{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:10:54Z","timestamp":1782972654533,"version":"3.54.5"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Bedaquiline (BDQ) has not been extensively studied among patients co-infected with HIV drug-resistant tuberculosis (DR-TB). We compared treatment outcomes in DR-TB patients treated with BDQ- and linezolid (LZD) containing regimens to historic controls treated with\n second-line injectable-containing regimens.<jats:bold>METHODS:<\/jats:bold> Retrospective cohort study of consecutive DR-TB patients initiated on BDQ- and LZD-containing regimens at a TB referral hospital in KwaZulu-Natal, South Africa. Participants were prospectively followed through 24 months for treatment\n outcome and adverse events. Outcomes were compared to a historic control cohort of DR-TB HIV patients enrolled at the same facility prior to BDQ introduction.<jats:bold>RESULTS:<\/jats:bold> Adult DR-TB patients initiating BDQ between January 2014 and November 2015 were enrolled (<jats:italic>n<\/jats:italic> = 151). The majority\n of patients were female (52%), HIV co-infected (77%) and on antiretroviral therapy (100%). End of treatment outcomes included cure (63%), TB culture conversion (83%), completion (0.7%), loss to follow-up (15%), treatment failure (5%), and death (17%). Compared to historic controls (<jats:italic>n<\/jats:italic>\n = 105), patients treated with BDQ experienced significantly higher TB culture conversion and cure, with significantly lower mortality. Adverse effects were common (92%), and most frequently attributed to LZD (24.1%). QT segment prolongation was common but without clinical sequelae.<jats:bold>CONCLUSION:<\/jats:bold>\n Treatment with BDQ- and LZD-containing regimens was associated with improved treatment outcomes and survival in DR-TB HIV patients.<\/jats:p>","DOI":"10.5588\/ijtld.20.0048","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T04:39:32Z","timestamp":1604119172000},"page":"1024-1031","source":"Crossref","is-referenced-by-count":33,"title":["Treatment outcomes in patients with drug-resistant TB-HIV co-infection treated with bedaquiline and linezolid"],"prefix":"10.5588","volume":"24","author":[{"given":"N.","family":"Padayatchi","sequence":"first","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, College of Health Sciences, Medical Research Council-Centre for the AIDS Program of Research in South Africa HIV-TB Pathogenesis and Treatment Research\n Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Congella, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bionghi","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Osman","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, College of Health Sciences, Medical Research Council-Centre for the AIDS Program of Research in South Africa HIV-TB Pathogenesis and Treatment Research\n Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Congella, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Naidu","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, College of Health Sciences, Medical Research Council-Centre for the AIDS Program of Research in South Africa HIV-TB Pathogenesis and Treatment Research\n Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Congella, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ndjeka","sequence":"additional","affiliation":[{"name":"National TB Programme, South African National Department of Health, Pretoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Master","sequence":"additional","affiliation":[{"name":"King DinuZulu Medical Complex, Sydenham, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C. M","family":"Brust","sequence":"additional","affiliation":[{"name":"Divisions of General Internal Medicine and Infectious Diseases, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, College of Health Sciences, Medical Research Council-Centre for the AIDS Program of Research in South Africa HIV-TB Pathogenesis and Treatment Research\n Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Congella, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ramjee","sequence":"additional","affiliation":[{"name":"Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, College of Health Sciences, Medical Research Council-Centre for the AIDS Program of Research in South Africa HIV-TB Pathogenesis and Treatment Research\n Unit, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Congella, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"O\u00b4Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000010\/art00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T04:47:03Z","timestamp":1607748423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,1]]}},"alternative-id":["1027-3719(20201001)24:10L.1024;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0048","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}