{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:44:05Z","timestamp":1783691045040,"version":"3.55.0"},"reference-count":35,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2025,4,30]]},"DOI":"10.5582\/bst.2024.01387","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T22:14:10Z","timestamp":1741040050000},"page":"211-220","source":"Crossref","is-referenced-by-count":3,"title":["Risk stratification model for predicting distant metastasis after hepatectomy for hepatocellular carcinoma: A multi-institutional analysis"],"prefix":"10.5582","volume":"19","author":[{"given":"Ming-Da","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Dong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Kang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Graduate, Bengbu Medical College, Bengbu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Graduate, Bengbu Medical College, Bengbu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Min","family":"Gu","sequence":"additional","affiliation":[{"name":"The First Department of General Surgery, the Fourth Hospital of Harbin, Heilongjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Liuyang People&apos;s Hospital, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ze","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Centre, First Hospital of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Yi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital, Fujian Medical University, Fujian, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Pu&apos;er People&apos;s Hospital, Yunnan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital, Shandong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Fuyang People&apos;s Hospital, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ziyang First People&apos;s Hospital, Sichuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Harbin Medical University, Heilongjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Qing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hui","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Eastern Hepatobiliary Clinical Research Institute, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."},{"name":"Department of Graduate, Bengbu Medical College, Bengbu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet. 2022; 400:1345-1362.","DOI":"10.1016\/S0140-6736(22)01200-4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Wang MD, Diao YK, Yao LQ, Fan ZQ, Wang KC, Wu H, Gu LH, Xu JH, Li C, Lv GY, Yang T. Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma.<i> iLIVER. <\/i>2024; 3:100083.","DOI":"10.1016\/j.iliver.2024.100083"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: Trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019; 16:589-604.","DOI":"10.1038\/s41575-019-0186-y"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, Roberts LR, Heimbach JK. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018; 68:723-750.","DOI":"10.1002\/hep.29913"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Yao LQ, Chen ZL, Feng ZH, <i>et al.<\/i> Clinical features of recurrence after hepatic resection for early-stage hepatocellular carcinoma and long-term survival outcomes of patients with recurrence: A multi-institutional analysis. Ann Surg Oncol. 2022; 29:4291-4303.","DOI":"10.1245\/s10434-022-11454-y"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Yan WT, Li C, Yao LQ,<i> et al. <\/i>Predictors and long-term prognosis of early and late recurrence for patients undergoing hepatic resection of hepatocellular carcinoma: A large-scale multicenter study. Hepatobiliary Surg Nutr. 2023; 12:155-168.","DOI":"10.21037\/hbsn-21-288"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wang MD, Li C, Liang L, Xing H, Sun LY, Quan B, Wu H, Xu XF, Wu MC, Pawlik TM, Lau WY, Shen F, Yang T. Early and late recurrence of hepatitis B virus-associated hepatocellular carcinoma. Oncologist. 2020; 25:e1541-e1551.","DOI":"10.1634\/theoncologist.2019-0944"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chen WY, Li C, Liu ZP, <i>et al. <\/i>Novel online calculator to predict reduced risk of early recurrence from adjuvant transarterial chemoembolisation for patients with hepatocellular carcinoma. eGastroenterology. 2023; 1:e100008.","DOI":"10.1136\/egastro-2023-100008"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Xu X, Wang MD, Xu JH, <i>et al.