{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T02:17:18Z","timestamp":1648865838389},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>We present the case of a 21-year-old man admitted to the intensive care unit with multi-organ failure due to multidrug-resistant tuberculosis (TB). TB treatment initially comprised moxifloxacin, ethambutol, linezolid and amikacin administered intravenously. Due to suspected moxifloxacin-induced\n liver injury, we stopped all fluoroquinolones and switched to bedaquiline (BDQ), which is only available in tablets for oral administration. Since our patient had to be fed through a nasogastric tube (NGT), BDQ was administered after being crushed and dissolved in water; drug pharmacokinetics\n were studied using repeated blood sampling. Therapeutic drug monitoring showed that BDQ was detectable in blood plasma with a trough concentration above the supposed efficacy threshold, suggesting that this molecule could be administered through NGT.<\/jats:p>","DOI":"10.5588\/ijtld.19.0221","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T05:25:17Z","timestamp":1580534717000},"page":"110-112","source":"Crossref","is-referenced-by-count":2,"title":["Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit"],"prefix":"10.5588","volume":"24","author":[{"given":"E.","family":"Dang","sequence":"first","affiliation":[{"name":"Laboratoire de Pharmacologie-Toxicologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sayagh","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dicale et infectieuse, H\u00f4pital Bichat-Claude Bernard, Assistance Publique-H\u00f4pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie-Toxicologie, Unit\u00e9 Mixte de Recherche 1137 Infection anti-microbien modelisation evolution, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Institut national de la sant\u00e9 et de la recherche\n m\u00e9dicale, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Neuville","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente, H\u00f4pital Foch, Suresnes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sinnah","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dicale et infectieuse, H\u00f4pital Bichat-Claude Bernard, Assistance Publique-H\u00f4pitaux de Paris, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-F.","family":"Timsit","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dicale et infectieuse, H\u00f4pital Bichat-Claude Bernard, Assistance Publique-H\u00f4pitaux de Paris, Paris, Unit\u00e9 Mixte de Recherche 1137 Infection anti-microbien modelisation evolution, Universit\u00e9\n Paris Diderot, Sorbonne Paris Cit\u00e9, Institut national de la sant\u00e9 et de la recherche m\u00e9dicale, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Peytavin","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie-Toxicologie, Unit\u00e9 Mixte de Recherche 1137 Infection anti-microbien modelisation evolution, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Institut national de la sant\u00e9 et de la recherche\n m\u00e9dicale, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000001\/art00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T04:55:19Z","timestamp":1581742519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["1027-3719(20200101)24:1L.110;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0221","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}