{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:59:05Z","timestamp":1790189945389,"version":"4.1.0"},"reference-count":191,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2026,2,28]]},"DOI":"10.5582\/bst.2025.01279","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T22:06:00Z","timestamp":1763589960000},"page":"27-44","source":"Crossref","is-referenced-by-count":1,"title":["The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging"],"prefix":"10.5582","volume":"20","author":[{"given":"Lichao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China."},{"name":"Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Karako","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianwen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Partridge L, Deelen J, Slagboom PE. Facing up to the global challenges of ageing. Nature. 2018; 561:45-56.","DOI":"10.1038\/s41586-018-0457-8"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023; 186:243-278.","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Yousefzadeh MJ, Flores RR, Zhu Y, <i>et al.<\/i> An aged immune system drives senescence and ageing of solid organs. Nature. 2021; 594:100-105.","DOI":"10.1038\/s41586-021-03547-7"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Sang Y, Ning X, Xu Q, Wang L, Yan Y, Zhang L, Bi X<i>.<\/i> Characterization of transcriptomics during aging and genes required for lifespan in Drosophila intestine. Sci Rep. 2025; 15:14692.","DOI":"10.1038\/s41598-025-98888-y"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Tran L, Greenwood-Van Meerveld B. Age-associated remodeling of the intestinal epithelial barrier. J Gerontol A Biol Sci Med Sci. 2013; 68:1045-1056.","DOI":"10.1093\/gerona\/glt106"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Becker L, Nguyen L, Gill J, Kulkarni S, Pasricha PJ, Habtezion A. Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system. Gut. 2018; 67:827-836.","DOI":"10.1136\/gutjnl-2016-312940"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wang X, Luo Y, He S, <i>et al.<\/i> Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates. Nat Aging. 2024; 4:414-433.","DOI":"10.1038\/s43587-024-00572-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig Dis Basel Switz. 2007; 25:112-117.","DOI":"10.1159\/000099474"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Guo Z, Wang G, Wu B, Chou WC, Cheng L, Zhou C, Lou J, Wu D, Su L, Zheng J, Ting JP, Wan YY<i>.<\/i> DCAF1 regulates Treg senescence <i>via<\/i> the ROS axis during immunological aging. J Clin Invest. 2020; 130:5893-5908.","DOI":"10.1172\/JCI136466"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Meng G, Monaghan TM, Duggal NA, Tighe P, Peerani F<i>.<\/i> Microbial-immune crosstalk in elderly-onset inflammatory bowel disease: Unchartered territory. J Crohns Colitis. 2023; 17:1309-1325.","DOI":"10.1093\/ecco-jcc\/jjad025"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wei S, Wu X, Chen M, Xiang Z, Li X, Zhang J, Dong W<i>.<\/i> Exosomal-miR-129-2-3p derived from Fusobacterium nucleatum-infected intestinal epithelial cells promotes experimental colitis through regulating TIMELESS-mediated cellular senescence pathway. Gut Microbes. 2023; 15:2240035.","DOI":"10.1080\/19490976.2023.2240035"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Rana SV, Sharma S, Malik A, Kaur J, Prasad KK, Sinha SK, Singh<i>.<\/i> Small intestinal bacterial overgrowth and orocecal transit time in patients of inflammatory bowel disease. Dig Dis Sci. 2013; 58:2594-2598.","DOI":"10.1007\/s10620-013-2694-x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Valvano M, Capannolo A, Cesaro N, Stefanelli G, Fabiani S, Frassino S, Monaco S, Magistroni M, Viscido A, Latella G<i>.<\/i> Nutrition, nutritional status, micronutrients deficiency, and disease course of inflammatory bowel disease. Nutrients. 2023; 15:3824.","DOI":"10.3390\/nu15173824"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Rana SV, Sharma S, Kaur J, Prasad KK, Sinha SK, Kochhar R, Malik A, Morya RK<i>.<\/i> Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients. J Crohns Colitis. 2014; 8:859-865.","DOI":"10.1016\/j.crohns.2014.01.007"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Funk MC, Zhou J, Boutros M. Ageing, metabolism and the intestine. EMBO Rep. 2020; 21:e50047.","DOI":"10.15252\/embr.202050047"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Jasper H. Intestinal stem cell aging: Origins and interventions. Annu Rev Physiol. 2020; 82:203-226.","DOI":"10.1146\/annurev-physiol-021119-034359"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sienkiewicz M, Sroka K, Binienda A, Jurk D, Fichna J<i>.<\/i> A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases. Ageing Res Rev. 2023; 91:102083.","DOI":"10.1016\/j.arr.2023.102083"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Faye AS, Colombel JF. Aging and IBD: A new challenge for clinicians and researchers. Inflamm Bowel Dis. 2022; 28:126-132.","DOI":"10.1093\/ibd\/izab039"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hohman LS, Osborne LC. A gut-centric view of aging: Do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence? Aging Cell. 2022; 21:e13700.","DOI":"10.1111\/acel.13700"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Costa CM, Pedrosa SS, Kirkland JL, Reis F, Madureira AR<i>.<\/i> The senotherapeutic potential of phytochemicals for age-related intestinal disease. Ageing Res Rev. 2024; 104:102619.","DOI":"10.1016\/j.arr.2024.102619"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018; 15:505-522.","DOI":"10.1038\/s41569-018-0064-2"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Jang DH, Shin JW, Shim E, Ohtani N, Jeon OH<i>.<\/i> The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review. Aging Cell. 2024; 23:e14315.","DOI":"10.1111\/acel.14315"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Chen SY, Wang TY, Zhao C, Wang HJ<i>.<\/i> Oxidative stress bridges the gut microbiota and the occurrence of frailty syndrome. World J Gastroenterol. 2022; 28:5547-5556.","DOI":"10.3748\/wjg.v28.i38.5547"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Wu M, Luo Q, Nie R, Yang X, Tang Z, Chen H<i>.<\/i> Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota. Crit Rev Food Sci Nutr. 2021; 61:2175-2193.","DOI":"10.1080\/10408398.2020.1773390"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Shemtov SJ, Emani R, Bielska O, Covarrubias AJ, Verdin E, Andersen JK, Winer DA<i>.<\/i> The intestinal immune system and gut barrier function in obesity and ageing. FEBS J. 2023; 290:4163-4186.","DOI":"10.1111\/febs.16558"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Shi L, Jin L, Huang W. Bile acids, intestinal barrier dysfunction, and related diseases. Cells. 