{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:02:06Z","timestamp":1757617326585,"version":"3.44.0"},"reference-count":40,"publisher":"International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IRDR"],"published-print":{"date-parts":[[2025,8,31]]},"DOI":"10.5582\/irdr.2025.01032","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T22:07:23Z","timestamp":1754690843000},"page":"175-182","source":"Crossref","is-referenced-by-count":0,"title":["Secondary musculoskeletal disability and rehabilitation aspects in adults with thalidomide embryopathy: A narrative review"],"prefix":"10.5582","volume":"14","author":[{"given":"Nobuhiko","family":"Haga","sequence":"first","affiliation":[{"name":"National Rehabilitation Center for Persons with Disabilities, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Fujitani","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, National Center for Global Health and Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nihon Institute of Medical Science, Saitama, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, the University of Tokyo, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroji","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Health, Department of Social Medicine, Shiga University of Medical Science, Otsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Shirahoshi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Health Sciences, Bukkyo University, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3542","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Lenz W. A short history of thalidomide embryopathy. Teratology. 1988; 38:203-215.","DOI":"10.1002\/tera.1420380303"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Smithells RW, Newman CG. Recognition of thalidomide defects. J Med Genet. 1992; 29:716-723.","DOI":"10.1136\/jmg.29.10.716"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Lenz W, Knapp K. Thalidomide embryopathy. Arch Environ Health. 1962; 5:100-105.","DOI":"10.1080\/00039896.1962.10663250"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hamanishi C. Congenital short femur. Clinical, genetic and epidemiological comparison of the naturally occurring condition with that caused by thalidomide. J Bone Joint Surg Br. 1980; 62:307-320.","DOI":"10.1302\/0301-620X.62B3.7410462"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Edwards DH, Nichols PJ. The spinal abnormalities in thalidomide embryopathy. Acta Orthop Scand. 1977; 48:273-276.","DOI":"10.3109\/17453677708988767"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Croci DM, Dalolio M, Schaeren S, Wasner MG, Mariani L, Jost GF. Thalidomide embryopathy as possible cause of anterior sacral meningocele: A case report. Birth Defects Res. 2017; 109:1390-1392.","DOI":"10.1002\/bdr2.1124"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Maizer WA. Thalidomide embryopathy and limb defects; Experiences in habilitation of children with ectromelias. Arch Dis Child. 1965; 40:154-157.","DOI":"10.1136\/adc.40.210.154"},{"key":"8","unstructured":"8. Mongeau M, Gingras G, Sherman ED, Hebert B, Hutchison J, Corriveau C. Medical and psychosocial aspects of the habilitation of thalidomide children. Can Med Assoc J. 1966; 95:390-395."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gillis L. Thalidomide babies: Management of limb defects. Br Med J. 1962; 2:647-651.","DOI":"10.1136\/bmj.2.5305.647"},{"key":"10","unstructured":"10. Gilpin RE. Habilitation of patients with congenital malformations associated with thalidomide: prosthetic aspects. Can Med Assoc J. 1963; 88:973-979."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Fletcher I. Review of the treatment of thalidomide children with limb deficiency in Great Britain. Clin Orthop Relat Res. 1980; 148:18-25.","DOI":"10.1097\/00003086-198005000-00004"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Bent N, Tennant A, Neumann V, Chamberlain MA. Living with thalidomide: Health status and quality of life at 40 years. Prosthet Orthot Int. 2007; 31:147-156.","DOI":"10.1080\/03093640600988567"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. O&apos;Carroll A, O&apos;Reilly F, Whitford DL. What has happened to people affected by thalidomide 50 years on? Ir J Med Sci. 2011; 180:475-478.","DOI":"10.1007\/s11845-011-0683-7"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ghassemi Jahani SA, Karlsson J, Brisby H, Danielsson AJ. Health-related quality of life and function in middle-aged individuals with thalidomide embryopathy. J Child Orthop. 2016; 10:691-703.","DOI":"10.1007\/s11832-016-0797-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Newbronner E, Atkin K. The changing health of Thalidomide survivors as they age: A scoping review. Disabil Health J. 2018; 11:184-191.","DOI":"10.1016\/j.dhjo.2017.09.004"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Sagoe K, Owens WA, Loyd R, Varley R. The impact of ageing on the health and wellbeing of people with thalidomide embryopathy: A comparison of the health impact with the general population. Disabil Rehabil. 2024; 46:5029-5037.","DOI":"10.1080\/09638288.2024.2307357"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Markiewicz M, Stirling P, Brennan S, Hooper G, Lam W. Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom. J Hand Surg Eur. 2023; 48:773-780.","DOI":"10.1177\/17531934231164093"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Nicotra A, Newman C, Johnson M, Eremin O, Friede T, Malik O, Nicholas R. Peripheral nerve dysfunction in middle-aged subjects born with thalidomide embryopathy. PLoS One. 2016; 11:e0152902.","DOI":"10.1371\/journal.pone.0152902"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Jankelowitz SK, Spies JM, Burke D. Late-onset neurological symptoms in thalidomide-exposed subjects: A study of an Australasian cohort. Eur J Neurol. 2013; 20:509-514.","DOI":"10.1111\/ene.12005"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Kimura H, Ikuta Y, Ishida O. Carpal tunnel syndrome in radial dysplasia. J Hand Surg Br. 2001; 26:533-536.","DOI":"10.1054\/jhsb.2001.0653"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Oshima Y, Okutsu I, Hamanaka I, Motomura T. Carpal tunnel syndrome accompanying radial dysplasia due to thalidomide embryopathy. J Hand Surg Br. 2006; 31:342-344.","DOI":"10.1016\/J.JHSB.2006.01.001"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Newman RJ. Shoulder joint replacement for osteoarthrosis in association with thalidomide-induced phocomelia. Clin Rehabil. 