{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:43:02Z","timestamp":1771051382427,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:p>OBJECTIVES: To develop a diagnostic predictive model for the identification of patients with presumptive pulmonary tuberculosis (PTB) at high risk for active disease and those requiring nucleic acid amplification (NAAT) testing and\/or preventive respiratory isolation in low-incidence,\n high-income countries.DESIGN: A 1:1 case-control study was conducted in consecutive immunocompetent patients with presumed PTB hospitalised between 2009 and 2012 in Paris, France. Cases were defined as individuals with culture-confirmed PTB, regardless of smear result. Those with presumed\n PTB and three smear- and culture-negative samples were selected as controls. A score was derived using conditional logistic regression. Internal validity of the score was assessed using the bootstrap method.RESULTS: A total of 354 patients were included in the analysis (177 cases, 177\n controls). Among the 177 cases, 74 (42%) were smear-negative but culture-positive. Factors independently associated with PTB were age &lt;50 years (adjusted OR [aOR] 4.7, 95%CI 1.8\u201312), diabetes (aOR 3.2, 95%CI 1.1\u20139.8), absence of cough with or without sputum (aOR 3.7, 95%CI 1.7\u20138.3),\n fever &gt;15 days (aOR 3.5, 95%CI 1.3\u20139.5), apical infiltration without cavity (aOR 3.4, 95%CI 1.4\u20138.5) and cavitation or miliary pattern (aOR 19.7, 95%CI 7.6\u201351.1). Score C-index was 0.84 (95%CI 0.79\u20130.88). Calibration for the overall population (<jats:italic>P<\/jats:italic> = 0.770)\n and in smear-negative patients (<jats:italic>P<\/jats:italic> = 0.980) was appropriate. A score of \ue2f63.3 had 90% sensitivity, 50% specificity and 79% (IQR 28\u201395) median probability of PTB.CONCLUSIONS: This score could be used to build an algorithm to determine the need for respiratory isolation and\/or NAAT use in PTB disease.<\/jats:p>","DOI":"10.5588\/ijtld.17.0353","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T07:38:29Z","timestamp":1514965109000},"page":"1272-1279","source":"Crossref","is-referenced-by-count":7,"title":["Score for pulmonary tuberculosis in patients with clinical presumption of tuberculosis in a low-prevalence area"],"prefix":"10.5588","volume":"21","author":[{"given":"T.","family":"Delory","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ferrand","sequence":"additional","affiliation":[{"name":"APHP, Service de Maladies Infectieuses et Tropicales, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Grall","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Casalino","sequence":"additional","affiliation":[{"name":"Service d'Accueil des Urgences, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lafarge","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Melot","sequence":"additional","affiliation":[{"name":"APHP, Service de Maladies Infectieuses et Tropicales, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hajage","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Bichat-Claude Bernard, Paris, France; Centre d'Investigation Clinique 1425-EC, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1123, Epid\u00e9miologie Clinique et Evaluation Economique Appliqu\u00e9es aux Populations Vuln\u00e9rables, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Service de Virologie, H\u00f4pital Bichat-Claude Bernard, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aubier","sequence":"additional","affiliation":[{"name":"Service de Virologie, H\u00f4pital Bichat-Claude Bernard, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Tubach","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Bichat-Claude Bernard, Paris, France; Centre d'Investigation Clinique 1425-EC, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1123, Epid\u00e9miologie Clinique et Evaluation Economique Appliqu\u00e9es aux Populations Vuln\u00e9rables, Paris, France; Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bouvet","sequence":"additional","affiliation":[{"name":"APHP, Service de Maladies Infectieuses et Tropicales, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Gault","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Bichat-Claude Bernard, Paris, France; Centre d'Investigation Clinique 1425-EC, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 Mixte de Recherche 1123, Epid\u00e9miologie Clinique et Evaluation Economique Appliqu\u00e9es aux Populations Vuln\u00e9rables, Paris , Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yazdanpanah","sequence":"additional","affiliation":[{"name":"APHP, Service de Maladies Infectieuses et Tropicales, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2017\/00000021\/00000012\/art00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:53:45Z","timestamp":1579737225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.17.0353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,1]]}},"alternative-id":["1027-3719(20171201)21:12L.1272;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.17.0353","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,1]]}}}