{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:58:38Z","timestamp":1765976318141},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> Early diagnosis of latent tuberculous infection (LTBI) should be pursued in healthcare workers (HCWs). While HCWs in hospitals are screened for LTBI, HCWs in outpatient settings are usually not. In 2017, in Italy, a tuberculosis (TB) infected paediatrician working in\n an outpatient vaccination service infected 15 adults and nine children. The investigation involved 2490 children and 151 adults. Among children, nine were tuberculin skin test-positive, and four developed active TB. Among 123 adult contacts with longer exposure, seven were interferon-gamma\n release assay (IGRA) positive and none had active TB. Among 28 close contacts, eight had a positive IGRA, and three had pulmonary TB. The total outbreak cost \u20ac1\u2009017\u2009903.<jats:bold>OBJECTIVE:<\/jats:bold> To compare the outbreak cost with those of potential screening programme strategies.<jats:bold>RESULTS:<\/jats:bold>\n Regular screening of paediatric outpatient HCWs would have cost between \u20ac2592 and \u20ac11\u2009373. Extending the screening to all outpatient HCWs (caring for adults and children) would have cost between \u20ac66\u2009384 and \u20ac155\u2009043. Investigating only close contacts\n would have cost \u20ac42\u2009857.<jats:bold>CONCLUSION:<\/jats:bold> Each of these screening strategies would have been cost-effective compared with the outbreak investigation occurring in real life with a cut-off of 474 for the maximum number of tested outpatient HCWs needed for the screening strategy\n to be cost-saving.<\/jats:p>","DOI":"10.5588\/ijtld.19.0060","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T04:37:59Z","timestamp":1571200679000},"page":"1024-1028","source":"Crossref","is-referenced-by-count":2,"title":["Tuberculosis screening in outpatient healthcare workers: lessons from a high-income, low TB burden country"],"prefix":"10.5588","volume":"23","author":[{"given":"S.","family":"Di Bella","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Siroka","sequence":"additional","affiliation":[{"name":"Global Tuberculosis Programme, World Health Organization (WHO), Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Antonello","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zignol","sequence":"additional","affiliation":[{"name":"Global Tuberculosis Programme, World Health Organization (WHO), Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Maschio","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di ricovero e cura a carattere scientifico (IRCCS) \u201cBo Garofolo\u201d, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tominz","sequence":"additional","affiliation":[{"name":"Department of Prevention, Local Health Authority and University of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, Division of Immunology and Infectious Diseases, San Raffaele Scientific Institute, San Raffaele Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Migliori","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for TB and Lung Disease, Maugeri Care and Research Institute, IRCCS, Tradate"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Confalonieri","sequence":"additional","affiliation":[{"name":"Pulmonology Unit, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Raviglione","sequence":"additional","affiliation":[{"name":"Global Health, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Luzzati","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Trieste, Trieste"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2019\/00000023\/00000009\/art00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T08:44:53Z","timestamp":1572338693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,1]]}},"alternative-id":["1027-3719(20190901)23:9L.1024;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0060","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,1]]}}}