2023;12:1888.","DOI":"10.3390\/cells12141888"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Zou Y, Yan H, Li C, Wen F, Jize X, Zhang C, Liu S, Zhao Y, Fu Y, Li L, Liu F, Chen J, Li R, Chen X, Tian M<i>.<\/i> A pectic polysaccharide from Codonopsis pilosula alleviates inflammatory response and oxidative stress of aging mice <i>via<\/i> modulating intestinal microbiota-related gut-liver axis. Antioxid Basel Switz. 2023; 12:1781.","DOI":"10.3390\/antiox12091781"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Gurumayum N, Devi MB, Khound P, Bhattacharya A, Sarma H, Khan MR, Devi<i>.<\/i> Bioactive fraction of Musa balbisiana seed mitigates D-galactose-induced brain aging <i>via<\/i> SIRT1\/PGC-1\u03b1\/FoxO3a activation and intestinal barrier dysfunction by modulating gut microbiota and core metabolites. Free Radic Biol Med. 2025; 226:43-55.","DOI":"10.1016\/j.freeradbiomed.2024.11.016"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Singh R, Chandrashekharappa S, Bodduluri SR, <i>et al.<\/i> Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019; 10:89.","DOI":"10.1038\/s41467-018-07859-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Abankwah JK, Wang Y, Wang J, Ogbe SE, Pozzo LD, Chu X, Bian Y<i>.<\/i> Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies. Heliyon. 2024; 10:e37883.","DOI":"10.1016\/j.heliyon.2024.e37883"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. He D, Wu H, Xiang J, Ruan X, Peng P, Ruan Y, Chen YG, Wang Y, Yu Q, Zhang H, Habib SL, De Pinho RA, Liu H, Li B<i>.<\/i> Gut stem cell aging is driven by mTORC1 <i>via<\/i> a p38 MAPK-p53 pathway. Nat Commun. 2020; 11:37.","DOI":"10.1038\/s41467-019-13911-x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Chen Y, Hao Z, Zhao H, Duan X, Jia D, Li K, Yang Y, Cui H, Gao M, Zhao D<i>.<\/i> Berberine alleviates intestinal barrier dysfunction in glucolipid metabolism disorder hamsters by modulating gut microbiota and gut-microbiota-related tryptophan metabolites. J Sci Food Agric. 2023; 103:1464-1473.","DOI":"10.1002\/jsfa.12242"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Santoro A, Bientinesi E, Monti D. Immunosenescence and inflammaging in the aging process: Age-related diseases or longevity? Ageing Res Rev. 2021; 71:101422.","DOI":"10.1016\/j.arr.2021.101422"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Agrawal S, Gupta S. TLR1\/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol. 2011; 31:89-98.","DOI":"10.1007\/s10875-010-9456-8"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Bashir H, Singh S, Singh RP, Agrewala JN, Kumar R<i>.<\/i> Age-mediated gut microbiota dysbiosis promotes the loss of dendritic cells tolerance. Aging Cell. 2023; 22:e13838.","DOI":"10.1111\/acel.13838"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Delfini M, Stakenborg N, Viola MF, Boeckxstaens G<i>.<\/i> Macrophages in the gut: Masters in multitasking. Immunity. 2022; 55:1530-1548.","DOI":"10.1016\/j.immuni.2022.08.005"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Becker L, Spear ET, Sinha SR, Haileselassie Y, Habtezion A<i>.<\/i> Age-related changes in gut microbiota alter phenotype of muscularis macrophages and disrupt gastrointestinal motility. Cell Mol Gastroenterol Hepatol. 2019; 7:243-245. e2.","DOI":"10.1016\/j.jcmgh.2018.09.001"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Zhang Z, Schaefer C, Jiang W, Lu Z, Lee J, Sziraki A, Abdulraouf A, Wick B, Haeussler M, Li Z, Molla G, Satija R, Zhou W, Cao J<i>.<\/i> A panoramic view of cell population dynamics in mammalian aging. Science. 2024; eadn3949.","DOI":"10.1101\/2024.03.01.583001"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Gao H, Nepovimova E, Adam V, Heger Z, Valko M, Wu Q, Kuca K<i>.<\/i> Age-associated changes in innate and adaptive immunity: Role of the gut microbiota. Front Immunol. 2024; 15:1421062.","DOI":"10.3389\/fimmu.2024.1421062"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. M\u00f8ller SH, Hsueh PC, Yu YR, Zhang L, Ho PC<i>.<\/i> Metabolic programs tailor T cell immunity in viral infection, cancer, and aging. Cell Metab. 2022; 34:378-395.","DOI":"10.1016\/j.cmet.2022.02.003"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Carrasco E, G\u00f3mez de Las Heras MM, Gaband\u00e9-Rodr\u00edguez E, Desd\u00edn-Mic\u00f3 G, Aranda JF, Mittelbrunn M<i>.<\/i> The role of T cells in age-related diseases. Nat Rev Immunol. 2022; 22:97-111.","DOI":"10.1038\/s41577-021-00557-4"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Branca JJV, Gulisano M, Nicoletti C. Intestinal epithelial barrier functions in ageing. Ageing Res Rev. 2019; 54:100938.","DOI":"10.1016\/j.arr.2019.100938"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Kociszewska D, Vlajkovic S. Age-related hearing loss: The link between inflammaging, immunosenescence, and gut dysbiosis. Int J Mol Sci. 2022; 23:7348.","DOI":"10.3390\/ijms23137348"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Chen Y, Li X, Yang M, <i>et al.<\/i> Time-restricted eating reveals a &apos;younger&apos; immune system and reshapes the intestinal microbiome in human. Redox Biol. 2024; 78:103422.","DOI":"10.1016\/j.redox.2024.103422"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Ghosh TS, Rampelli S, Jeffery IB, <i>et al.<\/i> Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: The NU-AGE 1-year dietary intervention across five European countries. Gut. 2020; 69:1218-1228.","DOI":"10.1136\/gutjnl-2019-319654"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Di Giosia P, Stamerra CA, Giorgini P, Jamialahamdi T, Butler AE, Sahebkar A<i>.<\/i> The role of nutrition in inflammaging. Ageing Res Rev. 2022; 77:101596.","DOI":"10.1016\/j.arr.2022.101596"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A<i>.<\/i> Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014; 13:3-10.","DOI":"10.1016\/j.autrev.2013.06.004"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Zhang K, Guo J, Yan W, Xu L<i>.<\/i> Macrophage polarization in inflammatory bowel disease. Cell Commun Signal CCS. 2023; 21:367.","DOI":"10.1186\/s12964-023-01386-9"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Zhuang H, Lv Q, Zhong C, Cui Y, He L, Zhang C, Yu J<i>.<\/i> Tiliroside ameliorates ulcerative colitis by restoring the M1\/M2 macrophage balance <i>via<\/i> the HIF-1\u03b1\/glycolysis pathway. Front Immunol. 2021; 12:649463.","DOI":"10.3389\/fimmu.2021.649463"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Liu L, Davidorf B, Dong P, Peng A, Song Q, He Z<i>.