{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:59:58Z","timestamp":1776272398659,"version":"3.50.1"},"reference-count":100,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DD&amp;T"],"published-print":{"date-parts":[[2017]]},"DOI":"10.5582\/ddt.2017.01030","type":"journal-article","created":{"date-parts":[[2017,9,3]],"date-time":"2017-09-03T22:07:43Z","timestamp":1504476463000},"page":"170-180","source":"Crossref","is-referenced-by-count":26,"title":["Higher incidence of nasopharyngeal carcinoma in some regions in the world confers for interplay between genetic factors and external stimuli"],"prefix":"10.5582","volume":"11","author":[{"given":"Nabanita","family":"Roy Chattopadhyay","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Visva-Bharati, Siksha Bhavana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyanki","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Visva-Bharati, Siksha Bhavana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koustav","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tathagata","family":"Choudhuri","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Visva-Bharati, Siksha Bhavana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Shanmugaratnam K, Chan SH, de The G, Goh JE, Khor TH, Simons MJ, Tye CY. Histopathology of nasopharyngeal carcinoma: Correlations with epidemiology, survival rates and other biological characteristics. Cancer. 1979; 44:1029-1044.","DOI":"10.1002\/1097-0142(197909)44:3<1029::AID-CNCR2820440335>3.0.CO;2-5"},{"key":"2","unstructured":"2. Chan JKC, Bray F, McCarron P, Foo W, Lee AWM, Yip T, Kuo TT, Pilch BZ, Wenig BM, Huang D, Lo KW, Zeng YX, Jia WH. Nasopharyngeal carcinoma. In: Who calssification of tumours: Pathology and genetics of head and neck tumours (Barnes L, Eveson JW, Reichart P, Sidransky D, Eds.). Lyon, France, IARC press, 2005; pp: 85-97."},{"key":"3","unstructured":"3. Chan JKC, Pilch BZ, Kuo TT, Wenig BM, Lee AWM. Tumours of the nasopharynx. In: Who calssification of tumours: Pathology and genetics of head and neck tumours (Barnes L, Eveson JW, Reichart P, Sidransky D, Eds.). Lyon, France, IARC press, 2005; pp: 81-125."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Zeng MS, Zeng YX. Pathogenesis and Etiology of Nasopharyngeal Carcinoma. In: Nasopharyngeal Cancer Multidisciplinary management (Lu JJ, Cooper JS, Lee AWM, eds.). Springer-Verlag, Berlin Heidelberg, 2010; pp: 9-25.","DOI":"10.1007\/978-3-540-92810-2_2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hildesheim A, Levine PH. Etiology of nasopharyngeal carcinoma: A review. Epidemiol Rev. 1993; 15:466-485.","DOI":"10.1093\/oxfordjournals.epirev.a036130"},{"key":"6","unstructured":"6. Li Z, Zong YS. Review of the histological classification of nasopharyngeal carcinoma. J Nasopharyng Carcinoma, 2014; 1:e15."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005; 365:2041-2054.","DOI":"10.1016\/S0140-6736(05)66698-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Chan ATC, Teo PML, Johnson PJ. Nasopharyngeal carcinoma. Ann Oncol. 2002; 13:1007-1015.","DOI":"10.1093\/annonc\/mdf179"},{"key":"9","unstructured":"9. Wei KR, Xu Y, Liu J, Zhang WJ, Liang ZH. Histopathological classification of nasopharyngeal carcinoma. Asian Pacific J Cancer Prev. 2011; 12:1141-1147."},{"key":"10","unstructured":"10. Paulino AC, Louis CU. Nasopharyngeal cancer. eMedicine Nov.17, 2016. www.emedicine.com\/ped\/topic1553.htm. (Tebbi CK, Windle ML, Bergstrom SK, Eds.) (accessed Dec.17, 2016)."},{"key":"11","unstructured":"11. Ruckenstein MJ. Nasopharyngeal carcinoma. In: Comprehensive Review of Otolaryngology (Ruckenstein MJ, ed.). W.B. Saunders, Philadelphia, 2004; pp: 197-198."