{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:04:36Z","timestamp":1772820276094,"version":"3.50.1"},"reference-count":32,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2021,2,28]]},"DOI":"10.5582\/bst.2020.03399","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T22:06:43Z","timestamp":1614031603000},"page":"50-54","source":"Crossref","is-referenced-by-count":9,"title":["Cisatracurium attenuates LPS-induced modulation of MMP3 and junctional protein expression in human microvascular endothelial cells"],"prefix":"10.5582","volume":"15","author":[{"given":"Rana W.","family":"Kadry","sequence":"first","affiliation":[{"name":"Clinical and Experimental Therapeutics, University of Georgia, and Charlie Norwood VA Medical Center, Augusta, GA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir S.","family":"Adil","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Therapeutics, University of Georgia, and Charlie Norwood VA Medical Center, Augusta, GA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Sikora","family":"Newsome","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Therapeutics, University of Georgia, and Charlie Norwood VA Medical Center, Augusta, GA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payaningal R.","family":"Somanath","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Therapeutics, University of Georgia, and Charlie Norwood VA Medical Center, Augusta, GA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019; 5:18.","DOI":"10.1038\/s41572-019-0069-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Cepkova M, Matthay MA. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006; 21:119-143.","DOI":"10.1177\/0885066606287045"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Papazian L, Aubron C, Brochard L, <i>et al<\/i>. Formal guidelines: management of acute respiratory distress syndrome. Ann Intensive Care. 2019; 9:69.","DOI":"10.1186\/s13613-019-0540-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hall JB. Point: Should paralytic agents be routinely used in severe ARDS? Yes. Chest. 2013; 144:1440-1442.","DOI":"10.1378\/chest.13-1460"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Murray MJ, DeBlock H, Erstad B, <i>et al<\/i>. Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient. Crit Care Med. 2016; 44:2079-2103.","DOI":"10.1097\/CCM.0000000000002027"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. National Heart L, Blood Institute PCTN, Moss M, <i>et al<\/i>. Early neuromuscular blockade in the acute respiratory distress syndrome. N Engl J Med. 2019; 380:1997-2008.","DOI":"10.1056\/NEJMoa1901686"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Papazian L, Forel JM, Gacouin A, <i>et al<\/i>. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010; 363:1107-1116.","DOI":"10.1056\/NEJMoa1005372"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Herrero R, Sanchez G, Lorente JA. New insights into the mechanisms of pulmonary edema in acute lung injury. Ann Transl Med. 2018; 6:32.","DOI":"10.21037\/atm.2017.12.18"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. J Immunol. 2015; 194:855-860.","DOI":"10.4049\/jimmunol.1402513"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV. Akt1 regulates pathological angiogenesis, vascular maturation and permeability <i>in vivo<\/i>. Nat Med. 2005; 11:1188-1196.","DOI":"10.1038\/nm1307"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Gao F, Sabbineni H, Artham S, Somanath PR. Modulation of long-term endothelial-barrier integrity is conditional to the cross-talk between Akt and Src signaling. J Cell Physiol. 2017; 232:2599-2609.","DOI":"10.1002\/jcp.25791"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Alwhaibi A, Verma A, Adil MS, Somanath PR. The unconventional role of Akt1 in the advanced cancers and in diabetes-promoted carcinogenesis. Pharmacol Res. 2019; 145:104270.","DOI":"10.1016\/j.phrs.2019.104270"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Adil MS, Narayanan SP, Somanath PR. Cell-cell junctions: structure and regulation in physiology and pathology. Tissue Barriers. 2020;1848212.","DOI":"10.1080\/21688370.2020.1848212"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Gao F, Artham S, Sabbineni H, Al-Azayzih A, Peng XD, Hay N, Adams RH, Byzova TV, Somanath PR. Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover. Cell Mol Life Sci. 2016; 73:3917-3933.","DOI":"10.1007\/s00018-016-2232-z"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Artham S, Gao F, Verma A, Alwhaibi A, Sabbineni H, Hafez S, Ergul A, Somanath PR. Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury. Pharmacol Res. 2019; 141:249-263.","DOI":"10.1016\/j.phrs.2019.01.