{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:11:35Z","timestamp":1772928695588,"version":"3.50.1"},"reference-count":60,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DD&amp;T"],"published-print":{"date-parts":[[2026,2,28]]},"DOI":"10.5582\/ddt.2025.01120","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T22:09:23Z","timestamp":1770934163000},"page":"42-55","source":"Crossref","is-referenced-by-count":0,"title":["Xuefu Zhuyu Capsule alleviates depression in post-stroke depression model rats &lt;i&gt;via&lt;\/i&gt; modulation of the gut microbiota\u2013gut\u2013brain axis"],"prefix":"10.5582","volume":"20","author":[{"given":"Bowen","family":"Jin","sequence":"first","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejin","family":"Fan","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."},{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China."},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengwei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization, Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China."},{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China."},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Zhou H, Wei YJ, Xie GY. Research progress on post-stroke depression. Exp Neurol. 2024; 373:114660.","DOI":"10.1016\/j.expneurol.2023.114660"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Chen J, Wu Y, Chen Z, Yi B, Zhang L, Yin C, Feng H. High incidence of stroke in COVID-19 patients. Aging (Albany NY). 2020; 12:22390-22398.","DOI":"10.18632\/aging.104092"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hackett ML, Yapa C, Parag V, Anderson CS. Frequency of depression after stroke: a systematic review of observational studies. Stroke. 2005; 36:1330-1340.","DOI":"10.1161\/01.STR.0000165928.19135.35"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ayerbe L, Ayis S, Crichton S, Wolfe CD, Rudd AG. The natural history of depression up to 15 years after stroke: the South London Stroke Register. Stroke. 2013; 44:1105-1110.","DOI":"10.1161\/STROKEAHA.111.679340"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. De Ryck A, Brouns R, Geurden M, Elseviers M, De Deyn PP, Engelborghs S. Risk factors for poststroke depression: Identification of inconsistencies based on a systematic review. J Geriatr Psychiatry Neurol. 2014; 27:147-158.","DOI":"10.1177\/0891988714527514"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Medeiros GC, Roy D, Kontos N, Beach SR. Post-stroke depression: A 2020 updated review. Gen Hosp Psychiatry. 2020; 66:70-80.","DOI":"10.1016\/j.genhosppsych.2020.06.011"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Paolucci S. Advances in antidepressants for treating post-stroke depression. Expert Opin Pharmacother. 2017; 18:1011-1017.","DOI":"10.1080\/14656566.2017.1334765"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dinan TG, Cryan JF. Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology. Psychoneuroendocrinology. 2012; 37:1369-1378.","DOI":"10.1016\/j.psyneuen.2012.03.007"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Elangovan A, Dahiya B, Kirola L, <i>et al.<\/i> Does gut brain axis has an impact on Parkinson&apos;s disease (PD)? Ageing Res Rev. 2024; 94:102171.","DOI":"10.1016\/j.arr.2023.102171"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Abdellatif AM, Sarvetnick NE. Current understanding of the role of gut dysbiosis in type 1 diabetes. J Diabetes. 2019; 11:632-644.","DOI":"10.1111\/1753-0407.12915"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Morais LH, Schreiber HLt, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021; 19:241-255.","DOI":"10.1038\/s41579-020-00460-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Pu J, Liu Y, Zhang H, <i>et al<\/i>. An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Mol Psychiatry. 2021; 26:4265-4276.","DOI":"10.1038\/s41380-020-0645-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mortensen JK, Andersen G. Pharmacological management of post-stroke depression: an update of the evidence and clinical guidance. Expert Opin Pharmacother. 