{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:44:01Z","timestamp":1761965041063},"reference-count":37,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IRDR"],"published-print":{"date-parts":[[2018,11,30]]},"DOI":"10.5582\/irdr.2018.01103","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T22:17:38Z","timestamp":1544998658000},"page":"236-244","source":"Crossref","is-referenced-by-count":12,"title":["Uptake and radiological findings of screening cerebral magnetic resonance scans in patients with hereditary haemorrhagic telangiectasia"],"prefix":"10.5582","volume":"7","author":[{"given":"Gavin","family":"Fatania","sequence":"first","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Gilson","sequence":"additional","affiliation":[{"name":"NHLI Cardiovascular Sciences, Imperial College London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Glover","sequence":"additional","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alsafi","sequence":"additional","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust"},{"name":"VASCERN HHT European Reference Centre, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust"},{"name":"VASCERN HHT European Reference Centre, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maneesh C","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Imaging, Imperial College Healthcare NHS Trust"},{"name":"VASCERN HHT European Reference Centre, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire L.","family":"Shovlin","sequence":"additional","affiliation":[{"name":"NHLI Cardiovascular Sciences, Imperial College London"},{"name":"VASCERN HHT European Reference Centre, Imperial College Healthcare NHS Trust"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Shovlin CL. Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment. Blood Rev. 2010; 24:203-219.","DOI":"10.1016\/j.blre.2010.07.001"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kjeldsen AD, Vase P, Green A. Hereditary haemorrhagic telangiectasia: A population-based study of prevalence and mortality in Danish patients. J Intern Med. 1999; 245:31-39.","DOI":"10.1046\/j.1365-2796.1999.00398.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bideau A, Brunet G, Heyer E, Plauchu H, Robert JM. An abnormal concentration of cases of Rendu-Osler disease in the Valserine valley of the French Jura: A geneological and demographic study. Ann of Hum Biol. 1992; 19:233-247.","DOI":"10.1080\/03014469200002112"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dakeishi M, Shioya T, Wada Y, Shindo T, Otaka K, Manabe M, Nozaki J, Inoue S, Koizumi A. Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan. Hum Mutat. 2002; 19:140-148.","DOI":"10.1002\/humu.10026"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Westermann CJ, Rosina AF, De Vries V, de Coteau PA. The prevalence and manifestations of hereditary hemorrhagic telangiectasia in the Afro-Caribbean population of the Netherlands Antilles: A family screening. Am J Med Genet A. 2003; 116A:324-328.","DOI":"10.1002\/ajmg.a.10002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Cottin V, Plauchu H, Bayle JY, Barthelet M, Revel D, Cordier JF. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia. Am J Respir Crit Care Med. 2004; 169:994-1000.","DOI":"10.1164\/rccm.200310-1441OC"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Buscarini E, Leandro G, Conte D, <i>et al<\/i>. Natural history and outcome of hepatic vascular malformations in a large cohort of patients with hereditary hemorrhagic teleangiectasia. Dig Dis Sci. 2011; 56:2166-2178.","DOI":"10.1007\/s10620-011-1585-2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Krings T, Ozanne A, Chng SM, Alvarez H, Rodesch G, Lasjaunias PL. Neurovascular phenotypes in hereditary haemorrhagic telangiectasia patients according to age. Review of 50 consecutive patients aged 1 day-60 years. Neuroradiology. 2005; 47:711-720.","DOI":"10.1007\/s00234-005-1390-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Woodall MN, McGettigan M, Figueroa R, Gossage JR, Alleyne CH Jr. Cerebral vascular malformations in hereditary hemorrhagic telangiectasia. J Neurosurg. 