1999; 13:250-252.","DOI":"10.1191\/026921599675691977"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Merkle TP, Beckmann N, Bruckner T, Zeifang F. Shoulder joint replacement can improve quality of life and outcome in patients with dysmelia: A case series. BMC Musculoskelet Disord. 2016; 17:185.","DOI":"10.1186\/s12891-016-1031-x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kimmeyer M, Lehmann LJ, Gerhardt C, Schmalzl J. Development and function of a natural reverse shoulder in a patient with thalidomide-induced dysmelia. JSES Rev Rep Tech. 2021; 1:60-64.","DOI":"10.1016\/j.xrrt.2020.11.009"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ghassemi Jahani SA, Danielson B, Karlsson J, Danielsson AJ. Long-term follow-up of thalidomide embryopathy: malformations and development of osteoarthritis in the lower extremities and evaluation of upper extremity function. J Child Orthop. 2014; 8:423-433","DOI":"10.1007\/s11832-014-0609-9"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kamimura C, Fujitani J, Aizawa I, Saotome I, Fujiwara S, Haga N. Skeletal computed tomography findings of upper extremities in middle-aged persons with thalidomide embryopathy. Intractable Rare Dis Res. 2024; 13:185-189.","DOI":"10.5582\/irdr.2024.01035"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Imai K, Sone H, Otomo K, Nakano Y, Hinoshita F. Quality of life and pain in patients with thalidomide embryopathy in Japan. Mol Genet Genomic Med. 2020; 8:e1464.","DOI":"10.1002\/mgg3.1464"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ghassemi Jahani SA, Danielsson A, Ab-Fawaz R, Hebelka H, Danielson B, Brisby H. Degenerative changes in the cervical spine are more common in middle-aged individuals with thalidomide embryopathy than in healthy controls. PLoS One. 2016; 11:e0155493.","DOI":"10.1371\/journal.pone.0155493"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ghassemi Jahani SA, Danielsson A, Karlsson J, Brisby H. Middle-aged individuals with thalidomide embryopathy have undergone few surgical limb procedures and demonstrate a high degree of physical independence. PLoS One. 2017; 12:e0186388.","DOI":"10.1371\/journal.pone.0186388"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Fahlbusch H, Ohlmeier M, Mau H, Ballhause T, Citak M, Gehrke T, Korth M. Total knee arthroplasty and patelloplasty in a patient with phocomelia caused by thalidomide. SAGE Open Med Case Rep. 2023; 11:2050313X231154635.","DOI":"10.1177\/2050313X231154635"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Hodo T, Hamrick M, Melenevsky Y. Complex anatomic abnormalities of the lower leg muscles and tendons associated with phocomelia: a case report. J Foot Ankle Surg. 2017; 56:1335-1338.","DOI":"10.1053\/j.jfas.2017.06.008"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Newbronner E, Glendinning C, Atkin K, Wadman R. The health and quality of life of Thalidomide survivors as they age - Evidence from a UK survey. PLoS One. 2019; 14:e0210222.","DOI":"10.1371\/journal.pone.0210222"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Niecke A, Peters KM, Alayli A, L\u00fcngen M, Pfaff H, Albus C, Samel C. Health-related quality of life after 50 years in individuals with thalidomide embryopathy: Evidence from a German cross-sectional survey. Birth Defects Res. 2022; 114:714-724.","DOI":"10.1002\/bdr2.2051"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Nippert I, Edler B, Schmidt-Herterich C. 40 years later: The health related quality of life of women affected by thalidomide. Community Genet. 2002; 5:209-216.","DOI":"10.1159\/000066691"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Samel C, Albus C, Nippert I, Niecke A, L\u00fcngen M, Pfaff H, Peters KM. Life situation of women impaired by Thalidomide embryopathy in North Rhine-Westphalia - a comparative analysis of a recent cross-sectional study with earlier data. BMC Womens Health. 2019; 19:51.","DOI":"10.1186\/s12905-019-0745-y"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Hinoshita F, Beppu H, Shioji S, Fujitani J, Imai K, Tajima T, Tagami T, Ohnishi S. A nationwide survey regarding the life situations of patients with thalidomide embryopathy in Japan, 2018: First report. Birth Defects Res. 2019; 111:1633-1642.","DOI":"10.1002\/bdr2.1558"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Morrison D. Poor balance, bilateral upper limb phocomelia, no previous exercise: a challenging combination for fall prevention in a middle-aged thalidomide survivor. BMJ Case Rep. 2020; 13:e231345.","DOI":"10.1136\/bcr-2019-231345"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Burger H, Vidmar G. A survey of overuse problems in patients with acquired or congenital upper limb deficiency. Prosthet Orthot Int. 2016; 40:497-502.","DOI":"10.1177\/0309364615584658"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Mace J, Reddy S, Mohil R. Atypical carpal tunnel syndrome in a Holt Oram patient: a case report and literature review. Open Orthop J. 2014; 8:462-465.","DOI":"10.2174\/1874325001408010462"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Ekblom AG, Dahlin LB, Rosberg HE, Wiig M, Werner M, Arner M. Hand function in adults with radial longitudinal deficiency. J Bone Joint Surg Am. 2014; 96:1178-1184.","DOI":"10.2106\/JBJS.M.00815"}],"container-title":["Intractable &amp; Rare Diseases Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/irdr\/14\/3\/14_2025.01032\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:29:12Z","timestamp":1757132952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/irdr\/14\/3\/14_2025.01032\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5582\/irdr.2025.01032","relation":{},"ISSN":["2186-361X","2186-3644"],"issn-type":[{"type":"electronic","value":"2186-361X"},{"type":"print","value":"2186-3644"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"article-number":"2025.01032"}}