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Brennan B. Nasopharyngeal carcinoma. Orphanet J Rare Dis. 2006; 1:23-27.","DOI":"10.1186\/1750-1172-1-23"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Pak MW, To KF, Leung SF, van Hasselt CA. In vivo diagnosis of persistent and recurrent nasopharyngeal carcinoma by contact endoscopy. Laryngoscope. 2002; 112:1459-1466.","DOI":"10.1097\/00005537-200208000-00025"},{"key":"14","unstructured":"14. Li JX, Lu TX, Huang Y, Han F. Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area. ScientificWorldJournal. 2012; 2012:719754."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang WH, Lin YC, Chen WC, Chen MF, Chen CC, Lee KF. Detection of mucosal recurrent nasopharyngeal carcinomas after radiotherapy with narrow-band imaging endoscopy. Int J Radiat Oncol Biol Phys. 2012; 83:1213-1219.","DOI":"10.1016\/j.ijrobp.2011.09.034"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ng SH, Chang JT, Ko SF, Wan YL, Tang LM, Chen WC. MRI in recurrent nasopharyngeal carcinoma. Neuroradiology. 1999; 41:855-862.","DOI":"10.1007\/s002340050857"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Tabuchi K, Nakayama M, Nishimura B, Hayashi K, Hara A. Early detection of nasopharyngeal carcinoma. Int J Otolaryngol. 2011; 2011:638058.","DOI":"10.1155\/2011\/638058"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, Ensley JF. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099. J Clin Oncol. 1998; 16:1310-1317.","DOI":"10.1200\/JCO.1998.16.4.1310"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Chan AT, Teo PM, Ngan RK, et al. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression free survival analysis of a phase III randomized trial. J Clin Oncol. 2002; 20:2038-2044.","DOI":"10.1200\/JCO.2002.08.149"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Wee J, Tan EH, Tai BC, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer\/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol. 2005; 23:6730-6738.","DOI":"10.1200\/JCO.2005.16.790"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Vermorken JB, Remenar E, van Herpen C, et al. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 2007; 357:1695-1704.","DOI":"10.1056\/NEJMoa071028"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lee AWM, Ma BBY, Ng WT, Chan ATC. Management of nasopharyngeal carcinoma: Current practice and future perspective. J Clin Oncol. 2015; 33:3356-3364.","DOI":"10.1200\/JCO.2015.60.9347"},{"key":"23","unstructured":"23. Spratt DE, Lee N. Current and emerging treatment options for nasopharyngeal carcinoma. Onco Targets Ther. 2012; 5:297-308."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Xu T, Tang J, Gu M, Liu L, Wei W, Yang H. Recurrent nasopharyngeal carcinoma: A clinical dilemma and challenge. Curr Oncol. 2013; 20:e406-e419.","DOI":"10.3747\/co.20.1456"},{"key":"25","unstructured":"25. American Cancer Society. What Are the Risk Factors for Nasopharyngeal Cancer? http:\/\/www.cancer.org\/cancer\/nasopharyngealcancer\/detailedguide\/nasopharyngeal-cancer-risk-factors (Accessed on Dec. 02, 2016)."},{"key":"26","unstructured":"26. Yu MC. Nasopharyngeal carcinoma: Epidemiology and dietary factors. IARC Sci Publ. 1991; 105:39-47."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Zheng YM, Tuppin P, Hubert A, Jeannel D, Pan YJ, Zeng Y, de Th\u00e9 G. Environmental and dietary risk factors for nasopharyngeal carcinoma: A case-control study in Zangwu County, Guangxi, China. Br J Cancer. 1994; 69:508-514.","DOI":"10.1038\/bjc.1994.92"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Cheng YJ, Hildesheim A, Hsu MM, Chen IH, Brinton LA, Levine PH, Chen CJ, Yang CS. Cigarette smoking, alcohol consumption and risk of nasopharyngeal carcinoma in Taiwan. Cancer Causes Control. 