{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:05:54Z","timestamp":1790867154485,"version":"4.1.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> A referral hospital in South Africa.<jats:bold>OBJECTIVE:<\/jats:bold> To describe the clinical presentation, serial brain imaging findings during treatment and outcome of patients with intracranial tuberculoma in a high human immunodeficiency virus (HIV) prevalence setting.<jats:bold>DESIGN:<\/jats:bold>\n This was a retrospective observational study conducted over a 12.5-year period. Records of adults (age \u226518 years) who presented with neurological TB were screened. We included patients with tuberculoma in whom sequential brain imaging was performed.<jats:bold>RESULTS:<\/jats:bold> Of 66 patients enrolled,\n HIV status was known in 61; 47 (71%) were HIV-infected and 14 (21%) were non-HIV-infected. Clinical and imaging findings and outcomes were similar between these groups. Persistent tuberculoma was present at 18 months follow-up in 20\/41 (49%) patients who underwent repeat imaging at that timepoint;\n those with persistent tuberculoma were more likely to have persisting neurological abnormalities (85% vs. 52%; <jats:italic>P<\/jats:italic> = 0.043). Larger tuberculoma size at presentation (\u22653 cm) was the only factor significantly associated with tuberculoma persistence (multivariable logistic regression,\n OR 19.9, 95%CI 1.27\u2013309.68; <jats:italic>P<\/jats:italic> = 0.033).<jats:bold>CONCLUSION:<\/jats:bold> Tuberculoma is a severely disabling TB manifestation regardless of HIV coinfection, with half of patients showing radiologically persistent lesions at 18 months follow-up. Large size of tuberculoma at presentation heralds\n lower chance of its resolution within 18 months.<\/jats:p>","DOI":"10.5588\/ijtld.19.0386","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T04:39:41Z","timestamp":1583296781000},"page":"224-232","source":"Crossref","is-referenced-by-count":9,"title":["Presentation and outcome of patients with intracranial tuberculoma in a high HIV prevalence setting"],"prefix":"10.5588","volume":"24","author":[{"given":"S.","family":"Marais","sequence":"first","affiliation":[{"name":"Department of Neurology, Inkosi Albert Luthuli Central Hospital and University of KwaZulu-Natal, Durban, Division of Neurology E8-75, New Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inkosi Albert Luthuli Central Hospital and University of KwaZulu-Natal, Durban, Clinical Outcomes Research Unit, Department of Medicine, University of Melbourne, Melbourne, VIC, Department of Neurology, Royal Melbourne Hospital,\n Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mitha","sequence":"additional","affiliation":[{"name":"Department of Radiology, Inkosi Albert Luthuli Central Hospital, Cato Manor, Durban, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inkosi Albert Luthuli Central Hospital and University of KwaZulu-Natal, Durban"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kalincik","sequence":"additional","affiliation":[{"name":"Clinical Outcomes Research Unit, Department of Medicine, University of Melbourne, Melbourne, VIC, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Bhigjee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inkosi Albert Luthuli Central Hospital and University of KwaZulu-Natal, Durban"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000002\/art00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T04:39:43Z","timestamp":1583296783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,1]]}},"alternative-id":["1027-3719(20200201)24:2L.224;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0386","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,1]]}}}