{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:54:08Z","timestamp":1790441648462,"version":"4.1.0"},"reference-count":32,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BST"],"published-print":{"date-parts":[[2026,2,28]]},"DOI":"10.5582\/bst.2025.01327","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:09:23Z","timestamp":1770329363000},"page":"105-121","source":"Crossref","is-referenced-by-count":1,"title":["Elevated alpha-fetoprotein affects the long-term prognosis after hepatectomy in patients with hepatitis B-related intrahepatic cholangiocarcinoma"],"prefix":"10.5582","volume":"20","author":[{"given":"Yizhe","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Hepatic Surgery IV, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery II, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai,China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery IV, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou,China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery IV, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery II, the Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai,China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME. Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians. CA Cancer J Clin. 2023; 73:198-222.","DOI":"10.3322\/caac.21759"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma. J Hepatol. 2023; 79:181-208.","DOI":"10.1016\/j.jhep.2023.03.010"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2024; 74:229-263.","DOI":"10.3322\/caac.21834"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Mazzaferro V, Gorgen A, Roayaie S, Droz Dit Busset M, Sapisochin G. Liver resection and transplantation for intrahepatic cholangiocarcinoma. Journal of hepatology. 2020; 72:364-377.","DOI":"10.1016\/j.jhep.2019.11.020"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis. J Hepatol. 2020; 72:95-103.","DOI":"10.1016\/j.jhep.2019.09.007"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Li M, Li J, Li P, Li H, Su T, Zhu R, Gong J. Hepatitis B virus infection increases the risk of cholangiocarcinoma: a meta-analysis and systematic review. J Gastroenterol Hepatol. 2012; 27:1561-1568.","DOI":"10.1111\/j.1440-1746.2012.07207.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wang Z, Sheng YY, Dong QZ, Qin LX. Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis. World J Gastroenterol. 2016; 22:3038-3051.","DOI":"10.3748\/wjg.v22.i10.3038"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Huang J, Wang X, Zhu Y, Wang Z, Li J, Xu D, Wang S, Li TE, Lu L. Specific prognostic factors in hepatitis B virus-related and non-hepatitis B virus-related intrahepatic cholangiocarcinoma after macroscopic curative resection. J Surg Oncol. 2019; 119:40-46.","DOI":"10.1002\/jso.25303"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Song Z, Lin S, Wu X, <i>et al<\/i>. Hepatitis B virus-related intrahepatic cholangiocarcinoma originates from hepatocytes. Hepatol Int. 2023; 17:1300-1317.","DOI":"10.1007\/s12072-023-10556-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Galle PR, Foerster F, Kudo M, Chan SL, Llovet JM, Qin S, Schelman WR, Chintharlapalli S, Abada PB, Sherman M, Zhu AX. Biology and significance of alpha-fetoprotein in hepatocellular carcinoma. Liver Int. 2019; 39:2214-2229.","DOI":"10.1111\/liv.14223"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Sun J, Zhao Y, Qin L, Li K, Zhao Y, Sun H, Zhang T, Zhang Y. Metabolomic Profiles for HBV Related Hepatocellular Carcinoma Including Alpha-Fetoproteins Positive and Negative Subtypes. Front Oncol. 2019; 9:1069.","DOI":"10.3389\/fonc.2019.01069"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yeo YH, Lee YT, Tseng HR, Zhu Y, You S, Agopian VG, Yang JD. Alpha-fetoprotein: Past, present, and future. Hepatol Commun. 2024; 8:e0422.","DOI":"10.1097\/HC9.0000000000000422"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ding Y, Chen Y, Zhang J, <i>et al<\/i>. Blood Biomarker-Based Predictive Indicator for Liver Metastasis in Alpha-Fetoprotein-Producing Gastric Cancer and Multi-Omics Tumor Microenvironment Insights. Ad<i>vs<\/i>ci (Weinh). 2025; 12:e03499.","DOI":"10.1002\/advs.202503499"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Li Y, Lin Y, Zhao L, Yang C, Wang B, Gao Z, Ye Y, Wang S, Shen Z. Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data. Transl Oncol. 2023; 36:101737.","DOI":"10.1016\/j.tranon.2023.101737"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. G\u00f6rgec B, Benedetti Cacciaguerra A, Lanari J, <i>et al<\/i>. Assessment of Textbook Outcome in Laparoscopic and Open Liver Surgery. JAMA Surg. 2021; 156:e212064.","DOI":"10.1001\/jamasurg.2021.2064"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Lin NC, Nitta H, Wakabayashi G. Laparoscopic major hepatectomy: a systematic literature review and comparison of 3 techniques. Ann Surg. 2013; 257:205-213.","DOI":"10.1097\/SLA.0b013e31827da7fe"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Bai S, Yang P, Liu J, Xue H, Xia Y, Liu F, Yang Z, Zhang L, Wu Y, Shen F, Wang K. Surgical Margin Affects the Long-Term Prognosis of Patients With Hepatocellular Carcinoma Undergoing Radical Hepatectomy Followed by Adjuvant TACE. Oncologist. 