{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:45:16Z","timestamp":1768531516955,"version":"3.49.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Exposure to people with TB substantially elevates a person's risk of tuberculous infection and TB disease. Systematic screening of TB contacts enables the early detection and treatment of co\u2010prevalent disease, and the opportunity to prevent future TB disease.\n However, scale\u2010up of contact investigation in high TB transmission settings remains limited.<jats:bold>METHODS:<\/jats:bold> We undertook a narrative review to evaluate the evidence for contact investigation and identify strategies that TB programmes may consider when introducing contact investigation\n and management.<jats:bold>RESULTS:<\/jats:bold> Selection of contacts for priority screening depends upon their proximity and duration of exposure, along with their susceptibility to develop TB. Screening algorithms can be tailored to the target population, the availability of diagnostic tests and preventive\n therapy, and healthcare worker expertise. Contact investigation may be performed in the household or at communal locations. Local contact investigation policies should support vulnerable patients, and ensure that drop\u2010out during screening can be mitigated. Ethical issues should be anticipated\n and addressed in each setting.<jats:bold>CONCLUSION:<\/jats:bold> Contact investigation is an important strategy for TB elimination. While its epidemiological impact will be greatest in lower\u2010transmission settings, the early detection and prevention of TB have important benefits for contacts and\n their communities.<\/jats:p>","DOI":"10.5588\/ijtld.20.0658","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T14:25:25Z","timestamp":1613658325000},"page":"95-105","source":"Crossref","is-referenced-by-count":9,"title":["Active case\u2010finding in contacts of people with TB"],"prefix":"10.5588","volume":"25","author":[{"given":"G. J.","family":"Fox","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School, University of Sydney, Sydney, NSW, Woolcock Institute of Medical Research, Glebe, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Johnston","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, Glebe, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Majumdar","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, VIC, Centre for International Child Health, Department of Paediatrics University of Melbourne and Murdoch Children's Research Institute, Melbourne, VIC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Denholm","sequence":"additional","affiliation":[{"name":"Doherty Institute, University of Melbourne, Melbourne, VIC, Victorian Tuberculosis Program, Melbourne Health, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Asldurf","sequence":"additional","affiliation":[{"name":"School of Epidemiology & Public Health, University of Ottawa, Ottawa, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, Glebe, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B.","family":"Marks","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, Glebe, NSW, Australia, South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Velen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School, University of Sydney, Sydney, NSW, Woolcock Institute of Medical Research, Glebe, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2021\/00000025\/00000002\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T04:40:07Z","timestamp":1616560807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["1027-3719(20210201)25:2L.95;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0658","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}