<\/i> Decoding the mosaic of inflammatory bowel disease: Illuminating insights with single-cell RNA technology. Comput Struct Biotechnol J. 2024; 23:2911-23.","DOI":"10.1016\/j.csbj.2024.07.011"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Zhang Y, Chen J, Fu H, Kuang S, He F, Zhang M, Shen Z, Qin W, Lin Z, Huang S<i>.<\/i> Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell\/Treg balance in inflamed periodontium. Int J Oral Sci. 2021; 13:43.","DOI":"10.1038\/s41368-021-00150-4"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Jia L, Jiang Y, Wu L, Fu J, Du J, Luo Z, Guo L, Xu J, Liu Y<i>.<\/i> Porphyromonas gingivalis aggravates colitis <i>via<\/i> a gut microbiota-linoleic acid metabolism-Th17\/Treg cell balance axis. Nat Commun. 2024; 15:1617.","DOI":"10.1038\/s41467-024-45473-y"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Joseph AM, Ahmed A, Goc J, Horn V, Fiedler B, Garone D, Grigg JB, Uddin J, Teng F, Fritsch M, Vivier E, Sonnenberg GF<i>.<\/i> RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut. Mucosal Immunol. 2024; 17:1212-1221.","DOI":"10.1016\/j.mucimm.2024.08.004"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Kokkinou E, Soini T, Pandey RV, <i>et al.<\/i> The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis. Cell Rep Med. 2023; 4:101038.","DOI":"10.1016\/j.xcrm.2023.101038"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Ahmed A, Joseph AM, Zhou J, Horn V, Uddin J, Lyu M, Goc J; JRI Live Cell Bank; Sockolow RE, Wing JB, Vivier E, Sakaguchi S, Sonnenberg GF<i>.<\/i> CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. Nature. 2024; 630:976-983.","DOI":"10.1038\/s41586-024-07537-3"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Saez A, Herrero-Fernandez B, Gomez-Bris R, S\u00e1nchez-Martinez H, Gonzalez-Granado JM<i>.<\/i> Pathophysiology of inflammatory bowel disease: Innate immune system. Int J Mol Sci. 2023; 24:1526.","DOI":"10.3390\/ijms24021526"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Calder PC, Ortega EF, Meydani SN, Adkins Y, Stephensen CB, Thompson B, Zwickey H<i>.<\/i> Nutrition, immunosenescence, and infectious disease: An overview of the scientific evidence on micronutrients and on modulation of the gut microbiota. Adv Nutr Bethesda Md. 2022; 13:S1-S26.","DOI":"10.1093\/advances\/nmac052"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Guan L, Crasta KC, Maier AB. Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence. Ageing Res Rev. 2022; 78:101634.","DOI":"10.1016\/j.arr.2022.101634"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Sender R, Milo R. The distribution of cellular turnover in the human body. Nat Med. 2021; 27:45-48.","DOI":"10.1038\/s41591-020-01182-9"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. in P, Duan X, Li L, Zhou P, Zou CG, Xie K<i>.<\/i> Cellular senescence in cancer: Molecular mechanisms and therapeutic targets. MedComm. 2024; 5:e542.","DOI":"10.1002\/mco2.542"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Rajendran P, Alzahrani AM, Hanieh HN, Kumar SA, Ben Ammar R, Rengarajan T, Alhoot MA<i>.<\/i> Autophagy and senescence: A new insight in selected human diseases. J Cell Physiol. 2019; 234:21485-21492.","DOI":"10.1002\/jcp.28895"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Tai H, Wang Z, Gong H, <i>et al.<\/i> Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence. Autophagy. 2017; 13:99-113.","DOI":"10.1080\/15548627.2016.1247143"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Moreno-Blas D, Gorostieta-Salas E, Castro-Obreg\u00f3n S. Connecting chaperone-mediated autophagy dysfunction to cellular senescence. Ageing Res Rev. 2018; 41:34-41.","DOI":"10.1016\/j.arr.2017.11.001"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Tan JX, Finkel T. Lysosomes in senescence and aging. EMBO Rep. 2023; 24:e57265.","DOI":"10.15252\/embr.202357265"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Park SS, Lee YK, Kim YH, Park SH, Kang HY, Kim JC, Kim DJ, Lim SB, Yoon G, Kim JH, Choi YW, Park TJ<i>.<\/i> Distribution and impact of p16INK4A+ senescent cells in elderly tissues: A focus on senescent immune cell and epithelial dysfunction. Exp Mol Med. 2024; 56:2631-41.","DOI":"10.1038\/s12276-024-01354-4"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Blander JM. On cell death in the intestinal epithelium and its impact on gut homeostasis. Curr Opin Gastroenterol. 2018; 34:413-419.","DOI":"10.1097\/MOG.0000000000000481"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Wahida A, M\u00fcller M, Hiergeist A, <i>et al.<\/i> XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells. Sci Immunol. 2021; 6:eabf7235.","DOI":"10.1126\/sciimmunol.abf7235"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Hughes SA, Lin M, Weir A, <i>et al.<\/i> Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1\u03b2 release in X-linked inhibitor of apoptosis (XIAP) deficiency. EMBO J. 2023; 42:e110468.","DOI":"10.15252\/embj.2021110468"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B, Teng F, Lyu M, Yano H, Andreasson KI, Mekada E, Eberl G, Sonnenberg G<i>.<\/i> Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol. 2022; 23:251-261.","DOI":"10.1038\/s41590-021-01110-0"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR<i>.<\/i> Inflammation-induced occludin downregulation limits epithelial apoptosis by suppressing caspase-3 expression. Gastroenterology. 2019; 157:1323-1337.","DOI":"10.1053\/j.gastro.2019.07.058"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Blander JM. Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease. FEBS J. 2016; 283:2720-2730.","DOI":"10.1111\/febs.13771"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Chen X, Liu G, Yuan Y, Wu G, Wang S, Yuan L<i>.<\/i> NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease <i>via<\/i> NF-\u03baB signaling. Cell Death Dis. 2019; 10:906.","DOI":"10.1038\/s41419-019-2157-1"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Fontes A, Jauch AT, Sailer J, Engler J, Azul AM, Zischka H<i>.<\/i> Metabolic derangement of essential transition metals and potential antioxidant therapies. Int J Mol Sci. 2024; 25:7880.","DOI":"10.3390\/ijms25147880"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Li H, Chan L, Bartuzi P, <i>et al.<\/i> Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. 2014; 147:184-195.e3.","DOI":"10.1053\/j.gastro.2014.04.007"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Liu X, Nie L, Zhang Y, <i>et al.<\/i> Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023; 25:404-414.","DOI":"10.1038\/s41556-023-01091-2"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. L\u00f3pez-Polo V, Maus M, Zacharioudakis E, Lafarga M, Attolini CS, Marques FDM, Kovatcheva M, Gavathiotis E, Serrano M<i>.