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Goto M, Miller RW. From premature gray hair to helicase-Werner syndrome: Implications for aging and cancer. In: Monograph on Cancer Research. No.49, Japan Scientific Societies press & Karger, Tokyo, Japan, 2001."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Goto M, Sugimoto K, Hayashi S, Ogino T, Sugimoto M, Furuichi Y, Matsuura M, Ishikawa Y, Iwaki-Egawa S, Watanabe Y. Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome. Exp Gerontol. 2012; 47:936-939.","DOI":"10.1016\/j.exger.2012.08.010"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular diseases. Circ Res. 2004; 95:858-866.","DOI":"10.1161\/01.RES.0000146672.10582.17"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kollmann TR, Levy O, Montgomery RR, Goriely S. Innate immune function by Toll-like receptors: Distinct responses in newborns and the elderly. Immunity. 2012; 37:771-783.","DOI":"10.1016\/j.immuni.2012.10.014"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kolattukudy PE, Niu J. Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1\/CCR2 pathway. Circ Res. 2012; 110:174-189.","DOI":"10.1161\/CIRCRESAHA.111.243212"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond). 2014; 38:170-176.","DOI":"10.1038\/ijo.2013.82"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci. 2000; 908:244-254.","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"key":"8","unstructured":"8. Goto M. Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? BioSci Trends. 2008; 2:218-230."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Balkwill F, Coussens LM. Cancer: An inflammatory link. Nature. 2004; 431:405-406.","DOI":"10.1038\/431405a"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013; 13:875-887.","DOI":"10.1038\/nri3547"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Mold C, Rodriguez W, Rodic-Polic B, Du Clos TW. C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol. 2002; 169:7019-7025.","DOI":"10.4049\/jimmunol.169.12.7019"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Shurin GV, Yurkovetsky ZR, Chatta GS, Tourkova IL, Shurin MR, Lokshin AE. Dynamic alteration of soluble serum biomarkers in healthy aging. Cytokine. 2007; 39:123-129.","DOI":"10.1016\/j.cyto.2007.06.006"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Kim HO, Kim HS, Youn JC, Shin EC, Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med. 2011; 9:113.","DOI":"10.1186\/1479-5876-9-113"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Miles EA, Rees D, Baneriee T, Cazzola R, Lewis S, Wood R, Oates R, Tallant A, Cestaro B, Yagoob P, Wahle KW, Calder PC. Age-related increase in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations. Atherosclerosis. 2008; 196:298-305.","DOI":"10.1016\/j.atherosclerosis.2006.11.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Inadera H, Egashira K, Takemoto M, Ouchi Y, Matsushima K. Increase in circulating levels of monocyte chemoattractant protein-1 with aging. J Inteferon Cytokine Res. 1999; 19:1179-1182.","DOI":"10.1089\/107999099313127"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Antonelli A, Rotondi M, Fallahi P, Ferrari SM, Paolicchi A, Romaqnani P, Serio M, Ferrannini E. Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing. Cytokine. 2006; 34:32-38.","DOI":"10.1016\/j.cyto.2006.03.012"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes N, Muller-Hermelink HK, Steinmann GG. Admission criteria for immunogerontological studies in man: The SENIEUR protocol. Mech Ageing Dev. 1984; 28:47-55.","DOI":"10.1016\/0047-6374(84)90152-0"},{"key":"18","unstructured":"18. Akaike H. Information theory and extension of the maximum likelihood principle. B.N. Petrov, F. Csaki (Eds.), Proceedings of the 2nd International Symposium on Information Theory, Akademiai Kiado, Budapest, 1973; pp. 267-281."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Ihaka R, Gentleman R. R: A language for data analysis and graphics. J Comp Grap Stat. 1996; 5:299-314.","DOI":"10.1080\/10618600.1996.10474713"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sakurai T, Iimuro S, Araki A, Umegaki H, Ohashi Y, Yokono K, Lto H. Age-associated increase in abdominal obesity and insulin resistance, and usefulness of AHA\/NHLBI definition of metabolic syndrome for predicting cardiovascular disease in Japanese elderly with type 2 diabetes mellitus. Gerontology. 2010; 56:141-149.","DOI":"10.1159\/000246970"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, Curhan GC, Rifai N, Cannuscio CC, Stampfer MJ, Rimm EB. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med.2004; 351:2599-2610.","DOI":"10.1056\/NEJMoa040967"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wakugawa Y, Kiyohara Y, Tanizaki Y, Kubo M, Ninomiya T, Hata J, Doi Y, Okubo K, Oishi Y, Shikata K, Yonemoto K,Maebuchi D, Ibayashi S, Iida M. C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: The Hisayama study. Stroke. 2006; 37:27-32.","DOI":"10.1161\/01.STR.0000194958.88216.87"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Ishikawa J, Tamura Y, Hoshide S, Eguchi K, Ishikawa S, Shimada K, Kario K. Low-grade inflammation is a risk factor for clinical stroke events in addition to silentcerebral infarcts in Japanese older hypertensives: The Jichi Medical School ABPM Study, wave 1. Stroke. 2007; 38:911-917.","DOI":"10.1161\/01.STR.0000258115.46765.f1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. 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Immunity. 2004; 21:643-653.","DOI":"10.1016\/j.immuni.2004.09.009"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Du Clos TW. C-reactive protein as a regulator of autoimmunity and inflammation, Arthritis Rheum. 2003; 48:1475-1477.","DOI":"10.1002\/art.11025"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008; 8:958-969.","DOI":"10.1038\/nri2448"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Harris J, De Haro SA, Master SS, Keane J, Roberts EA, Delgado M, Deretic V. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity. 2007; 27:505-517.","DOI":"10.1016\/j.immuni.2007.07.022"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Mansfield AS, Nevala WK, Dronca RS, Leontovich AA, Shuster L, Markovic SN. 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