1999; 10:201-207.","DOI":"10.1023\/A:1008893109257"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Xu FH, Xiong D, Xu YF, et. al. An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. J Natl Cancer Inst. 2012; 104:1396-1410.","DOI":"10.1093\/jnci\/djs320"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Xie SH, Yu ITS, Tse LA, Mang OWK, Yue L. Sex difference in the incidence of nasopharyngeal carcinoma in Hong Kong 1983-2008: Suggestion of a potential protective role of oestrogen. Eur J Cancer. 2013; 49:150-155.","DOI":"10.1016\/j.ejca.2012.07.004"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Xiao G, Cao Y, Qiu X, Wang W, Wang Y. Influence of gender and age on the survival of patients with nasopharyngeal carcinoma. BMC Cancer. 2013; 13:226-233.","DOI":"10.1186\/1471-2407-13-226"},{"key":"32","unstructured":"32. Hirayama T. Descriptive and analytical epidemiology of nasopharyngeal cancer. In: Nasopharyngeal Carcinoma: Etiology and Control (de The G, Ito Y, eds.). IARC Scientific Pub, 1978; pp 167-169."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Chou J, Lin Y-C, Kim J, You L, Xu Z, He B, Jablons DM. Nasopharyngeal carcinoma \u2013 Review of the molecular mechanisms of tumorigenesis. Head Neck. 2008; 30:946-963.","DOI":"10.1002\/hed.20833"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Shah SM, Drage MG, Lichtman AH, Haddad RI. Metastatic human papillomavirus\u2013positive nasopharyngeal carcinoma with an unusual pattern of aggressive hematogenous spread. J Clin Oncol. 2012; 30:e321-e323.","DOI":"10.1200\/JCO.2012.42.3566"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Fedder M, Gonzalez MF. Nasopharyngeal carcinoma \u2013 Brief review. Am J Med. 1985; 79:365-369.","DOI":"10.1016\/0002-9343(85)90315-8"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. de The G. Epidemiology of the Epstein Barr virus and associated disease. In: Herpes Viruses (Riozman B, ed.). Plenum Press, New York, 1982; p. 25.","DOI":"10.1007\/978-1-4684-4163-5_2"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Yuan JM, Wang XL, Xiang YB, Gao YT, Ross RK, Yu MC. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer. 2000; 85:358-363.","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<358::AID-IJC11>3.0.CO;2-E"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Fong YY, Chan WC. Bacterial production of dimethyl nitrosamine in salted fish. Nature. 1973; 243:421-422.","DOI":"10.1038\/243421a0"},{"key":"39","unstructured":"39. Fong YY, Walsh EO. Carcinogenic nitrosamines in cantonese salt-dried fish. Lancet. 1971; 2:1032."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Yu MC, Nichols PW, Zou XN, Estes J, Henderson BE. Induction of malignant nasal cavity tumour in Wistar rats fed Chinese salted fish. Br J Cancer. 1989; 60:198-201.","DOI":"10.1038\/bjc.1989.250"},{"key":"41","unstructured":"41. Ho HC. Current knowledge of the epidemiology of nasopharyngeal carcinoma \u2013 A review. IARC Sci Publ. 1972; 2:357-366."},{"key":"42","unstructured":"42. Preston-Martin S. N-nitroso compounds as a cause of human cancer. IARC Sci Publ. 1987; 84:477-484."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Zou XN, Lu SH, Liu B. Volatile N-nitrosamines and their precursors in Chinese salted fish-a possible etological factor for NPC in china. Int J Cancer. 1994; 59:155-158.","DOI":"10.1002\/ijc.2910590202"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Shao YM, Poirier S, Ohshima H, Malaveille C, Zeng Y, de Th\u00e9 G, Bartsch H. Epstein-Barr virus activation in Raji cells by extracts of preserved food from high risk areas for nasopharyngeal carcinoma. Carcinogenesis. 