{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:00:32Z","timestamp":1789563632108,"version":"build-2803163510"},"reference-count":23,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DD&amp;T"],"published-print":{"date-parts":[[2024,12,31]]},"DOI":"10.5582\/ddt.2024.01080","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T22:11:35Z","timestamp":1733868695000},"page":"368-374","source":"Crossref","is-referenced-by-count":12,"title":["Baricitinib-loaded EVs promote alopecia areata mouse hair regrowth by reducing JAK-STAT-mediated inflammation and promoting hair follicle regeneration"],"prefix":"10.5582","volume":"18","author":[{"given":"Haowen","family":"Tang","sequence":"first","affiliation":[{"name":"Faculty of Hepato-Pancreato-Biliary Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Wang","sequence":"additional","affiliation":[{"name":"The 55th retirement of Haidian district affiliated to Beijing Garrison, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine, Nankai University, Tianjin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of clinical medicine, China Medical University, Shenyang, Liaoning, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Hepato-Pancreato-Biliary Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol. 2021; 61:403-423.","DOI":"10.1007\/s12016-021-08883-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Vano-Galvan S, Figueras-Nart I, Artime E, Diaz-Cerezo S, Nunez M, Iglesias C, Artes M, Huete T. Epidemiological, clinical and economic burden of alopecia areata in Spain: a real-world retrospective study. The PETALO study. Eur J Dermatol. 2024; 34:163-175.","DOI":"10.1684\/ejd.2024.4654"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, Shapiro J. Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol. 2018; 78:1-12.","DOI":"10.1016\/j.jaad.2017.04.1141"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Fung S, Shirley M. Baricitinib: A review in severe alopecia areata. Am J Clin Dermatol. 2023; 24:661-668.","DOI":"10.1007\/s40257-023-00799-z"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Wang EHC, Sallee BN, Tejeda CI, Christiano AM. JAK inhibitors for treatment of alopecia areata. J Invest Dermatol. 2018; 138:1911-1916.","DOI":"10.1016\/j.jid.2018.05.027"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kincaid CM, Arnold JD, Mesinkovska NA. Baricitinib as the first systemic treatment for severe alopecia areata. Expert Rev Clin Immunol. 2023, 19:565-573.","DOI":"10.1080\/1744666X.2023.2200166"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Guan R, Lin Y, Zhang C, Wang Z, Wu Z, Liu X, Chen X, Piao Y. Comparative efficacy and safety of systemic steroids, oral JAK inhibitors and contact immunotherapy in the treatment of severe alopecia areata: a systematic review and network meta-analysis. Arch Dermatol Res. 2024; 316:483.","DOI":"10.1007\/s00403-024-03177-9"},{"key":"8","unstructured":"8. Zhang Y, Wang F, Li X, Zhao Y, Zhang J, Zhao W, Zhou C. Oral abrocitinib for treatment of refractory alopecia areata: A retrospective study. J Am Acad Dermatol. 2024:S0190-9622(24)02876-7."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. King B, Ohyama M, Kwon O,<i> et al<\/i>. Two phase 3 trials of baricitinib for alopecia areata. N Engl J Med. 2022; 386:1687-1699.","DOI":"10.1056\/NEJMoa2110343"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. King B, Ko J, Kwon O, Vano-Galvan S, Piraccini BM, Dutronc Y, Yu G, Liu C, Somani N, Ball S, Mesinkovska NA. Baricitinib withdrawal and retreatment in patients with severe alopecia areata: The BRAVE-AA1 randomized clinical trial. JAMA Dermatol. 2024, 160:1075-1081.","DOI":"10.1001\/jamadermatol.2024.2734"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Guo HW, Ye ZM, Chen SQ, McElwee KJ. Innovative strategies for the discovery of new drugs against alopecia areata: taking aim at the immune system. Expert Opin Drug Discov. 