{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:18:24Z","timestamp":1779027504756,"version":"3.51.4"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> To report the frequency and severity of complications, and their effect on the outcome of tuberculous meningitis (TBM).<jats:bold>METHODS:<\/jats:bold> In this retrospective cohort study, the following TBM complications were observed: status epilepticus (SE), hydrocephalus, paradoxical\n clinical worsening (PCW), hyponatremia, drug-induced hepatitis (DIH), infarction and mechanical ventilation (MV). These were recorded and correlated with stage of meningitis and outcome.<jats:bold>RESULTS:<\/jats:bold> A total of 144 patients with TBM (median age 26 years, range 12\u201375) were included.\n There were 76 (52.8%) females. The patients were in Stage I (<jats:italic>n<\/jats:italic> = 33), Stage II (<jats:italic>n<\/jats:italic> = 82) and Stage III (<jats:italic>n<\/jats:italic> = 29); 58 had definite TBM. Complications occurred in 128 (88.9%); complications included hydrocephalus (<jats:italic>n<\/jats:italic> = 58, 40.3%), hyponatremia (<jats:italic>n<\/jats:italic> = 70, 48.6%),\n infarction (<jats:italic>n<\/jats:italic> = 48, 33.3%), DIH (<jats:italic>n<\/jats:italic> = 42, 29.2%), SE (<jats:italic>n<\/jats:italic> = 16, 18.0%), MV (<jats:italic>n<\/jats:italic> = 43, 29.9%) and PCW (<jats:italic>n<\/jats:italic> = 24, 16.7%), with variable overlap. By 6 months, 33 patients had died. Death was related to PCW (<jats:italic>P<\/jats:italic> = 0.016), hyponatremia (<jats:italic>P<\/jats:italic> = 0.03), MV (<jats:italic>P<\/jats:italic>\n = 0.02), infarction (<jats:italic>P<\/jats:italic> = 0.03) and the number of complications. Except PCW, most complications occurred during the first month.<jats:bold>CONCLUSIONS:<\/jats:bold> In TBM, complications occurred in 128 (88.9%) patients, mainly in the early stages, with variable overlap. Infarction, PCW, hyponatremia\n and MV were predictive of poor outcome.<\/jats:p>","DOI":"10.5588\/ijtld.20.0036","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T04:40:21Z","timestamp":1605069621000},"page":"1194-1199","source":"Crossref","is-referenced-by-count":8,"title":["Complications of tuberculous meningitis and their effect on outcome in a tertiary care cohort"],"prefix":"10.5588","volume":"24","author":[{"given":"U. K.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, Vivekanand Poly Clinic and Institute of Medical Sciences, Lucknow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kalita","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, All India Institute of Medical Sciences, Rishikesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Health Informatics, SGPGIMS, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000011\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T04:43:08Z","timestamp":1606797788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["1027-3719(20201101)24:11L.1194;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0036","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}