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Dias ALN, Ara\u00fajo FF, Cristante AF, Marcon RM, Barros Filho TEP, Letaif OB. Epidemiology of cauda equina syndrome. What changed until 2015. Rev Bras Ortop. 2017; 53:107-112.","DOI":"10.1016\/j.rbo.2017.03.004"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Li X, Dou Q, Hu S, Liu J, Kong Q, Zeng J, Song Y. Treatment of cauda equina syndrome caused by lumbar disc herniation with percutaneous endoscopic lumbar discectomy. Acta Neurol Belg. 2016; 116:185-190.","DOI":"10.1007\/s13760-015-0530-0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Korse NS, Pijpers JA, van Zwet E, Elzevier HW, Vleggeert-Lankamp CLA. Cauda Equina Syndrome: presentation, outcome, and predictors with focus on micturition, defecation, and sexual dysfunction. Eur Spine J.2017; 26:894-904.","DOI":"10.1007\/s00586-017-4943-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Abe K. Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury. J Cereb Blood Flow Metab. 2000; 20:1393-1408.","DOI":"10.1097\/00004647-200010000-00001"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 2004; 101:18117-18122.","DOI":"10.1073\/pnas.0408258102"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Haus DL, L\u00f3pez-Vel\u00e1zquez L, Gold EM, Cunningham KM, Perez H, Anderson AJ, Cummings BJ. Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Exp Neurol. 2016; 281:1-16.","DOI":"10.1016\/j.expneurol.2016.04.008"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. M\u00e9ndez-Olivos EE, Mu\u00f1oz R, Larra\u00edn J. 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Levison SW, Druckman SK, Young GM, Basu A. Neural stem cells in the subventricular zone are a source of astrocytes and oligodendrocytes, but not microglia. Dev Neurosci. 2003; 25:184-196.","DOI":"10.1159\/000072267"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Induced pluripotent stem cells for neural tissue engineering. Biomaterials. 2011; 32:5023-5032.","DOI":"10.1016\/j.biomaterials.2011.03.070"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Singh RP, Cheng YH, Nelson P, Zhou FC. Retentive multipotency of adult dorsal root ganglia stem cells. Cell Transplant. 2009; 18:55-68.","DOI":"10.3727\/096368909788237177"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fu ZY, Shi JG, Liu N, Jia LS, Yuan W, Wang Y. Differentiation of neonatal dorsal root ganglion-derived neural stem cells into oligodendrocytes after intrathecal transplantation into a cauda equina lesion model. Genet Mol Res. 2013; 12:6092-6102.","DOI":"10.4238\/2013.December.2.7"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis. 2006; 21:626-632.","DOI":"10.1016\/j.nbd.2005.09.009"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Liu X, Fu Z, Wu Y, Hu X Jr, Zhu T Jr, Jin C Jr. Neuroprotective effect of hydrogen sulfide on acute cauda equina injury in rats. Spine J. 2016; 16:402-407.","DOI":"10.1016\/j.spinee.2015.10.046"},{"key":"16","unstructured":"16. Ma B, Wu H, Jia LS, Yuan W, Shi GD, Shi JG. Cauda equina syndrome: a review of clinical progress. Chin Med J (Engl). 2009; 122:1214-1222."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Pluchino S, Zanotti L, Deleidi M, Martino G. Neural stem cells and their use as therapeutic tool in neurological disorders. 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Cell Transplant. 2019; 28:157-169.","DOI":"10.1177\/0963689718811061"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Salewski RP, Mitchell RA, Li L, Shen C, Milekovskaia M, Nagy A, Fehlings MG. Transplantation of Induced Pluripotent Stem Cell-Derived Neural Stem Cells Mediate Functional Recovery Following Thoracic Spinal Cord Injury Through Remyelination of Axons. Stem Cells Transl Med. 2015; 4:743-754.","DOI":"10.5966\/sctm.2014-0236"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Upadhyay G, Shankar S, Srivastava RK. Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes. Mol Neurobiol. 2015; 52:610-625.","DOI":"10.1007\/s12035-014-8883-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nakamura M, Bregman BS. Differences in neurotrophic factor gene expression profiles between neonate and adult rat spinal cord after injury. 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