{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:48:29Z","timestamp":1791938909334,"version":"4.3.4"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:<\/jats:bold> To document the level of drug resistance in MDR-TB patients and to characterize management capacities for their medical care and MDR-TB treatment outcomes in the Kharkiv region of Ukraine. This area has one of the highest frequencies of MDR-TB worldwide.<jats:bold>METHODS:<\/jats:bold>\n A retrospective observational cohort study was performed on registry data from the regional anti-TB dispensary in Kharkiv. All microbiologically confirmed MDR-TB patients registered in 2014 were included. Diagnostic, treatment and post-treatment follow-up data were analysed.<jats:bold>RESULTS:<\/jats:bold>\n Of 169 patients with MDR-TB, 55.0% had pre-extensively drug-resistant (pre-XDR) or XDR resistant patterns. Rapid molecular diagnosis by GeneXpert and liquid <jats:italic>M. tuberculosis<\/jats:italic> cultures were only available for 66.9% and 56.8% of patients, respectively. Phenotypic drug-susceptibility testing\n (DST) for high priority TB drugs (bedaquiline, linezolid, clofazimine) were not available. DST for later generation fluroquinolones was available only in 53.2% of patients. 50.9% of patients had less than 4 drugs in the treatment regimen proven to be effective by DST. More than 23.1% of patients\n with MDR-TB failed their treatment and only 45.0% achieved a cure.<jats:bold>CONCLUSION:<\/jats:bold> The high prevalence of MDR-TB and poor MDR-TB treatment outcomes in the Kharkiv region, is associated with substantial shortages in rapid molecular and phenotypic DST, a lack of high priority MDR-TB drugs,\n poor treatment monitoring and follow-up capacities.<\/jats:p>","DOI":"10.5588\/ijtld.19.0508","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T04:57:31Z","timestamp":1589345851000},"page":"485-491","source":"Crossref","is-referenced-by-count":21,"title":["Multidrug-resistant tuberculosis in the Kharkiv Region, Ukraine"],"prefix":"10.5588","volume":"24","author":[{"given":"D.","family":"Butov","sequence":"first","affiliation":[{"name":"Kharkiv National Medical University, Kharkiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lange","sequence":"additional","affiliation":[{"name":"Research Center Borstel, Clinical Infectious Diseases, Borstel, Germany, German Center for Infection Research (DZIF) Clinical Tuberculosis Unit, Borstel, Germany, Department of Internal Medicine, Karolinska Institute, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heyckendorf","sequence":"additional","affiliation":[{"name":"Research Center Borstel, Clinical Infectious Diseases, Borstel, Germany, German Center for Infection Research (DZIF) Clinical Tuberculosis Unit, Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kalmykova","sequence":"additional","affiliation":[{"name":"Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Butova","sequence":"additional","affiliation":[{"name":"VN Karazin Kharkiv National University, Kharkiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Borovok","sequence":"additional","affiliation":[{"name":"Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Novokhatskaya","sequence":"additional","affiliation":[{"name":"Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chesov","sequence":"additional","affiliation":[{"name":"Research Center Borstel, Clinical Infectious Diseases, Borstel, Germany, German Center for Infection Research (DZIF) Clinical Tuberculosis Unit, Borstel, Germany, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000005\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:34:24Z","timestamp":1625117664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["1027-3719(20200501)24:5L.485;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0508","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}