2021; 22:1157-1166.","DOI":"10.1080\/14656566.2021.1880566"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Zhu L, Han R, He L, Pan B, Zhong W, Li Y, Liu X. Innovative strategies for post-stroke depression: integrating traditional Chinese medicine with neurobiological insights, including the gut-brain axis. Front Pharmacol. 2025; 16:1539357.","DOI":"10.3389\/fphar.2025.1539357"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Yuan J, Yan F, Li W, Yuan G. Network pharmacological analysis of Xuefu Zhuyu decoction in the treatment of atherosclerosis. Front Pharmacol. 2022; 13:1069704.","DOI":"10.3389\/fphar.2022.1069704"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Wang X, Xing X, Huang P, Zhang Z, Zhou Z, Liang L, Yao R, Wu X, Yang L. A Chinese classical prescription Xuefu Zhuyu decoction in the treatment of coronary heart disease: An overview. Heliyon. 2024; 10:e28919.","DOI":"10.1016\/j.heliyon.2024.e28919"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Han H, Wu LM, Yang WM, Wang MX, Tang JJ, Wang H, Liu ZX, Liu RZ, Dong T, Zhang J, Yang B, Han MX. Characteristics of traditional Chinese medicine syndromes in post-stroke depression. Zhong Xi Yi Jie He Xue Bao. 2010; 8:427-431.","DOI":"10.3736\/jcim20100505"},{"key":"18","unstructured":"18. Lu LL, Shen XH, Chen JX. Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013; 33:638-640."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P, Macri J, McCoy KD, Verdu EF, Collins SM. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011; 141:599-609, 609.e591-593.","DOI":"10.1053\/j.gastro.2011.04.052"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. O&apos;Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O&apos;Toole PW, Dinan TG, Cryan JF. Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats. Neuroscience. 2014; 277:885-901.","DOI":"10.1016\/j.neuroscience.2014.07.054"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Duan J, Lin J, Zhang N, Wang Q, Li N, Yao K. Effect of Xuefu Zhuyu Capsule on Myocardial Infarction: Network Pharmacology and Experimental Verification. Evid Based Complement Alternat Med. 2023; 2023:5652276.","DOI":"10.1155\/2023\/5652276"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Bai L, Zhang D, Cui TT, Li JF, Gao YY, Wang NY, Jia PL, Zhang HY, Sun ZR, Zou W, Wang L. Mechanisms Underlying the Antidepressant Effect of Acupuncture <i>via<\/i> the CaMK Signaling Pathway. Front Behav Neurosci. 2020; 14:563698.","DOI":"10.3389\/fnbeh.2020.563698"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Li J, Sha L, Xu Q. An early increase in glutamate is critical for the development of depression-like behavior in a chronic restraint stress (CRS) model. Brain Res Bull. 2020; 162:59-66.","DOI":"10.1016\/j.brainresbull.2020.05.013"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Mour\u00e3o AM, Vicente LCC, Abreu MNS, Vale Sant&apos;Anna R, Vieira ELM, de Souza LC, de Miranda AS, Rachid MA, Teixeira AL. Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019; 28:735-740.","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.11.013"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sicard KM, Fisher M. Animal models of focal brain ischemia. Exp Transl Stroke Med. 2009; 1:7.","DOI":"10.1186\/2040-7378-1-7"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Bogdanova OV, Kanekar S, D&apos;Anci KE, Renshaw PF. Factors influencing behavior in the forced swim test. Physiol Behav. 2013; 118:227-239.","DOI":"10.1016\/j.physbeh.2013.05.012"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Hamon M, Blier P. Monoamine neurocircuitry in depression and strategies for new treatments. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 45:54-63.","DOI":"10.1016\/j.pnpbp.2013.04.009"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Davey CG, Y\u00fccel M, Allen NB. The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward. Neurosci Biobehav Rev. 2008; 32:1-19.","DOI":"10.1016\/j.neubiorev.2007.04.016"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Bai F, Hu N, Yang R, Qu LY, Ma S, Huang J, Wang JH, Yang BF, Li CL. Tongmai granules improve rat hippocampal injury by regulating TLR4\/MyD88\/AP-1 signaling pathway. J Ethnopharmacol. 