1988; 9:1455-1457.","DOI":"10.1093\/carcin\/9.8.1455"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Poirier S, Bouvier G, Malaveille C, Ohshima H, Shao YM, Hubert A, Zeng Y, de Th\u00e9 G, Bartsch H. Volatile nitrosamine levels and genotoxicity of food samples from high-risk areas for nasopharyngeal carcinoma before and after nitrosation. Int J Cancer. 1989; 44:1088-1094.","DOI":"10.1002\/ijc.2910440625"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Chen CS, Pignatelli B, Malaveille C, Bouvier G, Shuker D, Hautefeuille A, Zhang RF, Bartsch H. Levels of direct-acting mutagens, total N-nitroso compounds in nitrosated fermented fish products, consumed in a high-risk area for gastric cancer in southern China. Mutat Res. 1992; 265:211-221.","DOI":"10.1016\/0027-5107(92)90050-C"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Poirier S, Ohishima H, de The G, Hubert A, Bourgade HC, Bartsch H. Volatile nitrosamine levels in common food from Tunisia, South China and Green land \u2013 high risk area for nasopharyngeal carcinoma. Int J Cancer. 1987; 39:293-296.","DOI":"10.1002\/ijc.2910390305"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Sarkar S, Nagabhushan M, Soman CS, Tricker AR, Bhide SV. Mutagenicity and carcinogenicity of smoke dried meat from Nagaland \u2013 A region of India prone to high incidence of nasopharyngeal cancer. Carcinogenesis. 1989; 10:733-736.","DOI":"10.1093\/carcin\/10.4.733"},{"key":"49","unstructured":"49. Chellang PK, Narain K, Das HK, Chetia M, Mahanta J. Risk factor for cancer of nasopharynx: A case control study from Nagaland, India. Natl Med J India. 2000; 13:6-8."},{"key":"50","unstructured":"50. Yu MC, Mo CC, Chong WX, Yeh FS, Henderson BE. Preserved foods and nasopharyngeal carcinoma: A case-control study in Guangxi, China. Cancer Res. 1988; 48:1954-1959."},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Yu MC, Huang TB, Henderson BE. Diet and nasopharyngeal carcinoma: A case-control study in Guangzhou, China. Int J Cancer. 1989; 43:1077-1082.","DOI":"10.1002\/ijc.2910430621"},{"key":"52","unstructured":"52. Turkoz FP, Celenkoglu G, Dogu GG, Kalender ME, Coskun U, Alkis N, Ozkan M, Turk HM, Arslan UY. Risk factors of nasopharyngeal carcinoma in Turkey \u2013 an epidemiological survey of the Anatolian Society of Medical Oncology. Asian Pac J Cancer Prev. 2011; 12:3017-3021."},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Cheng YJ, Hildesheim A, Hsu MM, Chen IH, Brinton LA, Levine PH, Chen CJ, Yang CJ. Cigarette smoking, alcohol consumption and risk of nasopharyngeal carcinoma in Taiwan. Cancer Causes Control. 1999; 10:201-207.","DOI":"10.1023\/A:1008893109257"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Cheung F, Chan O, Ng WT, Chan L, Lee A, Pang SW. The prognostic value of histological typing in nasopharyngeal carcinoma. Oral Oncol. 2012; 48:429-433.","DOI":"10.1016\/j.oraloncology.2011.11.017"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Lin JH, Jiang CQ, Ho SY, Zhang WS, Mai ZM, Xu L, Lo CM, Lam TH. Smoking and nasopharyngeal carcinoma mortality: A cohort study of 101,823 adults in Guangzhou, China. BMC Cancer. 2015; 15:906-912.","DOI":"10.1186\/s12885-015-1902-9"},{"key":"56","unstructured":"56. Kumar S, Zinyu R, Singh IKK, Medhi SB, Baruah T, Das B, Dutta LP. Studies on nasopharyngeal carcinoma with reference to the north eastern region of India. Ann Natl Acad Med Sci (India). 1996; 32:199-208."},{"key":"57","unstructured":"57. Clifford P, Bulbrook RD. Environmental studies in African males in nasopharyngeal carcinoma. Lancet. 1967; 1:1228."