{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:58:03Z","timestamp":1776286683873,"version":"3.50.1"},"reference-count":32,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DD&amp;T"],"published-print":{"date-parts":[[2020,10,31]]},"DOI":"10.5582\/ddt.2020.03071","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T22:05:59Z","timestamp":1603922759000},"page":"243-248","source":"Crossref","is-referenced-by-count":4,"title":["The &lt;i&gt;in vitro&lt;\/i&gt; and &lt;i&gt;in vivo&lt;\/i&gt; anti-virulence activities of &lt;i&gt;Cinnamomum bejolghota&lt;\/i&gt; by inhibiting type three secretion system effector proteins of Salmonella"],"prefix":"10.5582","volume":"14","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongrong","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015; 14:111-129.","DOI":"10.1038\/nrd4510"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Thabit AK, Crandon JL, Nicolau DP. Antimicrobial resistance: impact on clinical and economic outcomes and the need for new antimicrobials. Expert Opin Pharmacother. 2015; 16:159-177.","DOI":"10.1517\/14656566.2015.993381"},{"key":"3","unstructured":"3. Muhlen S, Dersch P. Anti-virulence strategies to target bacterial infections. Curr Top Microbiol Immunol. 2016; 398:147-183."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lewis K, Ausubel FM. Prospects for plant-derived antibacterials. Nat Biotechnol. 2006; 24:1504-1507.","DOI":"10.1038\/nbt1206-1504"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Dickey SW, Cheung GYC, Otto M. Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017; 16:457-471.","DOI":"10.1038\/nrd.2017.23"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Silva LN, Zimmer KR, Macedo AJ, Trentin DS. Plant natural products targeting bacterial virulence factors. Chem Rev. 2016; 116:9162-9236.","DOI":"10.1021\/acs.chemrev.6b00184"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wright GD. Opportunities for natural products in 21(st) century antibiotic discovery. Nat Prod Rep. 2017; 34:694-701.","DOI":"10.1039\/C7NP00019G"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. DeFilipps RA, Krupnick GA. The medicinal plants of Myanmar. PhytoKeys. 2018; 102:1-341.","DOI":"10.3897\/phytokeys.102.24380"},{"key":"9","unstructured":"9. Gogoi B, Kakoti BB, Sharma N, Borah S. Pharmacognostic and preliminary phytochemical evaluation of <i>Cinnamomum bejolghota<\/i> (Buch.-Ham.) sweet bark. Indian J Nat Prod Resour 2016; 7:59-64."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Gogoi B, Kakoti BB, Borah S, Borah NS. Antihyperglycemic and <i>in vivo<\/i> antioxidative activity evaluation of <i>Cinnamomum bejolghota<\/i> (Buch.-Ham.) in streptozotocin induced diabetic rats: an ethnomedicinal plant in Assam. Asian Pac J Trop Med. 2014; 7S1:S427-434.","DOI":"10.1016\/S1995-7645(14)60270-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Li T, Zhang D, Oo TN, San MM, Mon AM, Hein PP, Wang Y, Lu C, Yang X. Investigation on the antibacterial and anti-T3SS activity of traditional Myanmar medicinal plants. Evid Based Complement Alternat Med. 2018; 2018:2812908.","DOI":"10.1155\/2018\/2812908"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Lee S, Gim H, Shim JH, Jung Kim H, Lee JR, Kim SC, Kwon YK, Ha KT, So I, Kim BJ. The traditional herbal medicine, Ge-Gen-Tang, inhibits pacemaker potentials by nitric oxide\/cGMP dependent ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from mouse small intestine. J Ethnopharmacol. 2015; 170:201-209.","DOI":"10.1016\/j.jep.2015.05.025"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Sujarwo W, Keim AP, Savo V, Guarrera PM, Caneva G. Ethnobotanical study of Loloh: Traditional herbal drinks from Bali (Indonesia). J Ethnopharmacol. 2015; 169:34-48.","DOI":"10.1016\/j.jep.2015.03.079"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Muhammad JS, Zaidi SF, Shaharyar S, Refaat A, Usmanghani K, Saiki I, Sugiyama T. Anti-inflammatory effect of cinnamaldehyde in <i>Helicobacter pylori<\/i> induced gastric inflammation. Biol Pharm Bull. 2015; 38:109-115.","DOI":"10.1248\/bpb.b14-00609"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Eswaran MB, Surendran S, Vijayakumar M, Ojha SK, Rawat AK, Rao Ch V. Gastroprotective activity of <i>Cinnamomum tamala<\/i> leaves on experimental gastric ulcers in rats. J Ethnopharmacol. 2010; 128:537-540.","DOI":"10.1016\/j.jep.2010.01.036"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Li J, Lv C, Sun W, Li Z, Han X, Li Y, Shen Y. Cytosporone B, an inhibitor of the type III secretion system of <i>Salmonella enterica<\/i> serovar Typhimurium. Antimicrob Agents Chemother. 2013; 57:2191-2198.","DOI":"10.1128\/AAC.02421-12"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hudson DL, Layton AN, Field TR, Bowen AJ, Wolf-Watz H, Elofsson M, Stevens MP, Galyov EE. Inhibition of type III secretion in <i>Salmonella enterica<\/i> serovar Typhimurium by small-molecule inhibitors. Antimicrob Agents Chemother. 