2022; 285:114874.","DOI":"10.1016\/j.jep.2021.114874"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wu Q, Chen J, Yue J, Ying X, Zhou Y, Chen X, Tu W, Lou X, Yang G, Zhou K, Jiang S. Electroacupuncture improves neuronal plasticity through the A2AR\/cAMP\/PKA signaling pathway in SNL rats. Neurochem Int. 2021; 145:104983.","DOI":"10.1016\/j.neuint.2021.104983"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Micalizzi G, Buzzanca C, Chiaia V, Mondello M, Cacciola F, Caccamo D, Mondello L. Measurement of short-chain fatty acids in human plasma by means of fast gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2024; 1235:124044.","DOI":"10.1016\/j.jchromb.2024.124044"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, Cui R. The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex. Neural Plast. 2017; 2017:6871089.","DOI":"10.1155\/2017\/6871089"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Han S, Li XX, Wei S, Zhao D, Ding J, Xu Y, Yu C, Chen Z, Zhou DS, Yuan TF. Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study. Cell Rep Med. 2023; 4:101060.","DOI":"10.1016\/j.xcrm.2023.101060"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019; 16:461-478.","DOI":"10.1038\/s41575-019-0157-3"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, Parnes JA, Furuta GT, Rivera-Nieves J, Eltzschig HK. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut. 2012; 61:695-705.","DOI":"10.1136\/gutjnl-2011-300012"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Wang Y, Shi Y, Li W, Wang S, Zheng J, Xu G, Li G, Shen X, Yang J. Gut microbiota imbalance mediates intestinal barrier damage in high-altitude exposed mice. FEBS J. 2022; 289:4850-4868.","DOI":"10.1111\/febs.16409"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Li B, Yang W, Ge T, Wang Y, Cui R. Stress induced microglial activation contributes to depression. Pharmacol Res. 2022; 179:106145.","DOI":"10.1016\/j.phrs.2022.106145"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. Prevalence of Depression in the Community from 30 Countries between 1994 and 2014. Sci Rep. 2018; 8:2861.","DOI":"10.1038\/s41598-018-21243-x"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Soca\u0142a K, Doboszewska U, Szopa A, Serefko A, W\u0142odarczyk M, Zieli\u0144ska A, Poleszak E, Fichna J, Wla\u017a P. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacol Res. 2021; 172:105840.","DOI":"10.1016\/j.phrs.2021.105840"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Hu W, Kong X, Wang H, Li Y, Luo Y. Ischemic stroke and intestinal flora: an insight into brain-gut axis. Eur J Med Res. 2022; 27:73.","DOI":"10.1186\/s40001-022-00691-2"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Simpson CA, Diaz-Arteche C, Eliby D, Schwartz OS, Simmons JG, Cowan CSM. The gut microbiota in anxiety and depression - A systematic review. Clin Psychol Rev. 2021; 83:101943.","DOI":"10.1016\/j.cpr.2020.101943"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Ding W, Wang L, Li L, Li H, Wu J, Zhang J, Wang J. Pathogenesis of depression and the potential for traditional Chinese medicine treatment. Front Pharmacol. 2024; 15:1407869.","DOI":"10.3389\/fphar.2024.1407869"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Li P, Wu M, Xiong W, Li J, An Y, Ren J, Xie Y, Xue H, Yan D, Li M, Zhong G. Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF- \u03baB activation and modulating the gut microbiota in mice. Int Immunopharmacol. 2020; 81:106288.","DOI":"10.1016\/j.intimp.2020.106288"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Liu C, Wu Y, Wang Y, Yang F, Ren L, Wu H, Yu Y. Integrating 16 S rRNA gene sequencing and metabolomics analysis to reveal the mechanism of Angelica sinensis oil in alleviating ulcerative colitis in mice. J Pharm Biomed Anal. 2024; 249:116367.","DOI":"10.1016\/j.jpba.2024.116367"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Lv H, Jia H, Cai W, Cao R, Xue C, Dong N. Rehmannia glutinosa polysaccharides attenuates colitis <i>via<\/i> reshaping gut microbiota and short-chain fatty acid production. J Sci Food Agric. 