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Shin AE, Giancotti FG, Rustgi AK. Metastatic colorectal cancer: mechanisms and emerging therapeutics. Trends Pharmacol Sci. 2023; 44:222-236.","DOI":"10.1016\/j.tips.2023.01.003"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019; 394:1467-1480.","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. de Magalh\u00e3es JP. Cellular senescence in normal physiology. Science. 2024; 384:1300-1301.","DOI":"10.1126\/science.adj7050"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Suryadevara V, Hudgins AD, Rajesh A, <i>et al<\/i>. SenNet recommendations for detecting senescent cells in different tissues. Nat Rev Mol Cell Biol. 2024; 25:1001-1023.","DOI":"10.1038\/s41580-024-00738-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008; 319:1352-1355.","DOI":"10.1126\/science.1140735"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Takasugi M, Yoshida Y, Hara E, Ohtani N. The role of cellular senescence and SASP in tumour microenvironment. FEBS J. 2023; 290:1348-1361.","DOI":"10.1111\/febs.16381"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022; 12:31-46.","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Elia I, Haigis MC. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nat Metab. 2021; 3:21-32.","DOI":"10.1038\/s42255-020-00317-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Bergers G, Fendt SM. The metabolism of cancer cells during metastasis. Nat Rev Cancer. 2021; 21:162-180.","DOI":"10.1038\/s41568-020-00320-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tai R, Leng J, Li W, Wu Y, Yang J. Construction of the metabolic reprogramming-associated gene signature for clear cell renal cell carcinoma prognosis prediction. BMC Urol. 2023; 23:147.","DOI":"10.1186\/s12894-023-01317-3"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Wu Y, Yang S, Ma J, <i>et al<\/i>. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discov. 2022; 12:134-153.","DOI":"10.1158\/2159-8290.CD-21-0316"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. McInnes T, Zou D, Rao DS, Munro FM, Phillips VL, McCall JL, Black MA, Reeve AE, Guilford PJ. Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer. 2017; 17:228.","DOI":"10.1186\/s12885-017-3226-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Visone R, Bacalini MG, Di Franco S, <i>et al<\/i>. DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells. Epigenomics. 2019; 11:587-604.","DOI":"10.2217\/epi-2018-0153"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zhou Y, Ding Y, Xu B, Fei H, Wang Z. Genetically druggable targets for MAPK-activated colorectal cancer by a two-sample mendelian randomization analysis. Sci Rep. 2025; 15:12239.","DOI":"10.1038\/s41598-024-82567-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Maharati A, Moghbeli M. PI3K\/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells. Cell Commun Signal. 2023; 21:201.","DOI":"10.1186\/s12964-023-01225-x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Morabito M, Thibodot P, Gigandet A, Compagnon P, Toso C, Berishvili E, Lacotte S, Peloso A. Liver Extracellular Matrix in Colorectal Liver Metastasis. Cancers (Basel). 2025; 17:953.","DOI":"10.3390\/cancers17060953"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Kobayashi A, Mo YY, Fukuda K, Li Y, Watabe K. N-myc downstream regulated gene 1 modulates Wnt-\u03b2-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med. 2012; 4:93-108.","DOI":"10.1002\/emmm.201100190"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Wu K, Yan M, Liu T, <i>et al<\/i>. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nat Cell Biol. 2023; 25:714-725.","DOI":"10.1038\/s41556-023-01133-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Zhang L, Zhu Z, Yan H, <i>et al<\/i>. Creatine promotes cancer metastasis through activation of Smad2\/3. Cell Metab. 2021; 331111-1123.e4.","DOI":"10.1016\/j.cmet.2021.03.009"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ajona D, Ortiz-Espinosa S, Moreno H, Lozano T, Pajares MJ, Agorreta J, B\u00e9rtolo C, Lasarte JJ, Vicent S, Hoehlig K, Vater A, Lecanda F, Montuenga LM, Pio R. A Combined PD-1\/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis. Cancer Discov. 2017; 7:694-703.","DOI":"10.1158\/2159-8290.CD-16-1184"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Tauriello DVF, Palomo-Ponce S, Stork D, <i>et al<\/i>. TGF\u03b2 drives immune evasion in genetically reconstituted colon cancer metastasis. Nature. 2018; 554:538-543.","DOI":"10.1038\/nature25492"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wang S, Li J, Hong S, Wang N, Xu S, Yang B, Zheng Y, Zhang J, Pan B, Hu Y, Wang Z. Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM\/PD-L1 signaling. J Exp Clin Cancer Res. 2024; 43:121.","DOI":"10.1186\/s13046-024-03050-7"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bao Y, Zhai J, Chen H, Wong CC, Liang C, Ding Y, Huang D, Gou H, Chen D, Pan Y, Kang W, To KF, Yu J. Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut. 2023; 72:1497-1509.","DOI":"10.1136\/gutjnl-2022-328845"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ma J, Gao Q, Zeng S, Shen H. Knockdown of <i>NDRG1<\/i> promote epithelial-mesenchymal transition of colorectal cancer <i>via<\/i> NF-\u03baB signaling. J Surg Oncol. 2016; 114:520-527.","DOI":"10.1002\/jso.24348"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Qiao X, Hu Z, Xiong F, Yang Y, Peng C, Wang D, Li X. Lipid metabolism reprogramming in tumor-associated macrophages and implications for therapy. Lipids Health Dis. 2023; 22:45.","DOI":"10.1186\/s12944-023-01807-1"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Karadima E, Chavakis T, Alexaki VI. Arginine metabolism in myeloid cells in health and disease. Semin Immunopathol. 2025; 47:11.","DOI":"10.1007\/s00281-025-01038-9"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Heinemann V, von Weikersthal LF, Decker T, <i>et al<\/i>. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014; 15:1065-1075.","DOI":"10.1016\/S1470-2045(14)70330-4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Lu Z, Zou J, Li S, <i>et al<\/i>. Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020; 579:284-290.","DOI":"10.1038\/s41586-020-2054-x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Lichtenegger FS, Rothe M, Schnorfeil FM, Deiser K, Krupka C, Augsberger C, Schl\u00fcter M, Neitz J, Subklewe M. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells. Front Immunol. 2018; 9:385.","DOI":"10.3389\/fimmu.2018.00385"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Na D, Chae J, Cho SY, <i>et al<\/i>. Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers <i>via<\/i> profiling of patient-derived xenografts. 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