2007; 51:2631-26355.","DOI":"10.1128\/AAC.01492-06"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Negrea A, Bjur E, Ygberg SE, Elofsson M, Wolf-Watz H, Rhen M. Salicylidene acylhydrazides that affect type III protein secretion in <i>Salmonella enterica<\/i> serovar Typhimurium. Antimicrob Agents Chemother. 2007; 51:2867-2876.","DOI":"10.1128\/AAC.00223-07"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kaiser P, Diard M, Stecher B, Hardt WD. The streptomycin mouse model for <i>Salmonella diarrhea<\/i>: functional analysis of the microbiota, the pathogen&apos;s virulence factors, and the host&apos;s mucosal immune response. Immunol Rev. 2012; 245:56-83.","DOI":"10.1111\/j.1600-065X.2011.01070.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hapfelmeier S, Hardt WD. A mouse model for <i>S.<\/i> Typhimurium-induced enterocolitis. Trends Microbiol. 2005; 13:497-503.","DOI":"10.1016\/j.tim.2005.08.008"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Tsolis RM, Xavier MN, Santos RL, Baumler AJ. How to become a top model: impact of animal experimentation on human salmonella disease research. Infect Immun. 2011; 79:1806-1814.","DOI":"10.1128\/IAI.01369-10"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Greenfield EA. Harvesting tissue from immunized mice, rats, and hamsters. Cold Spring Harb Protoc. 2017; 2017:pdb prot100362.","DOI":"10.1101\/pdb.prot100362"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Cardiff RD, Miller CH, Munn RJ. Mouse tissue fixation. Cold Spring Harb Protoc. 2014; 2014.","DOI":"10.1101\/pdb.prot073403"},{"key":"24","unstructured":"24. Robert D Cardiff 1 , Claramae H Miller 1 , Robert J. Munn Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb Protoc. 2014; 2014:655-658."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Prabst K, Engelhardt H, Ringgeler S, Hubner H. Basic colorimetric proliferation assays: MTT, WST, and Resazurin. Methods Mol Biol. 2017; 1601:1-17.","DOI":"10.1007\/978-1-4939-6960-9_1"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Liu Y, Zhang Y, Zhou Y, Wang T, Deng X, Chu X, Zhou T. Cinnamaldehyde inhibits type three secretion system in <i>Salmonella enterica<\/i> serovar Typhimurium by affecting the expression of key effector proteins. Vet Microbiol. 2019; 239:108463.","DOI":"10.1016\/j.vetmic.2019.108463"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Lv QH, Li SF, Wei HL, Wen ZM, Wang YL, Tang TZ, Wang JF, Xia LN, Deng XM. Identification of the natural product paeonol derived from peony bark as an inhibitor of the <i>Salmonella enterica<\/i> serovar Typhimurium type III secretion system. Appl Microbiol Biot. 2020; 104:1673-1682.","DOI":"10.1007\/s00253-019-10290-7"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Guo ZX, Li XL, Li JF, Yang XF, Zhou Y, Lu CH, Shen YM. Licoflavonol is an inhibitor of the type three secretion system of <i>Salmonella enterica<\/i> serovar Typhimurium. Biochem Bioph Res Co. 2016; 477:998-1004.","DOI":"10.1016\/j.bbrc.2016.07.018"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Zhang Y, Liu Y, Qiu JZ, Luo ZQ, Deng XM. The herbal compound thymol protects mice from lethal infection by <i>Salmonella Typhimurium<\/i>. Front Microbiol. 2018; 9:1022.","DOI":"10.3389\/fmicb.2018.01022"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Tsou LK, Yount JS, Hang HC. Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells. Bioorgan Med Chem. 2017; 25:2883-2887.","DOI":"10.1016\/j.bmc.2017.03.023"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Baruah A, Nath SC. Taxonomic status and composition of stem bark oil of a variant of <i>Cinnamomum bejolghota<\/i> (Lauraceae) from Northeast India. Nord J Bot. 2001; 21:571-576.","DOI":"10.1111\/j.1756-1051.2001.tb00812.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Patil M, Choudhari AS, Pandita S, Islam MA, Raina P, Kaul-Ghanekar R. Cinnamaldehyde, cinnamic acid, and cinnamyl alcohol, the bioactives of <i>Cinnamomum cassia<\/i> exhibit HDAC8 inhibitory activity: an <i>in vitro<\/i> and <i>in silico<\/i> study. Pharmacogn Mag. 2017; 13:S645-S651.","DOI":"10.4103\/pm.pm_389_16"}],"container-title":["Drug Discoveries &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/14\/5\/14_2020.03071\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T03:50:49Z","timestamp":1604721049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/14\/5\/14_2020.03071\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,31]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.5582\/ddt.2020.03071","relation":{},"ISSN":["1881-7831","1881-784X"],"issn-type":[{"value":"1881-7831","type":"print"},{"value":"1881-784X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,31]]}}}