},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Yu MC, Garabrant DH, Huang TB, Henderson BE. Occupational and other non-dietary risk factors for nasopharyngeal carcinoma in Guangzhou, China. Int J Cancer. 1990; 45:1033-1039.","DOI":"10.1002\/ijc.2910450609"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Lin TM, Chen KP, Lin CC, Hsu MM, Tu SM, Chiang TC, Jung PF, Hirayama T. Retrospectives study on nasopharyngeal carcinoma. J Natl Cancer Inst. 1973; 51:1403-1408.","DOI":"10.1093\/jnci\/51.5.1403"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Shi Y, Peng SL, Yang LF, Chen X, Tao YG, Cao Y. Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis. Chin J Cancer. 2016; 35:16-24.","DOI":"10.1186\/s40880-016-0079-1"},{"key":"61","unstructured":"61. International Agency for Research on Cancer. Epstein Barr virus and Kaposi&apos;s sarcoma, herpes virus\/human herpes virus. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, IARC press, Lyon, France, 1997."},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Epstein MA, Achang BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt&apos;s lumphoma. Lancet. 1964; 1:702.","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Klein E, Kis LL, Klein G. Epstein-Barr virus infection in humans: From harmless to life endangering virus-lymphocyte interactions. Oncogene. 2007; 26:1297-1305.","DOI":"10.1038\/sj.onc.1210240"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Thompson MP, Kurzrock R. Epstein-Barr virus and cancer. Clin Cancer Res. 2004; 10:803-821.","DOI":"10.1158\/1078-0432.CCR-0670-3"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Young LS, Yap LF, Murray PG. Epstein-Barr virus: More than 50 years old and still providing surprises. Nat Rev Cancer. 2016; 16:789-802.","DOI":"10.1038\/nrc.2016.92"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Demonstration of the Burkitt&apos;s lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci U S A. 2004; 101:239-244.","DOI":"10.1073\/pnas.2237267100"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Halder S, Murakami M, Verma SC, Kumar P, Yi F, Robertson ES. Early events associated with infection of Epstein-Barr virus infection of primary B-cells. PLoS ONE. 2009; 4:e7214-e7229.","DOI":"10.1371\/journal.pone.0007214"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Houldcroft CJ, Kellam P. Host genetics of Epstein-Barr virus infection, latency and disease. Rev Med Virol. 2015; 25:71-84.","DOI":"10.1002\/rmv.1816"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Cohen JI, Wang F, Mannick J, Kieff E. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc Nati Acad Sci U S A. 1989; 86:9558-9562.","DOI":"10.1073\/pnas.86.23.9558"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Hammerschmidt W, Sugden B. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B-lymphocytes. Nature. 1989; 340:393-397.","DOI":"10.1038\/340393a0"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Alfieri C, Birkenbach M, Kieff E. Early events in Epstein-Barr virus infection of human B lymphocytes. Virology. 1991; 181:595-608.","DOI":"10.1016\/0042-6822(91)90893-G"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72. Zheng X, Yan L, Nilsson B, Eklund G, Drettner B. Epstein-Barr virus infection, salted fish and nasopharyngeal carcinoma in southern China. Acta Oncol. 1994; 33:867-872.","DOI":"10.3109\/02841869409098448"},{"key":"73","unstructured":"73. Hildesheim A, West S, DeVeyra E, DeGuzman MF, Jurado A, Jones C, Imai J, Hinuma Y. Herbal medicine use, Epstein Barr virus, and risk of nasopharyngeal carcinoma. Cancer Res. 1992; 52:3048-3051."