{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:47:20Z","timestamp":1761965240693},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p>Rapid diagnostics, newer drugs, repurposed medications, and shorter regimens have radically altered the landscape for treating rifampicin-resistant TB (RR-TB) and multidrug-resistant TB (MDR-TB). There are multiple ongoing clinical trials aiming to build a robust evidence base to guide\n RR\/MDR-TB treatment, and both observational studies and programmatic data have contributed to advancing the treatment field. In December 2019, the WHO issued their second \u2018Rapid Communication\u00b4 related to RR-TB management. This reiterated their prior recommendation that a majority\n of people with RR\/MDR-TB receive all-oral treatment regimens, and now allow for specific shorter duration regimens to be used programmatically as well. Many TB programs need clinical advice as they seek to roll out such regimens in their specific setting. In this Perspective, we highlight\n our early experiences and lessons learned from working with National TB Programs, adult and pediatric clinicians and civil society, in optimizing treatment of RR\/MDR-TB, using shorter, highly-effective, oral regimens for the majority of people with RR\/MDR-TB.<\/jats:p>","DOI":"10.5588\/ijtld.20.0330","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T23:40:21Z","timestamp":1605051621000},"page":"1134-1144","source":"Crossref","is-referenced-by-count":7,"title":["Clinical perspectives on treatment of rifampicin-resistant\/multidrug-resistant TB"],"prefix":"10.5588","volume":"24","author":[{"given":"V.","family":"Cox","sequence":"first","affiliation":[{"name":"Center for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, Soauth Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Treatment Action Group, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Acquah","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res (MSF), Khayelitsha, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Reuter","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res (MSF), Khayelitsha, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of\n Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vambe","sequence":"additional","affiliation":[{"name":"Eswatini National TB Control Programme, Manzini, Eswatini"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ustero","sequence":"additional","affiliation":[{"name":"Global TB Program, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Udwadia","sequence":"additional","affiliation":[{"name":"Hinduja Hospital & Research Centre, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Trivi\u00f1o-Duran","sequence":"additional","affiliation":[{"name":"MSF, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tommasi","sequence":"additional","affiliation":[{"name":"Independent Consultant, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Skrahina","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and TB, Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Seddon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Imperial College London, UK, and Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Tygerberg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rodolfo","sequence":"additional","affiliation":[{"name":"National Department of Health, Mahikeng, North West Province, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rich","sequence":"additional","affiliation":[{"name":"Partners In Health (PIH), Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Padanilam","sequence":"additional","affiliation":[{"name":"National Department of Health, Johannesburg, Gauteng Province, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Oyewusi","sequence":"additional","affiliation":[{"name":"PIH, Maseru, Lesotho"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ohler","sequence":"additional","affiliation":[{"name":"MSF, Eshowe, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lungu","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Programme, Ministry of Health, Lusaka, Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Loveday","sequence":"additional","affiliation":[{"name":"Health Systems Research Unit, South African Medical Research Council, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Interactive Research and Development, Karachi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Khan","sequence":"additional","affiliation":[{"name":"Interactive Research and Development, Karachi, Pakistan, and Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hewison","sequence":"additional","affiliation":[{"name":"MSF, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Guglielmetti","sequence":"additional","affiliation":[{"name":"MSF, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Furin","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2020\/00000024\/00000011\/art00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T23:43:04Z","timestamp":1606779784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["1027-3719(20201101)24:11L.1134;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0330","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}