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Sabbineni H, Verma A, Artham S, Anderson D, Amaka O, Liu F, Narayanan SP, Somanath PR. Pharmacological inhibition of beta-catenin prevents EndMT <i>in vitro<\/i> and vascular remodeling <i>in vivo<\/i> resulting from endothelial Akt1 suppression. Biochem Pharmacol. 2019; 164:205-215.","DOI":"10.1016\/j.bcp.2019.04.016"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 2006; 69:562-573.","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Artham S, Verma A, Newsome AS, Somanath PR. Patients with acute respiratory distress syndrome exhibit increased stromelysin1 activity in the blood samples. Cytokine. 2020; 131:155086.","DOI":"10.1016\/j.cyto.2020.155086"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Fanelli V, Morita Y, Cappello P, Ghazarian M, Sugumar B, Delsedime L, Batt J, Ranieri VM, Zhang H, Slutsky AS. Neuromuscular blocking agent cisatracurium attenuates lung injury by inhibition of nicotinic acetylcholine receptor-alpha1. Anesthesiology. 2016; 124:132-140.","DOI":"10.1097\/ALN.0000000000000907"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Abdalla M, Sabbineni H, Prakash R, Ergul A, Fagan SC, Somanath PR. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFbeta-induced pulmonary fibrosis. Br J Pharmacol. 2015; 172:4173-4188.","DOI":"10.1111\/bph.13203"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sabbineni H, Verma A, Somanath PR. Isoform-specific effects of transforming growth factor beta on endothelial-to-mesenchymal transition. J Cell Physiol. 2018; 233:8418-8428.","DOI":"10.1002\/jcp.26801"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Goc A, Al-Azayzih A, Abdalla M, Al-Husein B, Kavuri S, Lee J, Moses K, Somanath PR. P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion <i>via<\/i> inhibition of transforming growth factor beta expression and enhanced matrix metalloproteinase 9 secretion. J Biol Chem. 2013; 288:3025-3035.","DOI":"10.1074\/jbc.M112.424770"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Gao F, Al-Azayzih A, Somanath PR. Discrete functions of GSK3alpha and GSK3beta isoforms in prostate tumor growth and micrometastasis. Oncotarget. 2015; 6:5947-5962.","DOI":"10.18632\/oncotarget.3335"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Dejana E, Orsenigo F, Lampugnani MG. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci. 2008; 121:2115-2122.","DOI":"10.1242\/jcs.017897"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Forel JM, Roch A, Marin V, Michelet P, Demory D, Blache JL, Perrin G, Gainnier M, Bongrand P, Papazian L. Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2006; 34:2749-2757.","DOI":"10.1097\/01.CCM.0000239435.87433.0D"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gainnier M, Roch A, Forel JM, Thirion X, Arnal JM, Donati S, Papazian L. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2004; 32:113-119.","DOI":"10.1097\/01.CCM.0000104114.72614.BC"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Paton WD. Mode of action of neuromuscular blocking agents. Br J Anaesth. 1956; 28:470-480.","DOI":"10.1093\/bja\/28.10.470"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. McKeown S, Richter AG, O&apos;Kane C, McAuley DF, Thickett DR. MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur Respir J. 2009; 33:77-84.","DOI":"10.1183\/09031936.00060708"},{"key":"29","unstructured":"29. Ito JT, Lourenco JD, Righetti RF, Tiberio I, Prado CM, Lopes F. Extracellular matrix component remodeling in respiratory diseases: What has been found in clinical and experimental studies? Cells. 2019; 8:342."},{"key":"30","unstructured":"30. Vandenbroucke RE, Dejonckheere E, Libert C. A therapeutic role for matrix metalloproteinase inhibitors in lung diseases? Eur Respir J. 2011; 38:1200-1214."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Schlingmann B, Molina SA, Koval M. Claudins: Gatekeepers of lung epithelial function. Semin Cell Dev Biol. 2015; 42:47-57.","DOI":"10.1016\/j.semcdb.2015.04.009"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yabasin IB, Sanches JGP, Ibrahim MM, Huidan J, Williams W, Lu ZL, Wen Q. Cisatracurium retards cell migration and invasion upon upregulation of p53 and inhibits the aggressiveness of colorectal cancer. Front Physiol. 2018; 9:941.","DOI":"10.3389\/fphys.2018.00941"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/15\/1\/15_2020.03399\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T03:44:40Z","timestamp":1616211880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/15\/1\/15_2020.03399\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,28]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2020.03399","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,28]]}}}