},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. de The G, Sohier R, Ho JHC, Freund R. Nasopharyngeal carcinoma. IV. Evolution of complement fixing antibodies during the course of the disease. Int J Cancer. 1973; 12:368-377.","DOI":"10.1002\/ijc.2910120208"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Zhang HY, Qo G, Deng ZW, Yao TH, Glaser R. Epstein Barr virus DNA in nasopharyngeal biopsies. Virus Res. 1989; 12:53-59.","DOI":"10.1016\/0168-1702(89)90053-1"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Yap YY, Hassan S, Chan M, Choo PK, Ravichandran M.Epstein-Barr virus DNA detection in the diagnosis of nasopharyngeal carcinoma. Otolaryngol Head Neck Surg. 2007; 136:986-991.","DOI":"10.1016\/j.otohns.2006.11.027"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Jia Y, Wang Y, Chao Y, Jing Y, Sun Z, Luo B. Sequence analysis of the Epstein-Barr virus (EBV) BRLF1 gene in nasopharyngeal and gastric carcinomas. Virol J. 2010; 7:341-348.","DOI":"10.1186\/1743-422X-7-341"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Grunewald V, Bonnet M, Boutin S, et al. Amino-acid change in the Epstein-Barr-virus ZEBRA protein in undifferentiated nasopharyngeal carcinomas from Europe and North Africa. Int J Cancer. 1998; 75:497-503.","DOI":"10.1002\/(SICI)1097-0215(19980209)75:4<497::AID-IJC2>3.0.CO;2-O"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. See HS, Yap YY, Yip WK, Seow HF. Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia. World J Surg Oncol. 2008; 6:18-27.","DOI":"10.1186\/1477-7819-6-18"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Jing YZ, Wang Y, Jia YP, Luo B. Polymorphisms of Epstein-Barr virus BHRF1 gene, a homologue of bcl-2. Chin J Cancer. 2010; 29:1000-1005.","DOI":"10.5732\/cjc.010.10241"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Wang Y, Zhang X, Chao Y, Jia Y, Xing X, Luo B. New Variations of Epstein-Barr virus-encoded small RNA genes in nasopharyngeal carcinomas, gastric carcinomas, and healthy donors in northern China. J Med Virol. 2010; 82:829-836.","DOI":"10.1002\/jmv.21714"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Hildesheim A, Anderson LM, Chen CJ, Cheng YJ, Brinton LA, Daly AK, Reed CD, Chen IH, Caporaso NE, Hsu MM, Chen JY, Idle JR, Hoover RN, Yang CS, Chhabra SK. CYP2 E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst. 1997; 89:1207-1212.","DOI":"10.1093\/jnci\/89.16.1207"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Kongruttanachok N, Sukdikul S, Setavarin S, Kerekhjanarong V, Supiyaphun P, Voravud N, Poovorawan Y, Mutirangura A. Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: A corrective study. BMC Cancer. 2001; 1:4-8.","DOI":"10.1186\/1471-2407-1-4"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Simons MJ, Wee, GB, Day NE, Morris PJ, Shanmugaratnam K, de The G. Immunogenetic aspects of nasopharyngeal carcinoma: I. Differences in HLA antigen profiles between patients and control groups. Int J Cancer. 1974; 13:122-134.","DOI":"10.1002\/ijc.2910130114"},{"key":"85","unstructured":"85. Chan SH. Immunogenetics of nasopharyngeal carcinoma \u2013 Position in 1980. Ann Acad Med Singapore. 1980; 9:296-299."},{"key":"86","unstructured":"86. Simons MJ, Shanmugaratnam K (eds.). The Biology of Nasopharyngeal Carcinoma: UICC Technical Report Series 17, 1982."},{"key":"87","unstructured":"87. Chan SH. Etiology of nasopharyngeal carcinoma. Ann Acad Med Singapore. 1990; 19:201-207."},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006; 15:1765-1777.","DOI":"10.1158\/1055-9965.EPI-06-0353"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Effert P, McCoy R, Abdel-Hamid M, Flynn K, Zhang Q, Busson P, Tursz T, Liu E, Raab-Traub N. Alterations of the p53 gene in nasopharyngeal carcinoma. J Virol. 