{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:37:24Z","timestamp":1763037444698},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> Tuberculosis (TB) incidence is declining overall in France, but not in Paris where some areas remain relative hot spots for TB.<jats:bold>OBJECTIVES:<\/jats:bold> To obtain a better knowledge of local TB epidemiology in order to facilitate control measures.<jats:bold>DESIGN:<\/jats:bold> Analysis\n of demographic data of TB patients diagnosed at the Bichat-Claude Bernard Hospital from 2007 to 2016, with spoligotyping of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> complex isolates.<jats:bold>RESULTS:<\/jats:bold> During the study period, 1096 TB patients were analysed. The incidence of TB diagnosis was stable,\n averaging 115 patients per year, predominantly males (71%), foreign-born (81%), with pulmonary TB (77%) and negative HIV serology (88%). The mean age of foreign-born TB patients decreased over the study period, most significantly in recent arrivals in France, whose average age decreased by\n two years (<jats:italic>P<\/jats:italic> = 0.001). The time period between arrival in France and being diagnosed with active TB decreased annually significantly by 0.75 years (<jats:italic>P<\/jats:italic> = 0.02). The proportion of L4.6.2\/Cameroon and L2\/Beijing sub-lineages increased annually by 0.7% (<jats:italic>P<\/jats:italic> &lt; 0.05). Multi-drug\n resistant strains, representing 4% of all strains, increased annually by 0.75% (<jats:italic>P<\/jats:italic> = 0.03)<jats:bold>CONCLUSION:<\/jats:bold> The number of TB patients remained high in northern Paris and the surrounding suburbs, suggesting the need for increased control measures.<\/jats:p>","DOI":"10.5588\/ijtld.19.0305","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:42:36Z","timestamp":1587530556000},"page":"428-435","source":"Crossref","is-referenced-by-count":5,"title":["Tuberculosis trends in a hot-spot region in Paris, France"],"prefix":"10.5588","volume":"24","author":[{"given":"C.","family":"Pierre-Audigier","sequence":"first","affiliation":[{"name":"Mycobacterial Genetics Unit, Institut Pasteur, Paris, Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center\n for Chronic Disease Control, Shenzhen, 518054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Talla","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-K.","family":"Alame-Emane","sequence":"additional","affiliation":[{"name":"Mycobacterial Genetics Unit, Institut Pasteur, Paris, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Audigier","sequence":"additional","affiliation":[{"name":"Statistic Study Group, Ecole Polytechnique, Palaiseau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Grall","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, IAME, UMR 1137, Institut national de la sant\u00e9 et de la recherche m\u00e9dicale, Universit\u00e9 Paris Diderot, Sorbonne Paris\n Cit\u00e9 F-75018, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ruimy","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire, Nice"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Andremont","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, IAME, UMR 1137, Institut national de la sant\u00e9 et de la recherche m\u00e9dicale, Universit\u00e9 Paris Diderot, Sorbonne\n Paris Cit\u00e9 F-75018, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cadet-Daniel","sequence":"additional","affiliation":[{"name":"Mycobacterial Genetics Unit, Institut Pasteur, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sola","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC), CEA, Centre national de la Recherche scientifique, Universit\u00e9 Paris Sud, Universit\u00e9 Paris Saclay, Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Takiff","sequence":"additional","affiliation":[{"name":"Mycobacterial Genetics Unit, Institut Pasteur, Paris, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas,\n Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gicquel","sequence":"additional","affiliation":[{"name":"Mycobacterial Genetics Unit, Institut Pasteur, Paris, Department of Tuberculosis Prevention and Control, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vray","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie des Maladies Infectieuses, Institut Pasteur, Dakar, Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Armand-Lefevre","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie, Centre Hospitalo-Universitaire Bichat-Claude Bernard, APHP, Paris, France, IAME, UMR 1137, Institut national de la sant\u00e9 et de la recherche m\u00e9dicale, Universit\u00e9 Paris Diderot, Sorbonne\n Paris Cit\u00e9 F-75018, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000004\/art00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:42:47Z","timestamp":1587530567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,1]]}},"alternative-id":["1027-3719(20200401)24:4L.428;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0305","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,1]]}}}