{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:18:41Z","timestamp":1721711921288},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:<\/jats:bold> 1) To determine the prevalence of diabetes mellitus and impaired fasting glucose (IFG) in patients with TB and HIV co-infection, and 2) to investigate the effect of fasting plasma glucose (FPG) on rifampicin (RIF) and isoniazid (INH) serum concentrations.<jats:bold>DESIGN:<\/jats:bold>\n Retrospective data analysis of a cohort of HIV-infected adults with newly diagnosed pulmonary TB. Plasma glucose and TB drug levels were obtained at Week 0, 2, 8 and 24 of TB treatment.<jats:bold>RESULTS:<\/jats:bold> A total of 107 patients were included in this analysis. Random plasma glucose \u2265200\n mg\/dL was found in 1\/53 (2%) participant at Week 0. The prevalence of FPG \u2265 126 mg\/dL decreased from 8\/41 (20%) at Week 2 to 3\/89 (3%) at Week 24. IFG (100\u2013125 mg\/dL) was observed in 23\/41 (56%) participants at Week 2, and 39\/89 (44%) at Week 24. FPG was inversely correlated with\n lower area under the curve (AUC<jats:sub>0\u201324h<\/jats:sub>) for RIF (c = -0.52; 95%CI -0.84 to -0.21; <jats:italic>P<\/jats:italic> = 0.001). FPG was not associated with lower INH AUC<jats:sub>0\u201324h<\/jats:sub>.<jats:bold>CONCLUSION:<\/jats:bold> We found a high prevalence of FPG \u2265 126 mg\/dL, which decreased significantly\n during treatment, and a high proportion of IFG at the end of TB treatment. Higher FPG was associated with lower AUC for RIF.<\/jats:p>","DOI":"10.5588\/ijtld.19.0755","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T04:35:19Z","timestamp":1608006919000},"page":"1234-1240","source":"Crossref","is-referenced-by-count":1,"title":["Hyperglycaemia and pharmacokinetics of rifampicin\/isoniazid among TB-HIV co-infected patients in Kampala, Uganda"],"prefix":"10.5588","volume":"24","author":[{"given":"F.","family":"Wyrsch","sequence":"first","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"von Braun","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine and Infectious Diseases, University Hospital Leipzig, University of Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sekaggya-Wiltshire","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Haller","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ledergerber","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Musaazi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Fehr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Department of Public Health, Epidemiology, Infectious Diseases and Prevention Institute, University of Zurich, Zurich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kambugu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Castelnuovo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Tschopp","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000012\/art00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T04:35:30Z","timestamp":1608006930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.19.0755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["1027-3719(20201201)24:12L.1234;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.19.0755","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}