule A, Hafizur Rahman KM. Andrographis paniculata (Burm. f.) Wall. ex Nees: A review of ethnobotany, phytochemistry, and pharmacology. Scientific World Journal. 2014; 2014:1-28."},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Li-Weber M. New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009; 35:57-68.","DOI":"10.1016\/j.ctrv.2008.09.005"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Shingnaisui K, Dey T, Manna P, Kalita J. Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review. J Ethnopharmacol. 2018; 220:35-43.","DOI":"10.1016\/j.jep.2018.03.038"},{"key":"86","unstructured":"86. Al-Salihi, Bahia. Ma Huang (Ephedrae Herba): Setting the record straight. Journal of Chinese Medicine 2016;18-30."},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Peng W, Qin RX, Li XL, Zhou H. Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc.: A review. J Ethnopharmacol. 2013; 148:729-745.","DOI":"10.1016\/j.jep.2013.05.007"},{"key":"88","unstructured":"88. Xu YL, Xue YL, Zhang HH, Lv FY, Tian ZJ, Xing ZH, LiangJin W, Li XY. Clinical observation on treatment of acute upper respiratory infection of Wind-heat Syndrome with Shufeng Jiedu capsules: A randomize-controlled double-blind test. Journal of Traditional Chinese Medicine. 2015; 56:676-679. (in Chinese)"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Saxena RC, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010; 17:178-185.","DOI":"10.1016\/j.phymed.2009.12.001"},{"key":"90","unstructured":"90. Yu DC, Chen B. Clinical observation of exogenous fever cured by Zheng Chai Hu instant granules. Guide of China Medicine. 2008; 6:124-125. (in Chinese)"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/13\/2\/13_2018.01298\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T03:22:01Z","timestamp":1558149721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/13\/2\/13_2018.01298\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2018.01298","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,30]]}}}