<\/i> Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells. Nat Commun. 2024; 15:7378.","DOI":"10.1038\/s41467-024-51363-0"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Moschandrea C, Kondylis V, Evangelakos I, <i>et al.<\/i> Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 2024; 625:385-392.","DOI":"10.1038\/s41586-023-06857-0"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Correia\u2010Melo C, Marques FD, Anderson R, <i>et al.<\/i> Mitochondria are required for pro\u2010ageing features of the senescent phenotype. EMBO J. 2016; 35:724-742.","DOI":"10.15252\/embj.201592862"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL<i>.<\/i> Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy. Sci Rep. 2023; 13:18.","DOI":"10.1038\/s41598-022-26775-x"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Wands D, Lau SY, Chuah CS, <i>et al.<\/i> P0065 Circulating cell-free DNA and mitochondrial DNA differentiate disease activity in paediatric-onset inflammatory bowel disease: Interim analysis from Scotland-wide Mini-MUSIC study (2020-26). J Crohns Colitis. 2025; 19(Supp 1):i427.","DOI":"10.1093\/ecco-jcc\/jjae190.0239"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Dimitrov G, Ryffel B, Togbe D, Quesniaux V. cGAS-STING DNA-sensing in inflammatory bowel diseases. Trends Mol Med. 2025; 31:165-180.","DOI":"10.1016\/j.molmed.2024.10.002"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Springer E, Bornh\u00e4user J, Bakr M, <i>et al.<\/i> P0078 The role of epithelial STING in a genetic IBD Model of autophagy deficiency and its interplay with the Integrated stress response. J Crohns Colitis. 2025; 19(Supp 1):i443-444.","DOI":"10.1093\/ecco-jcc\/jjae190.0252"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Ho GT, Theiss AL. Mitochondria and inflammatory bowel diseases: Toward a stratified therapeutic intervention. Annu Rev Physiol. 2022; 84:435-459.","DOI":"10.1146\/annurev-physiol-060821-083306"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Liu J. Aged garlic therapeutic intervention targeting inflammatory pathways in pathogenesis of bowel disorders. Heliyon. 2024; 10:e33986.","DOI":"10.1016\/j.heliyon.2024.e33986"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Wen X, Tang L, Zhong R, Liu L, Chen L, Zhang H<i>.<\/i> Role of mitophagy in regulating intestinal oxidative damage. Antioxid Basel Switz. 2023; 12:480.","DOI":"10.3390\/antiox12020480"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Zhang J, Jiang Y, Fan D, Qiu Z, He X, Liu S, Li L, Dai Z, Zhang L, Shu Z, Li L, Zhang H, Yang T, Luo Y<i>.<\/i> Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment. Cell Rep Med. 2024; 5:101840.","DOI":"10.1016\/j.xcrm.2024.101840"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Lin L, Ren R, Xiong Q, Zheng C, Yang B, Wang H<i>.<\/i> Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases. Autoimmun Rev. 2024;23:103583.","DOI":"10.1016\/j.autrev.2024.103583"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Danne C, Michaudel C, Skerniskyte J, <i>et al.<\/i> CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival. Gut. 2023; 72:1081-1092.","DOI":"10.1136\/gutjnl-2022-326917"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Hirose M, Sekar P, Eladham MWA, Albataineh MT, Rahmani M, Ibrahim SM<i>.<\/i> Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease. J Mol Med Berl Ger. 2023; 101:1513-1526.","DOI":"10.1007\/s00109-023-02381-w"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Olecka M, van B\u00f6mmel A, Best L, Haase M, Foerste S, Riege K, Dost T, Flor S, Witte OW, Franzenburg S, Groth M, von Eyss B, Kaleta C, Frahm C, Hoffmann S<i>.<\/i> Nonlinear DNA methylation trajectories in aging male mice. Nat Commun. 2024; 15:3074.","DOI":"10.1038\/s41467-024-47316-2"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Pentinmikko N, Iqbal S, Mana M, <i>et al.<\/i> Paneth cell produced Notum attenuates regeneration of aged intestinal epithelium. Nature. 2019; 571:398-402.","DOI":"10.1038\/s41586-019-1383-0"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H<i>.<\/i> Canonical Wnt signaling ameliorates aging of intestinal stem cells. Cell Rep. 2017; 18:2608-2621.","DOI":"10.1016\/j.celrep.2017.02.056"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Cai Y, Xiong M, Xin Z, <i>et al.<\/i> Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023; 30:1674-1691.e8.","DOI":"10.1016\/j.stem.2023.09.014"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Chopra Y, Acevedo K, Muise A, Frost K, Schechter T, Krueger J, Ali M, Chiang KY, Kim VH, Grunebaum E, Wall D<i>.<\/i> Gut immunomodulation with vedolizumab prior to allogeneic hematopoietic stem cell transplantation in pediatric patients with inflammatory bowel disease. Transplant Cell Ther. 2024; 30:546.e1-546.e7.","DOI":"10.1016\/j.jtct.2024.03.006"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Liu A, Lv H, Wang H, Yang H, Li Y, Qian J<i>.<\/i> Aging increases the severity of colitis and the related changes to the gut barrier and gut microbiota in humans and mice. J Gerontol A Biol Sci Med Sci. 2020; 75:1284-1292.","DOI":"10.1093\/gerona\/glz263"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Liu X, Ma Y, Guan K, Liu R, Mao K, Xu X, Li Q, Wang R<i>.<\/i> Intestinal barrier, immunity and gut microbiota-based protective effects of Lactococcus lactis HF08 and its postbiotic derivative on aging and aging colitis mice. Food Res Int Ott Ont. 2024; 197:115164.","DOI":"10.1016\/j.foodres.2024.115164"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Dambroise E, Monnier L, Ruisheng L, Aguilaniu H, Joly JS, Tricoire H, Rera M<i>.<\/i> Two phases of aging separated by the Smurf transition as a public path to death. Sci Rep. 2016; 6:23523.","DOI":"10.1038\/srep23523"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Xu T, Ning X, Wu J, Wang Q, Wang Z, Chen Z, Tang X, Bai P, Pu K, Li L, Zhang R<i>.<\/i> Metabolic nanoregulator remodels gut microenvironment for treatment of inflammatory bowel disease. ACS Nano. 2024; 18:7123-7135.","DOI":"10.1021\/acsnano.3c11496"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Duan C, Kuang L, Xiang X, Zhang J, Zhu Y, Wu Y, Yan Q, Liu L, Li T<i>.<\/i> Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock. Aging. 2020; 12:1397-1416.","DOI":"10.18632\/aging.102690"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Homolak J. Gastrointestinal redox homeostasis in ageing. Biogerontology. 2023; 24:741-752.","DOI":"10.1007\/s10522-023-10049-8"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101. Chen Y, Cui W, Li X, Yang H<i>.