2023; 28:e633-e644.","DOI":"10.1093\/oncolo\/oyad088"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sha M, Jeong S, Xia Q. Antiviral therapy improves survival in patients with HBV infection and intrahepatic cholangiocarcinoma undergoing liver resection: Novel concerns. J Hepatol. 2018; 68:1315-1316.","DOI":"10.1016\/j.jhep.2018.01.039"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Xu X, Zhang HL, Liu QP, Sun SW, Zhang J, Zhu FP, Yang G, Yan X, Zhang YD, Liu XS. Radiomic analysis of contrast-enhanced CT predicts microvascular invasion and outcome in hepatocellular carcinoma. Journal of hepatology. 2019; 70:1133-1144.","DOI":"10.1016\/j.jhep.2019.02.023"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Zhou J, Sun H, Wang Z, <i>et al<\/i>. Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition). Liver cancer. 2023; 12:405-444.","DOI":"10.1159\/000530495"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Zhou YM, Yang JM, Li B, Yin ZF, Xu F, Wang B, Liu P, Li ZM. Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein. World J Gastroenterol. 2008; 14:2251-2254.","DOI":"10.3748\/wjg.14.2251"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Sheng R, Zhang Y, Wang H, Zhang W, Jin K, Sun W, Dai Y, Zhou J, Zeng M. A multi-center diagnostic system for intrahepatic mass-forming cholangiocarcinoma based on preoperative MRI and clinical features. Eur Radiol. 2024; 34:548-559.","DOI":"10.1007\/s00330-023-10002-w"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Xu YP, Dong ZN, Zhou YQ, Zhao YJ, Zhao Y, Wang F, Huang XY, Guo CY. Role of eIF3C Overexpression in Predicting Prognosis of Intrahepatic Cholangiocarcinoma. Digestive diseases and sciences. 2022; 67:559-568.","DOI":"10.1007\/s10620-021-06878-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Izquierdo-Sanchez L, Lamarca A, La Casta A, <i>et al<\/i>. Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry. Journal of hepatology. 2022; 76:1109-1121.","DOI":"10.1016\/j.jhep.2021.12.010"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Bagante F, Spolverato G, Merath K, <i>et al<\/i>. Intrahepatic cholangiocarcinoma tumor burden: A classification and regression tree model to define prognostic groups after resection. Surgery. 2019; 166:983-990.","DOI":"10.1016\/j.surg.2019.06.005"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology. 2014; 147:765-783.e764.","DOI":"10.1053\/j.gastro.2014.07.018"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Dhar D, Antonucci L, Nakagawa H, <i>et al<\/i>. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018; 33:1061-1077.e1066.","DOI":"10.1016\/j.ccell.2018.05.003"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Kojima K, Takata A, Vadnais C, <i>et al<\/i>. MicroRNA122 is a key regulator of \u03b1-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. Nat Commun. 2011; 2:338.","DOI":"10.1038\/ncomms1345"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Karayiannis P. Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread. Hepatol Int. 2017; 11:500-508.","DOI":"10.1007\/s12072-017-9829-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Nomoto K, Tsuneyama K, Cheng C, Takahashi H, Hori R, Murai Y, Takano Y. Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal\/stem-cell phenotype. Pathol Res Pract. 2006; 202:71-76.","DOI":"10.1016\/j.prp.2005.10.011"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S. Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Cancer Lett. 2010; 294:25-34.","DOI":"10.1016\/j.canlet.2010.01.019"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Takahashi H, Oyamada M, Fujimoto Y, Satoh MI, Hattori A, Dempo K, Mori M, Tanaka T, Watabe H, Masuda R, Yoshida M. Elevation of serum alpha-fetoprotein and proliferation of oval cells in the livers of LEC rats. Jpn J Cancer Res. 1988; 79:821-827.","DOI":"10.1111\/j.1349-7006.1988.tb00043.x"}],"container-title":["BioScience Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/20\/1\/20_2025.01327\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:59:26Z","timestamp":1772859566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bst\/20\/1\/20_2025.01327\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5582\/bst.2025.01327","relation":{},"ISSN":["1881-7815","1881-7823"],"issn-type":[{"value":"1881-7815","type":"print"},{"value":"1881-7823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"article-number":"2025.01327"}}