2024; 19:1321-1338.","DOI":"10.1080\/17460441.2024.2409660"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Bian X, Li B, Tang H, Li Q, Hu W, Wei Q, Ma K, Yang Y, Li H, Fu X, Zhang C. Extracellular vesicles derived from fibroblasts induced with or without high glucose exert opposite effects on wound healing and angiogenesis. Front Surg. 2022; 9:1065172.","DOI":"10.3389\/fsurg.2022.1065172"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Golchin A, Shams F, Basiri A, Ranjbarvan P, Kiani S, Sarkhosh-Inanlou R, Ardeshirylajimi A, Gholizadeh-Ghaleh Aziz S, Sadigh S, Rasmi Y. Combination therapy of stem cell-derived exosomes and biomaterials in the wound healing. Stem Cell Rev Rep. 2022; 18:1892-1911.","DOI":"10.1007\/s12015-021-10309-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Elsharkasy OM, Nordin JZ, Hagey DW, de Jong OG, Schiffelers RM, Andaloussi SE, Vader P. Extracellular vesicles as drug delivery systems: Why and how? Adv Drug Deliv Rev. 2020; 159:332-343.","DOI":"10.1016\/j.addr.2020.04.004"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Meng W, He C, Hao Y, Wang L, Li L, Zhu G. Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source. Drug Deliv. 2020; 27:585-598.","DOI":"10.1080\/10717544.2020.1748758"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Zhu Q, Ling X, Yang Y, Zhang J, Li Q, Niu X, Hu G, Chen B, Li H, Wang Y, Deng Z. Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy. Adv Sci (Weinh). 2019; 6:1801899.","DOI":"10.1002\/advs.201801899"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Kim G, Lee Y, Ha J, Han S, Lee M. Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation. J Control Release. 2021; 330:684-695.","DOI":"10.1016\/j.jconrel.2020.12.053"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Cao Y, Lu S, Tang H. miR-141-3p-loaded extracellular vesicles ameliorate intrahepatic bile duct stone disease by decreasing MUC5AC expression <i>via<\/i> the MAPK pathway. Intractable Rare Dis Res. 2024.","DOI":"10.5582\/irdr.2024.01051"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Gilhar A, Kam Y, Assy B, Kalish RS. Alopecia areata induced in C3H\/HeJ mice by interferon-gamma: evidence for loss of immune privilege. J Invest Dermatol. 2005; 124:288-289.","DOI":"10.1111\/j.0022-202X.2004.23580.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Chen L, Fan B, Gu H, Yang L, Li X. Effects of baicalin on alopecia and the associated mechanism. Biomed Res Int. 2022; 2022:3139123.","DOI":"10.1155\/2022\/3139123"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mohammadi-Meyabadi R, Beirampour N, Garros N, Alvarado HL, Limon D, Silva-Abreu M, Calpena AC, Mallandrich M. Assessing the solubility of baricitinib and drug uptake in different tissues using absorption and fluorescence spectroscopies. Pharmaceutics. 2022; 14:2714.","DOI":"10.3390\/pharmaceutics14122714"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wang C, Li N, Li Y, Hou S, Zhang W, Meng Z, Wang S, Jia Q, Tan J, Wang R, Zhang R. Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy\/internal irradiation combination therapy. J Nanobiotechnology. 2022; 20:247.","DOI":"10.1186\/s12951-022-01462-1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lee YJ, Park SH, Park HR, Lee Y, Kang H, Kim JE. Mesenchymal stem cells antagonize IFN-induced proinflammatory changes and growth inhibition effects <i>via<\/i> Wnt\/beta-catenin and JAK\/STAT pathway in human outer root sheath cells and hair follicles. Int J Mol Sci. 2021; 22:4581.","DOI":"10.3390\/ijms22094581"}],"container-title":["Drug Discoveries &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/18\/6\/18_2024.01080\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:24:54Z","timestamp":1737174294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/18\/6\/18_2024.01080\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.5582\/ddt.2024.01080","relation":{},"ISSN":["1881-7831","1881-784X"],"issn-type":[{"value":"1881-7831","type":"print"},{"value":"1881-784X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]},"article-number":"2024.01080"}}