{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:11:29Z","timestamp":1787897489800,"version":"build-2784847793"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> Rio de Janeiro, RJ, Brazil, a high tuberculosis (TB) burden city.<jats:bold>OBJECTIVE:<\/jats:bold> To compare the sociodemographics, clinical characteristics, care process indicators (CPIs) and treatment outcomes among adolescents with pulmonary TB (PTB) and those with PTB + extrapulmonary\n TB (EPTB), who underwent testing with Xpert<jats:sup>\u00ae<\/jats:sup> and sputum culture.<jats:bold>DESIGN:<\/jats:bold> This was a retrospective study of data from three national databases from 2014 to 2016 of adolescents (aged 10\u201318 years) residing and notified in Rio de Janeiro City. Three groups were identified\n according to their Xpert and culture results: Group 1, Xpert- and culture-positive; Group 2, Xpert-positive and culture-negative; and Group 3, Xpert- and culture-negative. Study CPIs were as follows: the time between \u2018sample collection and Xpert result release', \u2018sample collection\n and treatment initiation' and \u2018notification and treatment outcome'.<jats:bold>RESULTS:<\/jats:bold> Of 258 adolescents included in the study, 223 (86.4%) were in Group 1, 20 (7.8%) in Group 2 and 15 (5.8%) in Group 3. Groups 1 and 2 had a similar profile. Compared to Group 1, Group 3 had a higher\n proportion of HIV-positive cases (21.4% vs. 3.0%, <jats:italic>P<\/jats:italic> = 0.016), adolescents with a hospital diagnosis (53.3% vs. 7.6%, <jats:italic>P<\/jats:italic> &lt; 0.001), and PTB + EPTB cases (20% vs. 0.4%; <jats:italic>P<\/jats:italic> &lt; 0.001). There were no statistically significant differences in CPIs or treatment outcomes.<jats:bold>CONCLUSION:<\/jats:bold>\n The clinical diagnosis was decisive in more critical or complex patients, despite Xpert-negative results.<\/jats:p>","DOI":"10.5588\/ijtld.18.0778","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:55:51Z","timestamp":1571446551000},"page":"1115-1121","source":"Crossref","is-referenced-by-count":7,"title":["Contribution of Xpert MTB\/RIF to clinical diagnosis in adolescents with tuberculosis in Rio de Janeiro, Brazil"],"prefix":"10.5588","volume":"23","author":[{"given":"M. C. B.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Postgraduate Programme in Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Sant'Anna","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Faculty of Medicine, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Federal University of Rio de Janeiro, Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. R.","family":"Luiz","sequence":"additional","affiliation":[{"name":"Social Medicine Institute, Federal University of Rio de Janeiro, Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. C. C.","family":"Soares","sequence":"additional","affiliation":[{"name":"Tuberculosis Programme, Secretaria Municipal de Sa\u00fade, Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Kritski","sequence":"additional","affiliation":[{"name":"Academic Programme of Tuberculosis, Institute of Thorax Diseases, Faculty of Medicine Hospital Universit\u00e1rio Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2019\/00000023\/00000010\/art00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:55:53Z","timestamp":1571446553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.18.0778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,1]]}},"alternative-id":["1027-3719(20191001)23:10L.1115;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.18.0778","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}