{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:00:42Z","timestamp":1775271642878,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> Indoor volatile organic compound (VOC) levels, which are generally correlated with each other, may have an additive or synergistic effect on health. VOC synergy with allergens is a suspected mechanism affecting respiration.<jats:bold>OBJECTIVE:<\/jats:bold> To determine the effect\n of exposure to interactions between VOCs and allergens on respiratory symptoms in individuals aged \u226515 years.<jats:bold>DESIGN:<\/jats:bold> A national cross\u2010sectional survey measured 20 VOCs and dog and cat aeroallergens in 490 main residential dwellings in France. A standardised questionnaire\n was used to elicit responses on respiratory conditions in 1012 inhabitants. Four VOC factor scores (linear combinations of VOCs) were generated using principal component analysis. In order to take into account the phenomenon of multi\u2010pollution, marginal models were used to model the\n relationships between exposure to VOC mixture and respiratory conditions. Stratified models were used to examine the interaction between allergens and VOCs.<jats:bold>RESULTS:<\/jats:bold> The aromatic hydrocarbon score was associated with rhinitis and wheezing, the aliphatic hydrocarbon score with asthma\n and cough, the halogenated hydrocarbons with asthma, wheezing and rhinitis. Aldehydes and <jats:italic>Can f1<\/jats:italic> had a significant synergistic effect on wheezing and rhinitis. Aliphatic hydrocarbons had an antagonist effect with <jats:italic>Can f1<\/jats:italic> on wheezing.<jats:bold>CONCLUSION:<\/jats:bold> Our data support evidence\n of adverse effects of exposure to VOC mixture on respiratory conditions; this effect is aggravated in the presence of pet allergens.<\/jats:p>","DOI":"10.5588\/ijtld.20.0796","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T09:42:09Z","timestamp":1620812529000},"page":"350-357","source":"Crossref","is-referenced-by-count":4,"title":["Indoor pet allergen exposures modify the effects of chemical air pollutants on respiratory symptoms"],"prefix":"10.5588","volume":"25","author":[{"given":"N.","family":"Ba\u00efz","sequence":"first","affiliation":[{"name":"\u00c9pid\u00e9miologie des maladies Allergiques et Respiratoires, Institut Pierre Louis d\u00b4\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne University and Institut national de la sant\u00e9 et de la recherche m\u00e9dicale,\n Saint Antoine Medical School, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Billionnet","sequence":"additional","affiliation":[{"name":"\u00c9pid\u00e9miologie des maladies Allergiques et Respiratoires, Institut Pierre Louis d\u00b4\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne University and Institut national de la sant\u00e9 et de la recherche m\u00e9dicale,\n Saint Antoine Medical School, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kirchner","sequence":"additional","affiliation":[{"name":"F-77420, Observatoire de la qualit\u00e9 de l\u00b4air int\u00e9rieur, Centre Scientifique et Technique du B\u00e2timent, Paris Est University, Champs sur Marne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"de Blay","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de pneumologie, d\u00b4allergologie et de pathologie respiratoire de l\u00b4environnement des H\u00f4pitaux universitaires de Strasbourg, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Annesi-Maesano","sequence":"additional","affiliation":[{"name":"\u00c9pid\u00e9miologie des maladies Allergiques et Respiratoires, Institut Pierre Louis d\u00b4\u00c9pid\u00e9miologie et de Sant\u00e9 Publique, Sorbonne University and Institut national de la sant\u00e9 et de la recherche\n m\u00e9dicale, Saint Antoine Medical School, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2021\/00000025\/00000005\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T09:42:16Z","timestamp":1620812536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,1]]}},"alternative-id":["1027-3719(20210501)25:5L.350;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0796","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,1]]}}}