<\/i> Interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease. Front Immunol. 2021; 12:761981.","DOI":"10.3389\/fimmu.2021.761981"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102. Macias-Ceja DC, Mendoza-Ballesteros MT, Ortega-Albiach M, <i>et al.<\/i> Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: Relevance of the epithelial-to mesenchymal transition. Front Cell Dev Biol. 2023; 11:1258843.","DOI":"10.3389\/fcell.2023.1258843"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103. Parikh K, Antanaviciute A, Fawkner-Corbett D, <i>et al.<\/i> Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature. 2019; 567:49-55.","DOI":"10.1038\/s41586-019-0992-y"},{"key":"104","doi-asserted-by":"crossref","unstructured":"104. Loh JS, Mak WQ, Tan LKS, Ng CX, Chan HH, Yeow SH, Foo JB, Ong YS, How CW, Khaw KY<i>.<\/i> Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduct Target Ther. 2024; 9:37.","DOI":"10.1038\/s41392-024-01743-1"},{"key":"105","doi-asserted-by":"crossref","unstructured":"105. Arnauts K, Sudhakar P, Verstockt S, Lapierre C, Potche S, Caenepeel C, Verstockt B, Raes J, Vermeire S, Sabino J, Verfaillie C, Ferrante M<i>.<\/i> Microbiota, not host origin drives ex vivo intestinal epithelial responses. Gut Microbes. 2022; 14:2089003.","DOI":"10.1080\/19490976.2022.2089003"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106. Zheng H, Zhang C, Wang Q, Feng S, Fang Y, Zhang S<i>.<\/i> The impact of aging on intestinal mucosal immune function and clinical applications. Front Immunol. 2022; 13:1029948.","DOI":"10.3389\/fimmu.2022.1029948"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107. Mehandru S, Colombel JF. The intestinal barrier, an arbitrator turned provocateur in IBD. Nat Rev Gastroenterol Hepatol. 2021; 18:83-4.","DOI":"10.1038\/s41575-020-00399-w"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108. Arnold JW, Roach J, Fabela S, Moorfield E, Ding S, Blue E, Dagher S, Magness S, Tamayo R, Bruno-Barcena JM, Azcarate-Peril MA<i>.<\/i> The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut. Microbiome. 2021; 9:31.","DOI":"10.1186\/s40168-020-00980-0"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109. Gong H, Gan X, Qin B, Chen J, Zhao Y, Qiu B, Chen W, Yu Y, Shi S, Li T, Liu D, Li B, Wang S, Wang H<i>.<\/i> Structural characteristics of steamed Polygonatum cyrtonema polysaccharide and its bioactivity on colitis <i>via<\/i> improving the intestinal barrier and modifying the gut microbiota. Carbohydr Polym. 2024; 327:121669.","DOI":"10.1016\/j.carbpol.2023.121669"},{"key":"110","doi-asserted-by":"crossref","unstructured":"110. Rath T, Atreya R, Neurath MF. A spotlight on intestinal permeability and inflammatory bowel diseases. Expert Rev Gastroenterol Hepatol. 2023; 17:893-902.","DOI":"10.1080\/17474124.2023.2242772"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111. Vancamelbeke M, Vanuytsel T, Farr\u00e9 R, Verstockt S, Ferrante M, Van Assche G, Rutgeerts P, Schuit F, Vermeire S, Arijs I, Cleynen I<i>.<\/i> Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease. Inflamm Bowel Dis. 2017; 23:1718-29.","DOI":"10.1097\/MIB.0000000000001246"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112. Santos TWD, Pereira QC, Fortunato IM, Oliveira FS, Alvarez MC, Ribeiro ML<i>.<\/i> Body composition and senescence: Impact of polyphenols on aging-associated events. Nutrients. 2024; 16:3621.","DOI":"10.3390\/nu16213621"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113. Schaum N, Lehallier B, Hahn O, <i>et al.<\/i> Aging hallmarks exhibit organ-specific temporal signatures. Nature. 2020; 583:596-602.","DOI":"10.1038\/s41586-020-2499-y"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114. Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I<i>.<\/i> Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Am J Physiol Gastrointest Liver Physiol. 2015; 308:G591-G604.","DOI":"10.1152\/ajpgi.00269.2014"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115. Kredel LI, Siegmund B. Adipose-tissue and intestinal inflammation - Visceral obesity and creeping fat. Front Immunol. 2014; 5:462.","DOI":"10.3389\/fimmu.2014.00462"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116. Ruggiero AD, Key CCC, Kavanagh K. Adipose tissue macrophage polarization in healthy and unhealthy obesity. Front Nutr. 2021; 8:625331.","DOI":"10.3389\/fnut.2021.625331"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117. Khan S, Chan YT, Revelo XS, Winer DA<i>.<\/i> The immune landscape of visceral adipose tissue during obesity and aging. Front Endocrinol. 2020; 11:267.","DOI":"10.3389\/fendo.2020.00267"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118. Losev V, Lu C, Tahasildar S, Senevirathne DS, Inglese P, Bai W, King AP, Shah M, de Marvao A, O&apos;Regan DP<i>.<\/i> Sex-specific body fat distribution predicts cardiovascular ageing. Eur Heart J. 2025; ehaf553.","DOI":"10.1093\/eurheartj\/ehaf553"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119. Yang L, Liu G, Zhang Y, Yao B, Wu Q, Peng L, Wang X, Yuan L<i>.<\/i> Quantitative analysis of adipose tissue for predicting Crohn&apos;s disease postoperative endoscopic recurrence and anastomotic ulcer. Int J Colorectal Dis. 2023; 38:170.","DOI":"10.1007\/s00384-023-04456-z"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120. Hwang N, Kang D, Shin SJ, Yoon BK, Chun J, Kim JW, Fang S<i>.<\/i> Creeping fat exhibits distinct Inflammation-specific adipogenic preadipocytes in Crohn&apos;s disease. Front Immunol. 2023; 14:1198905.","DOI":"10.3389\/fimmu.2023.1198905"},{"key":"121","doi-asserted-by":"crossref","unstructured":"121. Ha CWY, Martin A, Sepich-Poore GD, <i>et al.<\/i> Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans. Cell. 2020; 183:666-683.e17.","DOI":"10.1016\/j.cell.2020.09.009"},{"key":"122","doi-asserted-by":"crossref","unstructured":"122. Dowling L, Jakeman P, Norton C, Skelly MM, Yousuf H, Kiernan MG, Toomey M, Bowers S, Dunne SS, Coffey JC, Dunne CP<i>.<\/i> Adults with Crohn&apos;s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission. Sci Rep. 2021; 11:19258.","DOI":"10.1038\/s41598-021-98798-9"},{"key":"123","doi-asserted-by":"crossref","unstructured":"123. Caprara G, Allavena P, Erreni M. Intestinal macrophages at the crossroad between diet, inflammation, and cancer. Int J Mol Sci. 2020; 21:4825.","DOI":"10.3390\/ijms21144825"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124. Xiong Z, Wu P, Zhang Y, Chen J, Shen Y, Kamel I, Wu B, Zheng X, Li Z<i>.