1992; 66:3768-3775.","DOI":"10.1128\/JVI.66.6.3768-3775.1992"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Sahu SK, Chakrabarti S, Roy SD, et al. Association of p53 codon72 Arg4Pro polymorphism with susceptibility to nasopharyngeal carcinoma: Evidence from a case-control study and meta-analysis. Oncogenesis. 2016; 5:e225.","DOI":"10.1038\/oncsis.2016.31"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Tulalamba W, Janvilisri T. Nasopharyngeal carcinoma signaling pathway: An update on molecular biomarkers. Int J Cell Biol. 2012; 2012:594681.","DOI":"10.1155\/2012\/594681"},{"key":"92","unstructured":"92. Xie Y, Wu Y, Zhou X, Yao M, Ning S, Wei Z. Association of polymorphisms hOgg1 rs1052133 and hMUTYh rs3219472 with risk of nasopharyngeal carcinoma in a chinese population. Onco Targets Ther. 2016; 9:755-760."},{"key":"93","unstructured":"93. Simons MJ, Chao SM, Wee GD, Shanmugaratnam K, Goh EH, Ho JHC, Chao JCW, Dharmalingam S, Prasad U, Betuel H, Day NE, de The G. Nasopharyngeal carcinoma and histocompatibility antigens. IARC Sci Publ. 1978; 20:271-282."},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Chan SH, Day NE, Kunaratnam N, Chia KB, Simons MJ. HLA and nasopharyngeal carcinoma in Chinese \u2013 a further study. Int J Cancer. 1983; 32:171-176.","DOI":"10.1002\/ijc.2910320206"},{"key":"95","unstructured":"95. Burt RD, Vaughan TL, McKnight B, Davis S, Beckmann AM, Smith AG, Nisperos B, Swanson GM, Berwick M. Associations between human leukocyte antigen type and nasopharyngeal carcinoma in Caucasians in the United States. Cancer Epidemiol Biomarkers Prev. 1996; 5:879-887."},{"key":"96","unstructured":"96. Simons MJ, Wee GB, Chan SH, Shanmugaratnam K, Day NE, de-The G. Immunogenetic aspects of nasopharyngeal carcinoma (NPC) III. HL-a type as a genetic marker of NPC predisposition to test the hypothesis that Epstein-Barr virus is an etiological factor in NPC. IARC Sci Publ. 1975; 11:249-258."},{"key":"97","doi-asserted-by":"crossref","unstructured":"97. Yang H, Yu K, Zhang R, Li J, Wei X, Zhang Y, Zhang C, Xiao F, Zhao D, Lin X, Wu H, Yang X. The HLA-DRB1 allele polymorphisms and nasopharyngeal carcinoma. Tumour Biol. 2016. 37:7119-7128.","DOI":"10.1007\/s13277-016-5051-9"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Lakhanpal M, Singh LC, Rahman T, Sharma J, Singh MM, Kataki AC, Verma S, Chauhan PS, Singh YM, Wajid S, Kapur S, Saxena S. Contribution of susceptibility locus at HLA class I region and environmental factors to occurrence of nasopharyngeal cancer in Northeast India. Tumour Biol. 2015; 36:3061-3073.","DOI":"10.1007\/s13277-014-2942-5"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Gervasi PG, Longo V, Naidi F, Panattoni G, Ursino FX. Xenobiotic metabolizing enzymes in human respiratory nasal mucosa. Biochem Pharmacol. 1991; 41:177-184.","DOI":"10.1016\/0006-2952(91)90474-J"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Poulsen HE, Loft S, Wassermann K. Cancer risk related to genetic polymorphisms in carcinogen metabolism and DNA repair. Pharmacol Toxicol. 1993; 72(Suppl 1):93-103.","DOI":"10.1111\/j.1600-0773.1993.tb01676.x"}],"container-title":["Drug Discoveries &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/11\/4\/11_2017.01030\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:01:44Z","timestamp":1602892904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/11\/4\/11_2017.01030\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":100,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.5582\/ddt.2017.01030","relation":{},"ISSN":["1881-7831","1881-784X"],"issn-type":[{"value":"1881-7831","type":"print"},{"value":"1881-784X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}