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Sakai T, Kuzukawa A, Yoshikawa K, Kishi Y, Kuwaki T, Ichikawa T. Changes in neutrophils and plasma G-CSF during operation and early postoperative period (in Japanese). J Jpn Soc Clin Anesth. 1996; 16:365-369.","DOI":"10.2199\/jjsca.16.365"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Tabuchi Y, Shinka S, Ishida H. The effects of anesthesia and surgery on count and function of neutrophils. J Anesth. 1989; 3:123-131.","DOI":"10.1007\/s0054090030123"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Yokota K, Nishihira T, Shineha R, Sayama J, Nitta Y, Kimura M, Mori S. Association between elevated plasma granulocyte colony-stimulating factor and the degree of surgical stress in patients undergoing gastrointestinal surgery. Surg Today. 1995; 25:579-584.","DOI":"10.1007\/BF00311429"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Iwasaka H, Kitano T, Miyakawa H, Unoshima M, Shinguu C, Matsumoto S, Noguchi T. 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