2014; 120:87-92.","DOI":"10.3171\/2013.10.JNS122402"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Brinjikji W, Iyer VN, Wood CP, Lanzino G. Prevalence and characteristics of brain arteriovenous malformations in hereditary hemorrhagic telangiectasia: A systematic review and meta-analysis. J Neurosurg. 2017; 127:302-310.","DOI":"10.3171\/2016.7.JNS16847"},{"key":"11","unstructured":"11. Cure HHT. HHT and Stroke. <i>https:\/\/curehht.org\/wp-content\/uploads\/2017\/11\/FACT-SHEET-HHT-and-Stroke.pdf<\/i> (accessed August 27, 2018)."},{"key":"12","unstructured":"12. HHT Ireland. HHT-The Facts. <i>https:\/\/hhtireland.org\/the-facts<\/i> (accessed August 27, 2018)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Shovlin CL, Condliffe R, Donaldson JW, Kiely DG, Wort SJ; British Thoracic Society. British thoracic society clinical statement on pulmonary arteriovenous malformations. Thorax. 2017; 72:1154-1163.","DOI":"10.1136\/thoraxjnl-2017-210764"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Shovlin CL, Jackson JE, Bamford KB, Jenkins IH, Benjamin AR, Ramadan H, Kulinskaya E. Primary determinants of ischaemic stroke\/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia. Thorax. 2008; 63:259-266.","DOI":"10.1136\/thx.2007.087452"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Gill SS, Roddie ME, Shovlin CL, Jackson JE. Pulmonary arteriovenous malformations and their mimics. Clin Radiol. 2015; 70:96-110.","DOI":"10.1016\/j.crad.2014.09.003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Shovlin CL, Chamali B, Santhirapala V, Livesey JA, Angus G, Manning R, Laffan MA, Meek J, Tighe HC, Jackson JE. Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: Associations with iron deficiency and platelets. PLoS One. 2014; 9:e88812.","DOI":"10.1371\/journal.pone.0088812"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Boother EJ, Brownlow S, Tighe HC, Bamford KB, Jackson JE, Shovlin CL. Cerebral abscess associated with odontogenic bacteremias, hypoxemia, and iron loading in immunocompetent patients with right-to-left shunting through pulmonary arteriovenous malformations. Clin Infect Dis. 2017; 65:595-603.","DOI":"10.1093\/cid\/cix373"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Faughnan ME, Palda VA, Garcia-Tsao G, <i>et al<\/i>. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet. 2011; 48:73-87.","DOI":"10.1136\/jmg.2009.069013"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Easey AJ, Wallace GM, Hughes JM, Jackson JE, Taylor WJ, Shovlin CL. Should asymptomatic patients with hereditary haemorrhagic telangiectasia (HHT) be screened for cerebral vascular malformations? Data from 22,061 years of HHT patient life. J Neurol Neurosurg Psychiatry. 2003; 74:743-748.","DOI":"10.1136\/jnnp.74.6.743"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Mohr JP, Parides MK, Stapf C, <i>et al<\/i>. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): A multicentre, non-blinded, randomised trial. Lancet. 2014; 383:614-621.","DOI":"10.1016\/S0140-6736(13)62302-8"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Willemse RB, Mager JJ, Westermann CJ, Overtoom TT, Mauser H, Wolbers JG. Bleeding risk of cerebrovascular malformations in hereditary hemorrhagic telangiectasia. J Neurosurg. 2000; 92:779-784.","DOI":"10.3171\/jns.2000.92.5.0779"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Yang W, Liu A, Hung AL, Braileanu M, Wang JY, Caplan JM, Colby GP, Coon AL, Tamargo RJ, Ahn ES, Huang J. Lower risk of intracranial arteriovenous malformation hemorrhage in patients with hereditary hemorrhagic telangiectasia. Neurosurgery. 2016; 78:684-693.","DOI":"10.1227\/NEU.0000000000001103"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Shovlin CL, Buscarini E, Kjeldsen AD, Mager HJ, Sabba C, Droege F, Geisthoff U, Ugolini S, Dupuis Girod S. European Reference Network For Rare Vascular Diseases (VASCERN) outcome measures for hereditary haemorrhagic telangiectasia (HHT). Orphanet J Rare Dis. 2018; 13:136.","DOI":"10.1186\/s13023-018-0850-2"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Shovlin CL, Sodhi V, McCarthy A, Lasjaunias P, Jackson JE, Sheppard MN. Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): Suggested approach for obstetric services. BJOG. 2008; 115:1108-1115.","DOI":"10.1111\/j.1471-0528.2008.01786.