{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T22:31:21Z","timestamp":1724884281671},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Occupational exposure-related risk of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection has been reported for village doctors in China. This prospective study aims to estimate the infection acquisition in this key population.<jats:bold>METHODS:<\/jats:bold> At baseline, all village\n doctors registered in Zhongmu County were tested by QuantiFERON<jats:sup>\u00ae<\/jats:sup>-TB Gold In-Tube (QFT) and QuantiFERON<jats:sup>\u00ae<\/jats:sup>-TB Gold Plus (QFT-Plus) in parallel. Those negatives for either of the tests were retested to identify conversions at the 2-year follow-up investigation.<jats:bold>RESULTS:<\/jats:bold>\n A total of 367 eligible participants completed the 2-year follow-up survey with frequency of conversion of 5.0% (18\/361) for QFT and 6.1% (21\/343) for QFT-Plus. The agreement of follow-up results between the tests was 93.2% with a \u03ba coefficient of 0.43 (95%CI 0.20\u20130.65). Among\n QFT-Plus convertors, the difference between TB1 and TB2 tubes (TB2-TB1) was significantly increased as compared with baseline results (<jats:italic>P<\/jats:italic> = 0.039). Participants from the villages with occurrence of microbiologically confirmed pulmonary TB showed higher frequency of QFT conversions (11.0%\n vs. 3.2%, <jats:italic>P<\/jats:italic> = 0.011) and QFT-Plus conversions (12.3% vs. 4.4%, <jats:italic>P<\/jats:italic> = 0.027) than those from the villages without occurrence.<jats:bold>CONCLUSION:<\/jats:bold> Our results consistently suggest that capability on occupational protection and <jats:italic>M. tuberculosis<\/jats:italic> infection control should be\n improved in village doctors in China.<\/jats:p>","DOI":"10.5588\/ijtld.20.0153","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T04:35:19Z","timestamp":1608006919000},"page":"1241-1246","source":"Crossref","is-referenced-by-count":2,"title":["The acquisition of <i>Mycobacterium tuberculosis<\/i> infection in village doctors in China: a prospective study"],"prefix":"10.5588","volume":"24","author":[{"given":"H.","family":"Zhang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Cao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Disease Prevention and Control of Zhongmu County, Zhengzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Xin","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Disease Prevention and Control of Zhongmu County, Zhengzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Disease Prevention and Control of Zhongmu County, Zhengzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Feng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Quan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Du","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[{"name":"The Sixth People\u00b4s Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Guan","sequence":"additional","affiliation":[{"name":"The Sixth People\u00b4s Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Shen","sequence":"additional","affiliation":[{"name":"The Sixth People\u00b4s Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Guan","sequence":"additional","affiliation":[{"name":"The Sixth People\u00b4s Hospital of Zhengzhou, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Jin","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pan","sequence":"additional","affiliation":[{"name":"Center for Disease Prevention and Control of Zhongmu County, Zhengzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung 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