{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:34:01Z","timestamp":1787315641303,"version":"build-2736575974"},"reference-count":50,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2025,6,30]]},"DOI":"10.5582\/bst.2025.01067","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T18:06:41Z","timestamp":1745258801000},"page":"351-360","source":"Crossref","is-referenced-by-count":5,"title":["Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma"],"prefix":"10.5582","volume":"19","author":[{"given":"Xuedong","family":"Wang","sequence":"first","affiliation":[{"name":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjun","family":"Tang","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"The 2nd Department of General Surgery, The Second People&apos;s Hospital of Changzhi, Changzhi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Nantong University, Nantong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Liuyang People&apos;s Hospital, Liuyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Pu&apos;er People&apos;s Hospital, Pu&apos;er, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingda","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ohio State University, Wexner Medical Center, Columbus, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing University, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yang","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China."},{"name":"Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68:394-424.","DOI":"10.3322\/caac.21492"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Wang MD, Diao YK, Yao LQ, Fan ZQ, Wang KC, Wu H, Gu HL, Xu JH, Li C, Lv GY, Yang T. Emerging role of molecular diagnosis and personalized therapy for hepatocellular carcinoma. iLIVER. 2024; 3:100083.","DOI":"10.1016\/j.iliver.2024.100083"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet. 2022; 400:1345-1362.","DOI":"10.1016\/S0140-6736(22)01200-4"},{"key":"4","unstructured":"4. Vitale A, Cabibbo G, Iavarone M<i>, et al.<\/i> Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept. Lancet Oncol. 2023; 24:e312-e322."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Pinna AD, Yang T, Mazzaferro V, De Carlis L, Zhou J, Roayaie S, Shen F, Sposito C, Cescon M, Di Sandro S, Yi-Feng H, Johnson P, Cucchetti A. Liver Transplantation and Hepatic Resection can Achieve Cure for Hepatocellular Carcinoma. Ann Surg. 2018; 268:868-875.","DOI":"10.1097\/SLA.0000000000002889"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Yao LQ, Chen ZL, Feng ZH, <i>et al.<\/i> Clinical Features of Recurrence After Hepatic Resection for Early-Stage Hepatocellular Carcinoma and Long-Term Survival Outcomes of Patients with Recurrence: A Multi-institutional Analysis. Ann Surg Oncol. 2022; 29:4291-4303.","DOI":"10.1245\/s10434-022-11454-y"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yao LQ, Li C, Diao YK, <i>et al.<\/i> Grading severity of microscopic vascular invasion was independently associated with recurrence and survival following hepatectomy for solitary hepatocellular carcinoma. Hepatobiliary Surg Nutr. 2024; 13:16-28.","DOI":"10.21037\/hbsn-22-411"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Diao YK, Sun L, Wang MD, <i>et al.<\/i> Development and validation of nomograms to predict survival and recurrence after hepatectomy for intermediate\/advanced (BCLC stage B\/C) hepatocellular carcinoma. Surgery. 2024; 176:137-147.","DOI":"10.1016\/j.surg.2024.03.028"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tang SC, Diao YK, Lin KY, <i>et al.<\/i> Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis. Hepatobiliary Surg Nutr. 2024; 13:412-424.","DOI":"10.21037\/hbsn-23-7"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yan WT, Li C, Yao LQ, <i>et al.<\/i> Predictors and long-term prognosis of early and late recurrence for patients undergoing hepatic resection of hepatocellular carcinoma: a large-scale multicenter study. Hepatobiliary Surg Nutr. 2023; 12:155-168.","DOI":"10.21037\/hbsn-21-288"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Chen WY, Li C, Liu ZP, <i>et al.<\/i> Novel online calculator to predict reduced risk of early recurrence from adjuvant transarterial chemoembolisation for patients with hepatocellular carcinoma. eGastroenterology. 2023; 1:e100008.","DOI":"10.1136\/egastro-2023-100008"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kurokawa T, Ohkohchi N. Platelets in liver disease, cancer and regeneration. World J Gastroenterol. 2017; 23:3228-3239.","DOI":"10.3748\/wjg.v23.i18.3228"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Carr BI, Guerra V. Thrombocytosis and hepatocellular carcinoma. Dig Dis Sci. 2013; 58:1790-1796.","DOI":"10.1007\/s10620-012-2527-3"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Gay LJ, Felding-Habermann B. Contribution of platelets to tumour metastasis. Nat Rev Cancer. 