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Moussouttas M, Fayad P, Rosenblatt M, Hashimoto M, Pollak J, Henderson K, Ma TY, White RI. Pulmonary arteriovenous malformations: Cerebral ischemia and neurologic manifestations. Neurology. 2000; 55: 959-964.","DOI":"10.1212\/WNL.55.7.959"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Elphick A, Shovlin CL. Relationships between epistaxis, migraines, and triggers in hereditary hemorrhagic telangiectasia. Laryngoscope. 2014; 124:1521-1528.","DOI":"10.1002\/lary.24526"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Patel T, Elphick A, Jackson JE, Shovlin CL. Injections of intravenous contrast for computerized tomography scans precipitate migraines in hereditary hemorrhagic telangiectasia subjects at risk of paradoxical emboli: Implications for right-to-left shunt risks. Headache. 2016; 56:1659-1663.","DOI":"10.1111\/head.12963"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Post MC, Thijs V, Schonewille WJ, Budts W, Snijder RJ, Plokker HW, Westermann CJ. Embolization of pulmonary arteriovenous malformations and decrease in prevalence of migraine. Neurology. 2006; 66:202-205.","DOI":"10.1212\/01.wnl.0000194257.75559.b0"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Santhirapala V, Chamali B, McKernan H, Tighe HC, Williams LC, Springett JT, Bellenberg HR, Whitaker AJ, Shovlin CL. Orthodeoxia and postural orthostatic tachycardia in patients with pulmonary arteriovenous malformations: A prospective 8-year series. Thorax. 2014; 69:1046-1047.","DOI":"10.1136\/thoraxjnl-2014-205289"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Vlak MH, Algra A, Brandenburg R, Rinkel GJ. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis. Lancet Neurol. 2011; 10:626-636.","DOI":"10.1016\/S1474-4422(11)70109-0"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Rom\u00e1n G, Fisher M, Perl DP, Poser CM. Neurological manifestations of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): Report of 2 cases and review of the literature. Ann Neurol. 1978; 4:130-144.","DOI":"10.1002\/ana.410040207"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Brinjikji W, Nasr DM, Wood CP, Iyer VN. Pulmonary arteriovenous malformations are associated with silent brain infarcts in hereditary hemorrhagic telangiectasia patients. Cerebrovasc Dis. 2017; 44:179-185.","DOI":"10.1159\/000478734"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Savitz SI, Caplan LR. Vertebrobasilar disease. N Engl J Med. 2005; 352:2618-2626.","DOI":"10.1056\/NEJMra041544"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Arboix A, Alio J. Acute cardioembolic cerebral infarction: Answers to clinical questions. Curr Cardiol Rev. 2012; 8:54-67.","DOI":"10.2174\/157340312801215791"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Caplan LR, Wityk RJ, Glass TA, <i>et al<\/i>. New England Medical Center Posterior Circulation registry. Ann Neurol. 2004; 56:389-398.","DOI":"10.1002\/ana.20204"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Devlin HL, Hosman AE, Shovlin CL. Antiplatelet and anticoagulant agents in hereditary hemorrhagic telangiectasia. N Engl J Med. 2013; 368:876-878.","DOI":"10.1056\/NEJMc1213554"},{"key":"37","unstructured":"37. VASCERN Do&apos;s And Don&apos;ts Factsheets For Hereditary Haemorrhagic Telangiectasia Patients Facing Frequent Situations. <i>https:\/\/vascern.eu\/wp-content\/uploads\/2018\/09\/Fiches_Hereditary-Haemorrhagic-Telangiectasia_FINAL-web.pdf <\/i>(Accessed November 7th .2018)"}],"container-title":["Intractable &amp; Rare Diseases Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/irdr\/7\/4\/7_2018.01103\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T04:46:48Z","timestamp":1545454008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/irdr\/7\/4\/7_2018.01103\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,30]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5582\/irdr.2018.01103","relation":{},"ISSN":["2186-361X","2186-3644"],"issn-type":[{"value":"2186-361X","type":"electronic"},{"value":"2186-3644","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,30]]}}}