{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:20:07Z","timestamp":1778822407918,"version":"3.51.4"},"reference-count":19,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DD&amp;T"],"published-print":{"date-parts":[[2017]]},"DOI":"10.5582\/ddt.2017.01025","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T18:14:48Z","timestamp":1498328088000},"page":"161-164","source":"Crossref","is-referenced-by-count":11,"title":["Beta blocker and steroid therapy in the treatment of infantile hepatic hemangioendothelioma"],"prefix":"10.5582","volume":"11","author":[{"given":"Zeynep Canan","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Eski\u015fehir Osmangazi University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeter","family":"D\u00fczenli Kar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Eski\u015fehir Osmangazi University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurullah Cihan","family":"\u015e\u00f6hret","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Eski\u015fehir Osmangazi University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Kebap\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eski\u015fehir Osmangazi University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zcan","family":"B\u00f6r","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics, Eski\u015fehir Osmangazi University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Kim EH, Koh KN, Park M, Kim BE, Im HJ, Seo JJ. Clinical features of infantile hepatic hemangioendothelioma. Korean J Pediatr. 2011; 54:260-266.","DOI":"10.3345\/kjp.2011.54.6.260"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Isaacs H Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007; 42:1797-1803.","DOI":"10.1016\/j.jpedsurg.2007.07.047"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Pan FS, Xu M, Wang W, Zhou LY, Xie XY. Infantile hepatic hemangioendothelioma in comparison with hepatoblastoma in children: Clinical and ultrasound features. Hepat Mon. 2013; 13:e11103.","DOI":"10.5812\/hepatmon.11103"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Barnes CM, Huang S, Kaipainen A, Sanoudou D, Chen EJ, Eichler GS, Guo Y, Yu Y, Ingber DE, Mulliken JB, Beggs AH, Folkman J, Fishman SJ. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A. 2005; 102:19097-19102.","DOI":"10.1073\/pnas.0509579102"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Emre S, McKenna GJ. Liver tumors in children. Pediatr Transplant. 2004; 8:632-638.","DOI":"10.1111\/j.1399-3046.2004.00268.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ganguly R, Mukherjee A. Infantile hemangio-endothelioma: A case report and discussion. Pathol Res Pract. 2010; 206:53-58.","DOI":"10.1016\/j.prp.2009.01.017"},{"key":"7","unstructured":"7. Sevinir B, \u00d6zkan TB. Infantile hepatic hemangio-endothelioma: Clinical presentation and treatment. Turk J Gastroenterol. 2007; 18:182-187."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Moon SB, Kwon HJ, Park KW, Yun WJ, Jung SE. Clinical experience with infantile hepatic hemangioendothelioma. World J Surg. 2009; 33:597-602.","DOI":"10.1007\/s00268-008-9882-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ho J, Kendrick V, Dewey D, Pacaud D. New insight into the pathophysiology of severe hypothyroidism in an infant with multiple hepatic hemangiomas. J Pediatr Endocrinol Metab. 2005; 18:511-514.","DOI":"10.1515\/JPEM.2005.18.5.511"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, Fishman SJ, Larsen PR. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Eng J Med. 2000; 343:185-189.","DOI":"10.1056\/NEJM200007203430305"},{"key":"11","doi-asserted-by":"crossref","unstructured":"12. Dasgupta MK, Das S, Patra C, Sarkar S. Symptomatic Infantile Hepatic Hemangioendothelioma successfully treated with steroid. J Clin Neonatol. 2013; 2:187-189.","DOI":"10.4103\/2249-4847.123099"},{"key":"12","doi-asserted-by":"crossref","unstructured":"14. Mazereeuw-Hautier J, Hoeger PH, Benlahrech S, Ammour A, Broue P, Vial J, Ohanessian G, L\u00e9aut\u00e9-Labr\u00e8ze C, Labenne M, Vabres P, R\u00f6ssler J, Bodemer C. Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis. J Pediatr. 2010; 157:340-342.","DOI":"10.1016\/j.jpeds.2010.04.003"},{"key":"13","doi-asserted-by":"crossref","unstructured":"15. Kim TJ, Lee YS, Song YS, Park CK, Shim SI, Kang CS, Lee KY. Infantile hemangioendothelioma with elevated serum alpha fetoprotein: Report of 2 cases with immunohistochemical analysis. Hum Pathol. 2010; 41:763-767.","DOI":"10.1016\/j.humpath.2009.05.019"},{"key":"14","doi-asserted-by":"crossref","unstructured":"16. Mortele KJ, Vanzieleghem B, Mortele B, Benoit Y, Ros PR. Solitary hepatic infantile hemangioendothelioma: Dynamic gadolinium-enhanced MR imaging findings. Eur Radiol. 2002; 12:862-865.","DOI":"10.1007\/s003300101004"},{"key":"15","doi-asserted-by":"crossref","unstructured":"17. Blohm ME, Vesterling-Horner D, Calaminus G, Gobel U. Alpha 1-fe\u00actoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol. 1998; 15:135-42.","DOI":"10.3109\/08880019809167228"},{"key":"16","doi-asserted-by":"crossref","unstructured":"18. Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K. Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. Eur J Pediatr. 2010; 169:215-221.","DOI":"10.1007\/s00431-009-1009-x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"19. Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab. 2002; 87:4457-4461.","DOI":"10.1210\/jc.2002-020627"},{"key":"18","doi-asserted-by":"crossref","unstructured":"20. Schiestl C, Neuhaus K, Zoller S, Subotic U, Forster-Kuebler I, Michels R, Balmer C, Weibel L. Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas. Eur J Pediatr. 2011; 170:493-501.","DOI":"10.1007\/s00431-010-1324-2"},{"key":"19","doi-asserted-by":"crossref","unstructured":"21. Chim H, Armijo BS, Miller E, Gliniak C, Serret MA, Gosain AK. Propranolol induces regression of hemangioma cells through HIF-1a-mediated inhibition of VEGF-A. Ann Surg. 2012; 256:146-156.","DOI":"10.1097\/SLA.0b013e318254ce7a"}],"container-title":["Drug Discoveries &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/11\/3\/11_2017.01025\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T21:15:10Z","timestamp":1569532510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/11\/3\/11_2017.01025\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.5582\/ddt.2017.01025","relation":{},"ISSN":["1881-7831","1881-784X"],"issn-type":[{"value":"1881-7831","type":"print"},{"value":"1881-784X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}