2011; 11:123-134.","DOI":"10.1038\/nrc3004"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Zhao J, Huang A, Zeller J, Peter K, McFadyen JD. Decoding the role of platelets in tumour metastasis: enigmatic accomplices and intricate targets for anticancer treatments. Front Immunol. 2023; 14:1256129.","DOI":"10.3389\/fimmu.2023.1256129"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Pavlovic N, Rani B, Gerwins P, Heindryckx F. Platelets as Key Factors in Hepatocellular Carcinoma. Cancers (Basel). 2019; 11:1022.","DOI":"10.3390\/cancers11071022"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Mammadova-Bach E, Mangin P, Lanza F, Gachet C. Platelets in cancer. From basic research to therapeutic implications. Hamostaseologie. 2015; 35:325-336.","DOI":"10.5482\/hamo-14-11-0065"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Maan R, de Knegt RJ, Veldt BJ. Management of Thrombocytopenia in Chronic Liver Disease: Focus on Pharmacotherapeutic Strategies. Drugs. 2015; 75:1981-1992.","DOI":"10.1007\/s40265-015-0480-0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Gallo P, Terracciani F, Di Pasquale G, Esposito M, Picardi A, Vespasiani-Gentilucci U. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures. World J Gastroenterol. 2022; 28:4061-4074.","DOI":"10.3748\/wjg.v28.i30.4061"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Peck-Radosavljevic M. Thrombocytopenia in chronic liver disease. Liver Int. 2017; 37:778-793.","DOI":"10.1111\/liv.13317"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Stone RL, Nick AM, McNeish IA, <i>et al.<\/i> Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012; 366:610-618.","DOI":"10.1056\/NEJMc1203095"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Hwang SJ, Luo JC, Li CP, Chu CW, Wu JC, Lai CR, Chiang JH, Chau GY, Lui WY, Lee CC, Chang FY, Lee SD. Thrombocytosis: a paraneoplastic syndrome in patients with hepatocellular carcinoma. World J Gastroenterol. 2004; 10:2472-2477.","DOI":"10.3748\/wjg.v10.i17.2472"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kaneko K, Shirai Y, Wakai T, Yokoyama N, Akazawa K, Hatakeyama K. Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma. World J Gastroenterol. 2005; 11:5888-5892.","DOI":"10.3748\/wjg.v11.i37.5888"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Amano H, Tashiro H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Itamoto T, Asahara T, Ohdan H. Significance of platelet count in the outcomes of hepatectomized patients with hepatocellular carcinoma exceeding the Milan criteria. J Gastrointest Surg. 2011; 15:1173-1181.","DOI":"10.1007\/s11605-011-1538-2"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol. 2008; 48 Suppl 1:S20-37.","DOI":"10.1016\/j.jhep.2008.01.022"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Maithel SK, Kneuertz PJ, Kooby DA, Scoggins CR, Weber SM, Martin RC 2nd, McMasters KM, Cho CS, Winslow ER, Wood WC, Staley CA 3rd. Importance of low preoperative platelet count in selecting patients for resection of hepatocellular carcinoma: a multi-institutional analysis. J Am Coll Surg. 2011; 212:638-648; discussion 648-650.","DOI":"10.1016\/j.jamcollsurg.2011.01.004"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Pang Q, Qu K, Zhang JY, Song SD, Liu SS, Tai MH, Liu HC, Liu C. The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2015; 94:e1431.","DOI":"10.1097\/MD.0000000000001431"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA. Platelet-derived serotonin mediates liver regeneration. Science. 2006; 312:104-107.","DOI":"10.1126\/science.1123842"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Lee CH, Lin YJ, Lin CC, Yen CL, Shen CH, Chang CJ, Hsieh SY. Pretreatment platelet count early predicts extrahepatic metastasis of human hepatoma. Liver Int. 2015; 35:2327-2336.","DOI":"10.1111\/liv.12817"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Scheiner B, Kirstein M, Popp S, Hucke F, Bota S, Rohr-Udilova N, Reiberger T, M\u00fcller C, Trauner M, Peck-Radosavljevic M, Vogel A, Sieghart W, Pinter M. Association of Platelet Count and Mean Platelet Volume with Overall Survival in Patients with Cirrhosis and Unresectable Hepatocellular Carcinoma. Liver Cancer. 2019; 8:203-217.","DOI":"10.1159\/000489833"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Shen SL, Fu SJ, Chen B, Kuang M, Li SQ, Hua YP, Liang LJ, Guo P, Hao Y, Peng BG. Preoperative Aspartate Aminotransferase to Platelet Ratio is an Independent Prognostic Factor for Hepatitis B-Induced Hepatocellular Carcinoma After Hepatic Resection. Ann Surg Oncol. 