{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:25:24Z","timestamp":1770780324594,"version":"3.50.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Vitamin D deficiency is associated with progression of latent tuberculosis (TB) infection to active disease. The impact of preventive therapy on this association is unknown.<jats:bold>METHOD:<\/jats:bold> Serum 25-hydroxyvitamin D (25(OH)D) levels were retrospectively linked to\n adults diagnosed with latent TB between April 2010 and January 2019 in a hospital in London, UK. Individuals in the cohort who progressed to active TB were identified by matching to a national notification register. A logistic regression model was used to examine baseline vitamin D deficiency\n and use of preventive therapy with subsequent incidence of TB disease.<jats:bold>RESULTS:<\/jats:bold> Of 1509 latently infected individuals with 3902 patient-years of follow-up, 687 (45.5%) were identified as vitamin D deficient and 691 (45.8%) individuals had a LTBI regimen prescribed. There were 29\n (1.9%) instances of TB reactivation. On multivariate analysis, profound (&lt;25 nmol\/L) vitamin D deficiency (aHR 5.68, 95%CI 2.18\u201314.82; <jats:italic>P<\/jats:italic> = 0.0003) and the absence of preventive therapy (aHR 3.84, 95%CI 1.46\u201310.08; <jats:italic>P<\/jats:italic> = 0.006) were associated with progression to\n active TB disease. There was no evidence that preventive therapy modified the association between vitamin D status and TB reactivation.<jats:bold>CONCLUSION:<\/jats:bold> Our results show an independent association between vitamin D deficiency and progression from latent TB infection to active disease.<\/jats:p>","DOI":"10.5588\/ijtld.19.0605","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T04:36:33Z","timestamp":1602304593000},"page":"916-921","source":"Crossref","is-referenced-by-count":12,"title":["Vitamin D deficiency predicts latent TB reactivation independent of preventive therapy: a longitudinal study"],"prefix":"10.5588","volume":"24","author":[{"given":"B.","family":"Patterson","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Telford","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tana","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Northwick Park Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Martineau","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000009\/art00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T04:31:39Z","timestamp":1602563499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["1027-3719(20200901)24:9L.916;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0605","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}