<\/i> Radiological biomarkers reflecting visceral fat distribution help distinguish inflammatory bowel disease subtypes: A multicenter cross-sectional study. Insights Imaging. 2024; 15:70.","DOI":"10.1186\/s13244-024-01640-9"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125. Wu F, Wu F, Zhou Q, Liu X, Fei J, Zhang D, Wang W, Tao Y, Lin Y, Lin Q, Pan X, Sun K, Xie F, Bai L<i>.<\/i> A CCL2+DPP4+ subset of mesenchymal stem cells expedites aberrant formation of creeping fat in humans. Nat Commun. 2023; 14:5830.","DOI":"10.1038\/s41467-023-41418-z"},{"key":"126","doi-asserted-by":"crossref","unstructured":"126. Valentini L, Wirth EK, Schweizer U, Hengstermann S, Schaper L, Koernicke T, Dietz E, Norman K, Buning C, Winklhofer-Roob BM, Lochs H, Ockenga J<i>.<\/i> Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease. Nutr Burbank Los Angel Cty Calif. 2009; 25:172-181.","DOI":"10.1016\/j.nut.2008.07.020"},{"key":"127","doi-asserted-by":"crossref","unstructured":"127. Niu C, Xu W, Xiong S. Appendectomy mitigates Coxsackievirus B3-induced viral myocarditis. Viruses. 2023; 15:1974.","DOI":"10.3390\/v15101974"},{"key":"128","doi-asserted-by":"crossref","unstructured":"128. Mahmud MR, Akter S, Tamanna SK, Mazumder L, Esti IZ, Banerjee S, Akter S, Hasan MR, Acharjee M, Hossain MS, Pirttil\u00e4 AM<i>.<\/i> Impact of gut microbiome on skin health: Gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes. 2022; 14:2096995.","DOI":"10.1080\/19490976.2022.2096995"},{"key":"129","doi-asserted-by":"crossref","unstructured":"129. Collard MK, Bardin J, Laurin M, Ogier-Denis E<i>.<\/i> The cecal appendix is correlated with greater maximal longevity in mammals. J Anat. 2021; 239:1157-69.","DOI":"10.1111\/joa.13501"},{"key":"130","doi-asserted-by":"crossref","unstructured":"130. Girard-Madoux MJH, Gomez de Ag\u00fcero M, Ganal-Vonarburg SC, Mooser C, Belz GT, Macpherson AJ, Vivier E<i>.<\/i> The immunological functions of the appendix: An example of redundancy? Semin Immunol. 2018; 36:31-44.","DOI":"10.1016\/j.smim.2018.02.005"},{"key":"131","doi-asserted-by":"crossref","unstructured":"131. Senda T, Dogra P, Granot T, Furuhashi K, Snyder ME, Carpenter DJ, Szabo PA, Thapa P, Miron M, Farber DL<i>.<\/i> Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life. Mucosal Immunol. 2019; 12:378-389.","DOI":"10.1038\/s41385-018-0110-8"},{"key":"132","doi-asserted-by":"crossref","unstructured":"132. Demyashkin G, Gorokhov K, Shchekin V, Vadyukhin M, Matevosyan A, Rudavina A, Pilipchuk A, Pilipchuk A, Kochetkova S, Atiakshin D, Shegay P, Kaprin A<i>.<\/i> Features of appendix and the characteristics of appendicitis development in children with COVID-19. Biomedicines. 2024; 12:312.","DOI":"10.3390\/biomedicines12020312"},{"key":"133","doi-asserted-by":"crossref","unstructured":"133. Chung WS, Chung S, Hsu CY, Lin CL<i>.<\/i> Risk of inflammatory bowel disease following appendectomy in adulthood. Front Med. 2021; 8:661752.","DOI":"10.3389\/fmed.2021.661752"},{"key":"134","doi-asserted-by":"crossref","unstructured":"134. Cheluvappa R, Luo AS, Grimm MC. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol. 2014; 175:316-322.","DOI":"10.1111\/cei.12237"},{"key":"135","doi-asserted-by":"crossref","unstructured":"135. Cheluvappa R. Identification of new potential therapies for colitis amelioration using an appendicitis-appendectomy model. Inflamm Bowel Dis. 2019; 25:436-444.","DOI":"10.1093\/ibd\/izy332"},{"key":"136","doi-asserted-by":"crossref","unstructured":"136. Zhang Y, Yang L, Yuan L. Investigating the causal relationship between inflammatory bowel disease and simple appendicitis using Mendelian randomization. Sci Rep. 2024; 14:23617.","DOI":"10.1038\/s41598-024-74572-5"},{"key":"137","doi-asserted-by":"crossref","unstructured":"137. Kiasat A, Ekstr\u00f6m LD, Marsk R, L\u00f6f-Granstr\u00f6m A, Gustafsson UO<i>.<\/i> Childhood appendicitis and future risk of inflammatory bowel disease - A nationwide cohort study in Sweden 1973-2017. Colorectal Dis Off J Assoc Coloproctology G B Irel. 2022; 24:975-983.","DOI":"10.1111\/codi.16128"},{"key":"138","doi-asserted-by":"crossref","unstructured":"138. van der Does de Willebois EML, Sari C, Mookhoek A, Joustra V, van Dieren S, D&apos;Haens GR, Bemelman WA, Buskens CJ<i>.<\/i> The clinical relevance of an inflamed appendix in Crohn&apos;s disease. J Crohns Colitis. 2024; 18:812-817.","DOI":"10.1093\/ecco-jcc\/jjad202"},{"key":"139","doi-asserted-by":"crossref","unstructured":"139. Mark-Christensen A, Kristiansen EB, Myrelid P, Laurberg S, Erichsen R<i>.<\/i> Appendectomy and Risk of advanced colorectal neoplasia in inflammatory bowel disease: A nationwide population-based cohort study. Inflamm Bowel Dis. 2024; 30:877-883.","DOI":"10.1093\/ibd\/izad141"},{"key":"140","doi-asserted-by":"crossref","unstructured":"140. Nyboe Andersen N, G\u00f8rtz S, Frisch M, Jess T<i>.<\/i> Reduced risk of UC in families affected by appendicitis: A Danish national cohort study. Gut. 2017; 66:1398-402.","DOI":"10.1136\/gutjnl-2015-311131"},{"key":"141","doi-asserted-by":"crossref","unstructured":"141. Roderburg C, Loosen SH, May P, Yaqubi K, Luedde T, Kostev K<i>.<\/i> The nexus between appendicitis and chronic inflammatory bowel diseases: Unraveling an intriguing association. Medicine (Baltimore). 2024; 103:e38859.","DOI":"10.1097\/MD.0000000000038859"},{"key":"142","doi-asserted-by":"crossref","unstructured":"142. Deng P, Wu J. Meta-analysis of the association between appendiceal orifice inflammation and appendectomy and ulcerative colitis. Rev Esp Enferm Dig. 2016; 108:401-10.","DOI":"10.17235\/reed.2016.4176\/2015"},{"key":"143","doi-asserted-by":"crossref","unstructured":"143. Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A<i>.<\/i> Cellular senescence: Aging, cancer, and injury. Physiol Rev. 2019; 99:1047-1078.","DOI":"10.1152\/physrev.00020.2018"},{"key":"144","doi-asserted-by":"crossref","unstructured":"144. Shay JW. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 2016; 6:584-593.","DOI":"10.1158\/2159-8290.CD-16-0062"},{"key":"145","doi-asserted-by":"crossref","unstructured":"145. Chakravarti D, LaBella KA, DePinho RA. Telomeres: History, health, and hallmarks of aging. Cell. 2021; 184:306-322.","DOI":"10.1016\/j.cell.2020.12.028"},{"key":"146","doi-asserted-by":"crossref","unstructured":"146. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC<i>.<\/i> Telomere reduction in human colorectal carcinoma and with ageing. Nature. 1990; 346:866-868.","DOI":"10.1038\/346866a0"},{"key":"147","doi-asserted-by":"crossref","unstructured":"147. Lian J, Yue Y, Yu W, Zhang Y<i>.<\/i> Immunosenescence: A key player in cancer development. J Hematol OncolJ Hematol Oncol. 