2014;21:3802-3809.","DOI":"10.1245\/s10434-014-3771-x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Pang Q, Zhang JY, Xu XS, Song SD, Qu K, Chen W, Zhou YY, Miao RC, Liu SS, Dong YF, Liu C. Significance of platelet count and platelet-based models for hepatocellular carcinoma recurrence. World J Gastroenterol. 2015; 21:5607-5621.","DOI":"10.3748\/wjg.v21.i18.5607"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Shim JH, Jun MJ, Han S, Lee YJ, Lee SG, Kim KM, Lim YS, Lee HC. Prognostic nomograms for prediction of recurrence and survival after curative liver resection for hepatocellular carcinoma. Ann Surg. 2015; 261:939-946.","DOI":"10.1097\/SLA.0000000000000747"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Pawlik TM, Delman KA, Vauthey JN, Nagorney DM, Ng IO, Ikai I, Yamaoka Y, Belghiti J, Lauwers GY, Poon RT, Abdalla EK. Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl. 2005; 11:1086-1092.","DOI":"10.1002\/lt.20472"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Kuter DJ. Milestones in understanding platelet production: a historical overview. Br J Haematol. 2014; 165:248-258.","DOI":"10.1111\/bjh.12781"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Nilles KM, Flamm SL. Thrombocytopenia in Chronic Liver Disease: New Management Strategies. Clin Liver Dis. 2020; 24:437-451.","DOI":"10.1016\/j.cld.2020.04.009"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Strasberg SM. Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg. 2005; 12:351-355.","DOI":"10.1007\/s00534-005-0999-7"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. D&apos;Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006; 44:217-231.","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Lesurtel M, Clavien PA. Platelet-derived serotonin: translational implications for liver regeneration. Hepatology. 2014; 60:30-33.","DOI":"10.1002\/hep.27067"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Rachidi S, Metelli A, Riesenberg B, Wu BX, Nelson MH, Wallace C, Paulos CM, Rubinstein MP, Garrett-Mayer E, Hennig M, Bearden DW, Yang Y, Liu B, Li Z. Platelets subvert T cell immunity against cancer <i>via<\/i> GARP-TGF\u03b2 axis. Sci Immunol. 2017; 2:eaai7911.","DOI":"10.1126\/sciimmunol.aai7911"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Buergy D, Wenz F, Groden C, Brockmann MA. Tumor-platelet interaction in solid tumors. Int J Cancer. 2012; 130:2747-2760.","DOI":"10.1002\/ijc.27441"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Yan M, Jurasz P. The role of platelets in the tumor microenvironment: From solid tumors to leukemia. Biochim Biophys Acta. 2016; 1863:392-400.","DOI":"10.1016\/j.bbamcr.2015.07.008"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011; 20:576-590.","DOI":"10.1016\/j.ccr.2011.09.009"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Haemmerle M, Stone RL, Menter DG, Afshar-Kharghan V, Sood AK. The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell. 2018; 33:965-983.","DOI":"10.1016\/j.ccell.2018.03.002"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Chen ZL, Yao LQ, Pu JL, <i>et al.<\/i> Impact of concurrent splenectomy and esophagogastric devascularization on surgical outcomes of partial hepatectomy for hepatocellular carcinoma in patients with clinically significant portal hypertension: A multicenter propensity score matching analysis. Eur J Surg Oncol. 2022; 48:1078-1086.","DOI":"10.1016\/j.ejso.2021.11.118"},{"key":"46","unstructured":"46. Miyoshi A, Ide T, Kitahara K, Noshiro H. Appraisal of simultaneous laparoscopic splenectomy and hepatic resection in the treatment of hepatocellular carcinoma with hypersplenic thrombocytopenia. Hepatogastroenterology. 2013; 60:1689-1692."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Terrault N, Chen YC, Izumi N, Kayali Z, Mitrut P, Tak WY, Allen LF, Hassanein T. Avatrombopag Before Procedures Reduces Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia. Gastroenterology. 2018; 155:705-718.","DOI":"10.1053\/j.gastro.2018.05.025"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A. 2012; 109:E2165-2172.","DOI":"10.1073\/pnas.1209182109"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Ricciotti E, Wangensteen KJ, FitzGerald GA. Aspirin in Hepatocellular Carcinoma. Cancer Res. 2021; 81:3751-3761.","DOI":"10.1158\/0008-5472.CAN-21-0758"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Sitia G, Iannacone M, Guidotti LG. Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. J Hepatol. 2013; 59:1135-1138.","DOI":"10.1016\/j.jhep.2013.05.040"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/19\/3\/19_2025.01067\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:32:02Z","timestamp":1751675522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/19\/3\/19_2025.01067\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2025.01067","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"article-number":"2025.01067"}}