{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:29:45Z","timestamp":1772778585851,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p><jats:bold>OBJECTIVE:<\/jats:bold> To establish the diagnostic nomogram for tuberculous pleurisy (TP) based on TB-interferon-gamma release assays (TB-IGRA), as well as clinical and peripheral blood characteristics.<jats:bold>MATERIAL AND METHODS:<\/jats:bold> Patients who underwent TB-IGRA tests during hospitalisation\n and were finally diagnosed, were retrospectively and continuously enrolled. TP was divided into confirmed TP (cTP) and presumptive TP (pTP), and corresponding diagnostic nomograms were established.<jats:bold>RESULTS:<\/jats:bold> A total of 1283 patients were enrolled (median age 49 years, range 14\u201396;\n males: 63.1%). The area under the curve (AUC) of TB-IGRA was 0.81 (95%CI 0.77\u20130.84) for cTP (<jats:italic>n<\/jats:italic> = 272) and 0.74 (95%CI 0.71\u20130.78) for pTP (<jats:italic>n<\/jats:italic> = 644). The false-positive and negative rates of TB-IGRA among non-TP and cTP were respectively 32.4% and 16.8%. Based on LASSO\n analysis, we then selected respectively 12 and 10 predictors from clinical and peripheral blood characteristics to establish cTP and pTP nomograms (TB-IGRA was selected). The cTP and pTP nomograms had an AUC of 0.93 (95%CI 0.90\u20130.95) and 0.92 (95%CI 0.90\u20130.94) in the training group,\n and 0.91 (95%CI 0.87\u20130.96) and 0.93 (95%CI 0.89\u20130.96) in the validation group, respectively, which were superior to TB-IGRA test alone.<jats:bold>CONCLUSION:<\/jats:bold> Novel predictive nomograms with less invasiveness were provided based on TB-IGRA test to assist differential diagnosis of\n TP and non-TP patients.<\/jats:p>","DOI":"10.5588\/ijtld.20.0001","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T04:40:21Z","timestamp":1605069621000},"page":"1178-1185","source":"Crossref","is-referenced-by-count":3,"title":["Development and validation of novel diagnostic nomogram for tuberculous pleurisy based on TB-IGRA results"],"prefix":"10.5588","volume":"24","author":[{"given":"R.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Department of Lung Cancer Treatment Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000011\/art00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T04:43:01Z","timestamp":1606797781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["1027-3719(20201101)24:11L.1178;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0001","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}