<\/i> Adjuvant immunotherapy improves recurrence-free and overall survival following surgical resection for intermediate\/advanced hepatocellular carcinoma a multicenter propensity matching analysis. Front Immunol. 2023; 14:1322233.","DOI":"10.3389\/fimmu.2023.1322233"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gou XX, Shi HY, Li C, Chen ZL, Ouyang W, Sun LY, Diao YK, Wang MD, Yao LQ, Gu LH, Pawlik TM, Lau WY, Shen F, Xue J, Yang T. Association of adjuvant radiation therapy with long-term overall and recurrence-free survival after hepatectomy for hepatocellular carcinoma: A multicenter propensity-matched study. Int J Radiat Oncol Biol Phys. 2022; 114:238-249.","DOI":"10.1016\/j.ijrobp.2022.05.020"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Tabrizian P, Jibara G, Shrager B, Schwartz M, Roayaie S. Recurrence of hepatocellular cancer after resection: patterns, treatments, and prognosis. Ann Surg. 2015; 261:947-955.","DOI":"10.1097\/SLA.0000000000000710"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Tsilimigras DI, Bagante F, Moris D, <i>et al.<\/i> Recurrence patterns and outcomes after resection of hepatocellular carcinoma within and beyond the Barcelona Clinic Liver Cancer Criteria. Ann Surg Oncol. 2020; 27:2321-2331.","DOI":"10.1245\/s10434-020-08452-3"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ivanics T, Murillo Perez CF, Claasen M, Claasen MPAW, Patel MS, Morgenshtern G, Erdman L, Shwaartz C, Rajendran L, O&apos;Kane GM, Hansen BE, Cleary SP, Sapisochin G. Dynamic risk profiling of HCC recurrence after curative intent liver resection. Hepatology. 2022; 76:1291-1301.","DOI":"10.1002\/hep.32411"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Papaconstantinou D, Tsilimigras DI, Pawlik TM. Recurrent hepatocellular carcinoma: Patterns, detection, staging and treatment. J Hepatocell Carcinoma. 2022; 9:947-957.","DOI":"10.2147\/JHC.S342266"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yoon JH, Choi SK, Cho SB, Kim HJ, Ko YS, Jun CH. Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection: A 15-year observational study. World J Gastroenterol. 2022; 28:5351-5363.","DOI":"10.3748\/wjg.v28.i36.5351"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hong SK, Jin XL, Suh S, Hong SY, Hong K, Han ES, Lee JM, Choi Y, Yi NJ, Lee KW, Suh KS. Different risk factors for early and late recurrence after curative resection of hepatocellular carcinoma. World J Surg. 2022; 46:197-206.","DOI":"10.1007\/s00268-021-06308-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Xu XF, Xing H, Han J, Li ZL, Lau WY, Zhou YH, Gu WM, Wang H, Chen TH, Zeng YY, Li C, Wu MC, Shen F, Yang T. Risk factors, patterns, and outcomes of late recurrence after liver resection for hepatocellular carcinoma: A multicenter study from China. JAMA Surg. 2019; 154:209-217.","DOI":"10.1001\/jamasurg.2018.4334"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Xing H, Zhang WG, Cescon M, <i>et al.<\/i> Defining and predicting early recurrence after liver resection of hepatocellular carcinoma: A multi-institutional study. HPB (Oxford). 2020; 22:677-689.","DOI":"10.1016\/j.hpb.2019.09.006"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tang SC, Diao YK, Lin KY,<i> et al.<\/i> Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: A multicenter propensity score and competing-risks regression analysis. Hepatobiliary Surg Nutr. 2024; 13:412-424.","DOI":"10.21037\/hbsn-23-7"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Feng ZH, Wang MD, Chen Z, <i>et al. <\/i>Risk factors and long-term prognosis of beyond-Milan recurrence after hepatectomy for BCLC stage 0\/A hepatocellular carcinoma: A large-scale multicenter study. Surgery. 2022; 172:1147-1155.","DOI":"10.1016\/j.surg.2022.05.023"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhang H, Han J, Xing H, Li ZL, Schwartz ME, Zhou YH, Chen TH, Wang H, Gu WM, Lau WY, Wu H, Wu MC, Shen F, Yang T. Sex difference in recurrence and survival after liver resection for hepatocellular carcinoma: A multicenter study. Surgery. 2019; 165:516-524.","DOI":"10.1016\/j.surg.2018.08.031"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wang MD, Sun LY, Qian GJ, Li C, Gu LH, Yao LQ, Diao YK, Pawlik TM, Lau WY, Huang DS, Shen F, Yang T. Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: A retrospective cohort study. Int J Surg. 2022; 105:106843.","DOI":"10.1016\/j.ijsu.2022.106843"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Liang L, Quan B, Wu H, <i>et al. <\/i>Development and validation of an individualized prediction calculator of postoperative mortality within 6 months after surgical resection for hepatocellular carcinoma: an international multicenter study. Hepatol Int. 2021; 15:459-471.","DOI":"10.1007\/s12072-021-10140-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ni X, Li D, Dai S, Pan H, Sun H, Ao J, Chen L, Kong H. Development and evaluation of nomograms to predict the cancer-specific mortality and overall mortality of patients with hepatocellular carcinoma. Biomed Res Int. 2021; 2021:1658403.","DOI":"10.1155\/2021\/1658403"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Lu Y, Ren S, Jiang J. Development and validation of a nomogram for survival prediction in hepatocellular carcinoma after partial hepatectomy. BMC Surg. 2023; 23:27.","DOI":"10.1186\/s12893-023-01922-x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Diao YK, Sun L, Wang MD,<i> et al.<\/i> Development and validation of nomograms to predict survival and recurrence after hepatectomy for intermediate\/advanced (BCLC stage B\/C) hepatocellular carcinoma. Surgery. 2024; 176:137-147.","DOI":"10.1016\/j.surg.2024.03.028"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Yoh T, Seo S, Taura K, Iguchi K, Ogiso S, Fukumitsu K, Ishii T, Kaido T, Uemoto S. Surgery for recurrent hepatocellular carcinoma: Achieving long-term survival.<i> Ann Surg. <\/i>2021; 273:792-799.","DOI":"10.1097\/SLA.0000000000003358"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Midorikawa Y, Takayama T, Nakayama H, Moriguchi M, Aramaki O, Yamazaki S, Teramoto K, Yoshida N, Kobayashi N, Tsuji S, Higaki T. Favorable outcomes of surgical resection for extrahepatic recurrent hepatocellular carcinoma. Hepatol Res. 2020; 50:978-984.","DOI":"10.1111\/hepr.13526"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Mo A, Lin B, Chen D. Efficacy of sequential TACE on primary hepatocellular carcinoma with microvascular invasion after radical resection: a systematic review and meta-analysis. World J Surg Oncol. 2023; 21:277.","DOI":"10.1186\/s12957-023-03160-0"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Feng X, Feng GY, Tao J, Ao YP, Wu XH, Qi SG, Shi ZR. Comparison of different adjuvant therapy regimen efficacies in patients with high risk of recurrence after radical resection of hepatocellular carcinoma. J Cancer Res Clin Oncol. 2023; 149:10505-10518.","DOI":"10.1007\/s00432-023-04874-0"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Strasberg SM, Phillips C. Use and dissemination of the brisbane 2000 nomenclature of liver anatomy and resections. Ann Surg. 2013; 257:377-382.","DOI":"10.1097\/SLA.0b013e31825a01f6"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Lu M, Zhu WW, Wang X,<i> et al. <\/i>ACOT12-dependent alteration of acetyl-CoA drives hepatocellular carcinoma metastasis by epigenetic induction of epithelial-mesenchymal transition. Cell Metab. 2019; 29:886-900. e5.","DOI":"10.1016\/j.cmet.2018.12.019"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Sun YF, Xu Y, Yang XR, Guo W, Zhang X, Qiu SJ, Shi RY, Hu B, Zhou J, Fan J. Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection. Hepatology. 2013; 57:1458-1468.","DOI":"10.1002\/hep.26151"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Hu ZQ, Zhou SL, Li J, Zhou ZJ, Wang PC, Xin HY, Mao L, Luo CB, Yu SY, Huang XW, Cao Y, Fan J, Zhou J. Circular RNA sequencing identifies CircASAP1 as a key regulator in hepatocellular carcinoma metastasis. Hepatology. 2020; 72:906-922.","DOI":"10.1002\/hep.31068"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Guo W, Sun YF, Shen MN, <i>et al. <\/i>Circulating tumor cells with stem-like phenotypes for diagnosis, prognosis, and therapeutic response evaluation in hepatocellular carcinoma. Clin Cancer Res. 2018; 24:2203-2213.","DOI":"10.1158\/1078-0432.CCR-17-1753"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/19\/2\/19_2024.01387\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:40:54Z","timestamp":1746852054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/19\/2\/19_2024.01387\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2024.01387","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"article-number":"2024.01387"}}