2020; 13:151.","DOI":"10.1186\/s13045-020-00986-z"},{"key":"148","doi-asserted-by":"crossref","unstructured":"148. Ziegler DV, Vindrieux D, Goehrig D, <i>et al.<\/i> Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging. Nat Commun. 2021; 12:720.","DOI":"10.1038\/s41467-021-20993-z"},{"key":"149","doi-asserted-by":"crossref","unstructured":"149. Shah SC, Itzkowitz SH. Colorectal cancer in inflammatory bowel disease: mechanisms and management. Gastroenterology. 2022; 162:715-730.e3.","DOI":"10.1053\/j.gastro.2021.10.035"},{"key":"150","doi-asserted-by":"crossref","unstructured":"150. Lasry A, Zinger A, Ben-Neriah Y. Inflammatory networks underlying colorectal cancer. Nat Immunol. 2016; 17:230-240.","DOI":"10.1038\/ni.3384"},{"key":"151","doi-asserted-by":"crossref","unstructured":"151. Becker WR, Nevins SA, Chen DC, <i>et al.<\/i> Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. Nat Genet. 2022; 54:985-995.","DOI":"10.1038\/s41588-022-01088-x"},{"key":"152","doi-asserted-by":"crossref","unstructured":"152. Wu M, Li J, An Y, Li P, Xiong W, Li J, Yan D, Wang M, Zhong G<i>.<\/i> Chitooligosaccharides prevents the development of colitis-associated colorectal cancer by modulating the intestinal microbiota and mycobiota. Front Microbiol. 2019; 10:2101.","DOI":"10.3389\/fmicb.2019.02101"},{"key":"153","doi-asserted-by":"crossref","unstructured":"153. Wieczorska K, Stolarek M, Stec R. The role of the gut microbiome in colorectal cancer: Where are we? Where are we going? Clin Colorectal Cancer. 2020; 19:5-12.","DOI":"10.1016\/j.clcc.2019.07.006"},{"key":"154","doi-asserted-by":"crossref","unstructured":"154. Arthur JC, Perez-Chanona E, M\u00fchlbauer M, <i>et al.<\/i> Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 2012; 338:120-123.","DOI":"10.1126\/science.1224820"},{"key":"155","doi-asserted-by":"crossref","unstructured":"155. Rajam\u00e4ki K, Taira A, Katainen R, <i>et al.<\/i> Genetic and epigenetic characteristics of inflammatory bowel disease-associated colorectal cancer. Gastroenterology. 2021; 161:592-607.","DOI":"10.1053\/j.gastro.2021.04.042"},{"key":"156","doi-asserted-by":"crossref","unstructured":"156. Jackson MA, Jeffery IB, Beaumont M, Bell JT, Clark AG, Ley RE, O&apos;Toole PW, Spector TD, Steves CJ<i>.<\/i> Signatures of early frailty in the gut microbiota. Genome Med. 2016; 8:8.","DOI":"10.1186\/s13073-016-0262-7"},{"key":"157","doi-asserted-by":"crossref","unstructured":"157. O&apos;Toole PW, Jeffery IB. Gut microbiota and aging. Science. 2015; 350:1214-1215.","DOI":"10.1126\/science.aac8469"},{"key":"158","doi-asserted-by":"crossref","unstructured":"158. Zhang L, Liao J, Chen Q, Chen M, Kuang Y, Chen L, He W<i>.<\/i> Characterization of the gut microbiota in frail elderly patients. Aging Clin Exp Res. 2020; 32:2001-2011.","DOI":"10.1007\/s40520-019-01385-2"},{"key":"159","doi-asserted-by":"crossref","unstructured":"159. Hinssen F, Mensink M, Huppertz T, van der Wielen N. Impact of aging on the digestive system related to protein digestion in vivo. Crit Rev Food Sci Nutr. 2025; 65:5871-5887","DOI":"10.1080\/10408398.2024.2433598"},{"key":"160","doi-asserted-by":"crossref","unstructured":"160. McKay LF, Smith RG, Eastwood MA, Walsh SD, Cruikshank JG<i>.<\/i> An investigation of colonic function in the elderly. Age Ageing. 1983; 12:105-110.","DOI":"10.1093\/ageing\/12.2.105"},{"key":"161","doi-asserted-by":"crossref","unstructured":"161. Palmela C, Chevarin C, Xu Z, Torres J, Sevrin G, Hirten R, Barnich N, Ng SC, Colombel JF<i>.<\/i> Adherent-invasive Escherichia coli in inflammatory bowel disease. Gut. 2018; 67:574-587.","DOI":"10.1136\/gutjnl-2017-314903"},{"key":"162","doi-asserted-by":"crossref","unstructured":"162. Vieujean S, Gillard R, Delanaye P, Seidel L, Bequet E, Sal\u00e9e C, Meuwis MA, Massot C, Pierre N, Meunier P, Cavalier E, Louis E<i>.<\/i> Matrix gla protein, a potential marker of tissue remodelling and physiological ageing of the gut in Crohn&apos;s disease. Scand J Gastroenterol. 2024; 59:296-303.","DOI":"10.1080\/00365521.2023.2286913"},{"key":"163","doi-asserted-by":"crossref","unstructured":"163. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D&apos;Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ, Auwerx J<i>.<\/i> NAD<sup>+<\/sup> repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016; 352:1436-1443.","DOI":"10.1126\/science.aaf2693"},{"key":"164","doi-asserted-by":"crossref","unstructured":"164. Ma L, Ni Y, Wang Z, Tu W, Ni L, Zhuge F, Zheng A, Hu L, Zhao Y, Zheng L, Fu Z<i>.<\/i> Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice. Gut Microbes. 2020; 12:1-19.","DOI":"10.1080\/19490976.2020.1832857"},{"key":"165","doi-asserted-by":"crossref","unstructured":"165. Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD<i>.<\/i> Targeting cellular senescence with senotherapeutics: Senolytics and senomorphics. FEBS J. 2023; 290:1362-1383.","DOI":"10.1111\/febs.16350"},{"key":"166","doi-asserted-by":"crossref","unstructured":"166. Sun Q, Bravo Iniguez A, Tian Q, Du M, Zhu MJ<i>.<\/i> Dietary cannabidiol activates PKA\/AMPK signaling and attenuates chronic inflammation and leaky gut in DSS-induced colitis mice. Mol Nutr Food Res. 2024; 68:e2300446.","DOI":"10.1002\/mnfr.202300446"},{"key":"167","doi-asserted-by":"crossref","unstructured":"167. Serrano C, Gal\u00e1n S, Rubio JF, Candelario-Mart\u00ednez A, Montes-G\u00f3mez AE, Ch\u00e1nez-Paredes S, Cedillo-Barr\u00f3n L, Schnoor M, Meraz-R\u00edos MA, Villegas-Sep\u00falveda N, Ortiz- Navarrete V, Nava P. Compartmentalized Response of IL-6\/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development. J Immunol. 2019; 202:1239-1249","DOI":"10.4049\/jimmunol.1801060"},{"key":"168","doi-asserted-by":"crossref","unstructured":"168. Ocansey DKW, Wang L, Wang J, <i>et al.<\/i> Mesenchymal stem cell-gut microbiota interaction in the repair of inflammatory bowel disease: An enhanced therapeutic effect. Clin Transl Med. 2019; 8:31.","DOI":"10.1186\/s40169-019-0251-8"},{"key":"169","doi-asserted-by":"crossref","unstructured":"169. Kim ME, Lee JS. Immune diseases associated with aging: Molecular mechanisms and treatment strategies. Int J Mol Sci. 2023; 24:15584.","DOI":"10.3390\/ijms242115584"},{"key":"170","doi-asserted-by":"crossref","unstructured":"170. Ou Q, Power R, Griffin MD. Revisiting regulatory T cells as modulators of innate immune response and inflammatory diseases. Front Immunol. 