2023; 103:3926-3938.","DOI":"10.1002\/jsfa.12326"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Yan BF, Chen X, Chen YF, Liu SJ, Xu CX, Chen L, Wang WB, Wen TT, Zheng X, Liu J. Aqueous extract of Paeoniae Radix Alba (Paeonia lactiflora Pall.) ameliorates DSS-induced colitis in mice by tunning the intestinal physical barrier, immune responses, and microbiota. J Ethnopharmacol. 2022; 294:115365.","DOI":"10.1016\/j.jep.2022.115365"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Ji W, Jiang T, Sun Z, Teng F, Ma C, Huang S, Yan S. The Enhanced Pharmacological Effects of Modified Traditional Chinese Medicine in Attenuation of Atherosclerosis Is Driven by Modulation of Gut Microbiota. Front Pharmacol. 2020; 11:546589.","DOI":"10.3389\/fphar.2020.546589"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Leclercq S, Matamoros S, Cani PD, Neyrinck AM, Jamar F, St\u00e4rkel P, Windey K, Tremaroli V, B\u00e4ckhed F, Verbeke K, de Timary P, Delzenne NM. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci U S A. 2014; 111:E4485-4493.","DOI":"10.1073\/pnas.1415174111"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN. A novel antiinflammatory role for the short-chain fatty acids in human labor. Endocrinology. 2012; 153:395-403.","DOI":"10.1210\/en.2011-1457"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Huang G, Zheng Y, Zhang N, Huang G, Zhang W, Li Q, Ren X. <i>Desulfovibrio vulgaris<\/i> caused gut inflammation and aggravated DSS-induced colitis in C57BL\/6 mice model. Gut Pathog. 2024; 16:39.","DOI":"10.1186\/s13099-024-00632-w"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. O&apos;Connor JC, Lawson MA, Andr\u00e9 C, Moreau M, Lestage J, Castanon N, Kelley KW, Dantzer R. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry. 2009; 14:511-522.","DOI":"10.1038\/sj.mp.4002148"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Liu G, Tang J, Zhou J, Dong M. Short-chain fatty acids play a positive role in colorectal cancer. Discov Oncol. 2024; 15:425.","DOI":"10.1007\/s12672-024-01313-5"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Mohamed Elfadil O, Mundi MS, Abdelmagid MG, Patel A, Patel N, Martindale R. Butyrate: More Than a Short Chain Fatty Acid. Curr Nutr Rep. 2023; 12:255-262.","DOI":"10.1007\/s13668-023-00461-4"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Corr\u00eaa-Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MA. Regulation of immune cell function by short-chain fatty acids. Clin Transl Immunology. 2016; 5:e73.","DOI":"10.1038\/cti.2016.17"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Kelly JR, Borre Y, C OB, <i>et al.<\/i> Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res. 2016; 82:109-118.","DOI":"10.1016\/j.jpsychires.2016.07.019"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry. 2007; 62:55-64.","DOI":"10.1016\/j.biopsych.2006.06.036"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Brown AJ, Goldsworthy SM, Barnes AA, <i>et al.<\/i> The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003; 278:11312-11319.","DOI":"10.1074\/jbc.M211609200"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Erny D, Hrab\u011b de Angelis AL, Jaitin D, <i>et al<\/i>. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015; 18:965-977.","DOI":"10.1038\/nn.4030"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Huang Y, Wu J, Zhang H, <i>et al<\/i>. The gut microbiome modulates the transformation of microglial subtypes. Mol Psychiatry. 2023; 28:1611-1621.","DOI":"10.1038\/s41380-023-02017-y"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Xu K, Wang G, Gong J, Yang X, Cheng Y, Li D, Sheng S, Zhang F. Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation. Int Immunopharmacol. 2025; 152:114374.","DOI":"10.1016\/j.intimp.2025.114374"}],"container-title":["Drug Discoveries &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/20\/1\/20_2025.01120\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:39:00Z","timestamp":1772858340000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ddt\/20\/1\/20_2025.01120\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.5582\/ddt.2025.01120","relation":{},"ISSN":["1881-7831","1881-784X"],"issn-type":[{"value":"1881-7831","type":"print"},{"value":"1881-784X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"article-number":"2025.01120"}}