{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:09:55Z","timestamp":1692878995408},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Using 2004\u20132007 TB:HIV Study data&lt;x\/&gt; from Europe and Latin America, we previously generated a health care index (HCI) for TB and HIV co-infected people. With improvements in diagnostic and management practices, we have now updated the HCI with new data.<jats:bold>METHODS:<\/jats:bold>\n We evaluated nine aspects of health care in Cox proportional hazards models on time from TB diagnosis to death. Kaplan-Meier methods were used to estimate the probability of death by HCI quartile.<jats:bold>RESULTS:<\/jats:bold> Of 1396 eligible individuals (72% male, 59% from Eastern Europe), 269 died\n within 12 months. Use of rifamycin\/isoniazid\/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50\u20130.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST + &lt;3 drugs (HR 1.09, 95% CI 0.80\u20131.48), DST + \u22653 drugs (HR 0.49, 95% CI 0.35\u20130.70) vs. no DST),\n recent HIV-RNA measurement (HR 0.64, 95% CI 0.50\u20130.82) and combination antiretroviral therapy use (HR 0.72, 95% CI 0.53\u20130.97) were associated with mortality. These factors contributed respectively 5, \u20131, 8, 5 and 4 to the HCI&lt;x\/&gt;. Lower HCI was associated with an increased\n probability of death; 30% (95% CI 26\u201335) vs. 9% (95% CI 6\u201313) in the lowest vs. the highest quartile.&lt;x\/&gt;<jats:bold>CONCLUSION:<\/jats:bold> We found five potentially modifiable health care components that were associated with mortality among TB-HIV positive individuals. Validation of\n our HCI in other TB cohorts could enhance our findings.<\/jats:p>","DOI":"10.5588\/ijtld.19.0568","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T04:36:33Z","timestamp":1602304593000},"page":"956-962","source":"Crossref","is-referenced-by-count":1,"title":["A new health care index predicts short term mortality for TB and HIV co-infected people"],"prefix":"10.5588","volume":"24","author":[{"given":"A. O.","family":"Roen","sequence":"first","affiliation":[{"name":"University College London (UCL) Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Podlekareva","sequence":"additional","affiliation":[{"name":"CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Miller","sequence":"additional","affiliation":[{"name":"UCL Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, UCL London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mocroft","sequence":"additional","affiliation":[{"name":"University College London (UCL) Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Panteleev","sequence":"additional","affiliation":[{"name":"Department of HIV\/TB, TB Hospital 2, St Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Skrahina","sequence":"additional","affiliation":[{"name":"The Republican Scientific and Practical Center for Pulmonology and TB, Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Miro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Cayla","sequence":"additional","affiliation":[{"name":"Servicio de Epidemiolog\u00eda, Agencia de Salud P\u00fablica de Barcelona, CIBER Epidemiolog\u00eda y Salud P\u00fablica, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tetradov","sequence":"additional","affiliation":[{"name":"Dr Victor Babes\u00b4 Hospital of Tropical and Infectious Diseases, Bucharest, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Derisova","sequence":"additional","affiliation":[{"name":"Botkin Infectious Disease Hospital, St Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Furrer","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Losso","sequence":"additional","affiliation":[{"name":"Department of Immunocompromised, Hospital JM Ramos Mejia, Pabell\u00f3n de Clin\u00edca, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vassilenko","sequence":"additional","affiliation":[{"name":"Belarusian State Medical University, Minsk, Department of Infectious Diseases, City Clinical Hospital of Infectious Diseases, Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Girardi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ospedale L Spallanzani National Institute for Infectious Diseases, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"Post","sequence":"additional","affiliation":[{"name":"Kings College Hospital NHS Foundation Trust, London, UK; and the TB:HIV Study Group (complete list of study group listed in the Supplementary Data)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kirk","sequence":"additional","affiliation":[{"name":"CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000009\/art00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T04:31:48Z","timestamp":1602563508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["1027-3719(20200901)24:9L.956;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0568","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}