2023;14:1287465.","DOI":"10.3389\/fimmu.2023.1287465"},{"key":"171","doi-asserted-by":"crossref","unstructured":"171. Salminen A. Activation of immunosuppressive network in the aging process. Ageing Res Rev. 2020; 57:100998.","DOI":"10.1016\/j.arr.2019.100998"},{"key":"172","doi-asserted-by":"crossref","unstructured":"172. Rybtsova N, Berezina TN, Rybtsov S. Molecular markers of blood cell populations can help estimate aging of the immune system. Int J Mol Sci. 2023; 24:5708.","DOI":"10.3390\/ijms24065708"},{"key":"173","doi-asserted-by":"crossref","unstructured":"173. Angelovich TA, Shi MD, Zhou J, Maisa A, Hearps AC, Jaworowski A<i>. Ex vivo<\/i> foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms. Exp Gerontol. 2016; 80:17-26.","DOI":"10.1016\/j.exger.2016.04.006"},{"key":"174","doi-asserted-by":"crossref","unstructured":"174. Liu B, Zhu L, Lei L, Li H, Cong R, Hou J, Zhao J, Li P, Tang Y, Su Z, Tu J, Jiang L. Lesional Macrophage-Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis. Adv Mater. 2025; 37:e2502581.","DOI":"10.1002\/adma.202502581"},{"key":"175","doi-asserted-by":"crossref","unstructured":"175. Islam SMS, Ryu HM, Sohn S. Tetragenococcus halophilus alleviates intestinal inflammation in mice by altering gut microbiota and regulating dendritic cell activation <i>via<\/i> CD83. Cells. 2022; 11:1903.","DOI":"10.3390\/cells11121903"},{"key":"176","doi-asserted-by":"crossref","unstructured":"176. Kiilerich KF, Andresen T, Darbani B, Gregersen LHK, Liljens\u00f8e A, Bennike TB, Holm R, Moeller JB, Andersen V<i>.<\/i> Advancing inflammatory bowel disease treatment by targeting the innate immune system and precision drug delivery. Int J Mol Sci. 2025; 26:575.","DOI":"10.3390\/ijms26020575"},{"key":"177","doi-asserted-by":"crossref","unstructured":"177. Krueger ME, Boles JS, Simon ZD, Alvarez SD, McFarland NR, Okun MS, Zimmermann EM, Forsmark CE, Tansey MG<i>.<\/i> Comparative analysis of Parkinson&apos;s and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion. NPJ Park Dis. 2025; 11:50.","DOI":"10.1038\/s41531-025-00894-4"},{"key":"178","doi-asserted-by":"crossref","unstructured":"178. Yan H, Qin Q, Yan S, Chen J, Yang Y, Li T, Gao X, Ding S<i>.<\/i> Comparison of the gut microbiota in different age groups in China. Front Cell Infect Microbiol. 2022; 12:877914.","DOI":"10.3389\/fcimb.2022.877914"},{"key":"179","doi-asserted-by":"crossref","unstructured":"179. Zhang K, Dong Y, Ding Y, Wang X, Liu T, Zhong W, Cao H<i>.<\/i> Illuminating prospects of probiotic Akkermansia muciniphila in intestinal inflammation and carcinogenesis. Microbiol Res. 2025; 299:128240.","DOI":"10.1016\/j.micres.2025.128240"},{"key":"180","doi-asserted-by":"crossref","unstructured":"180. Zhu L, Xu LZ, Zhao S, Shen ZF, Shen H, Zhan LB<i>.<\/i> Protective effect of baicalin on the regulation of Treg\/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis. Appl Microbiol Biotechnol. 2020; 104:5449-5460.","DOI":"10.1007\/s00253-020-10527-w"},{"key":"181","doi-asserted-by":"crossref","unstructured":"181. Konstanti P, G\u00f3mez-Mart\u00ednez C, Muralidharan J, <i>et al.<\/i> Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome. Sci Rep. 2024; 14:28075.","DOI":"10.1038\/s41598-024-78527-8"},{"key":"182","doi-asserted-by":"crossref","unstructured":"182. L\u00e1z\u00e1r B, L\u00e1szl\u00f3 SB, Hutka B, <i>et al.<\/i> A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine. Biochem Pharmacol. 2021; 190:114590.","DOI":"10.1016\/j.bcp.2021.114590"},{"key":"183","doi-asserted-by":"crossref","unstructured":"183. Chen W, Wei Y, Xiong A, <i>et al.<\/i> Comprehensive analysis of serum and fecal bile acid profiles and interaction with gut microbiota in primary biliary cholangitis. Clin Rev Allergy Immunol. 2020; 58:25-38.","DOI":"10.1007\/s12016-019-08731-2"},{"key":"184","doi-asserted-by":"crossref","unstructured":"184. Zhong Y, Chang X, Zhao Z, Zheng L, Kuang G, Li P, Liu C, Fan Y, Liang Z, Zhuang K, Xie Q, Liu Y<i>. Bacteroides fragilis<\/i> capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota. Front Pharmacol. 2024; 15:1402465.","DOI":"10.3389\/fphar.2024.1402465"},{"key":"185","doi-asserted-by":"crossref","unstructured":"185. Yan Y, Tian L, Zhao Y, <i>et al.<\/i> Bacteroides fragilis toxin suppresses METTL3-mediated m6A modification in macrophage to promote inflammatory bowel disease. J Crohns Colitis. 2025; 19:jjae179.","DOI":"10.1093\/ecco-jcc\/jjae179"},{"key":"186","doi-asserted-by":"crossref","unstructured":"186. Abdi M, Lohrasbi V, Asadi A, Esghaei M, Jazi FM, Rohani M, Talebi M<i>.<\/i> Interesting probiotic traits of mother&apos;s milk Lactobacillus isolates; From bacteriocin to inflammatory bowel disease improvement. Microb Pathog. 2021; 158:104998.","DOI":"10.1016\/j.micpath.2021.104998"},{"key":"187","doi-asserted-by":"crossref","unstructured":"187. Lakshminarayanan B, Guinane CM, O&apos;Connor PM, Coakley M, Hill C, Stanton C, O&apos;Toole PW, Ross RP<i>.<\/i> Isolation and characterization of bacteriocin-producing bacteria from the intestinal microbiota of elderly Irish subjects. J Appl Microbiol. 2013; 114:886-898.","DOI":"10.1111\/jam.12085"},{"key":"188","doi-asserted-by":"crossref","unstructured":"188. Jacobsen GE, Gonzalez EE, Mendygral P, <i>et al.<\/i> Deep sequencing of Crohn&apos;s disease lamina propria phagocytes identifies pathobionts and correlates with pro-inflammatory gene expression. Inflamm Bowel Dis. 2025; 31:1203-1219.","DOI":"10.1093\/ibd\/izae316"},{"key":"189","doi-asserted-by":"crossref","unstructured":"189. Kumpitsch C, Fischmeister FPS, Mahnert A, Lackner S, Wilding M, Sturm C, Springer A, Madl T, Holasek S, H\u00f6genauer C, Berg IA, Schoepf V, Moissl-Eichinger C<i>.<\/i> Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans. Microbiome. 2021; 9:193.","DOI":"10.1186\/s40168-021-01130-w"},{"key":"190","doi-asserted-by":"crossref","unstructured":"190. Mohammadzadeh R, Mahnert A, Shinde T, Kumpitsch C, Weinberger V, Schmidt H, Moissl-Eichinger C<i>.<\/i> Age-related dynamics of predominant methanogenic archaea in the human gut microbiome. BMC Microbiol. 2025; 25:193.","DOI":"10.1186\/s12866-025-03921-9"},{"key":"191","doi-asserted-by":"crossref","unstructured":"191. Deleu S, Machiels K, Raes J, Verbeke K, Vermeire S<i>.<\/i> Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? EBioMedicine. 2021; 66:103293.","DOI":"10.1016\/j.ebiom.2021.103293"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/20\/1\/20_2025.01279\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:59:48Z","timestamp":1772859588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/20\/1\/20_2025.01279\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":191,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2025.01279","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"article-number":"2025.01279"}}