{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:40:27Z","timestamp":1791614427757,"version":"4.3.4"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Persistent respiratory symptoms and lung function deficits are common after patients with TB. We aimed to define the burden of post-TB lung disease (PTLD) and assess associations between symptoms and impairment in two high TB incidence communities.<jats:bold>METHODS:<\/jats:bold>\n This was a cross-sectional survey of adults in Cape Town, South Africa who completed TB treatment 1\u20135 years previously. Questionnaires, spirometry and 6-minute walking distance (6MWD) were used to assess relationships between outcome measures and associated factors.<jats:bold>RESULTS:<\/jats:bold>\n Of the 145 participants recruited (mean age: 42 years, range: 18\u201375; 55 [38%] women), 55 (38%) had airflow obstruction and 84 (58%) had low forced vital capacity (FVC); the mean 6MWD was 463 m (range: 240\u2013723). Respiratory symptoms were common: chronic cough (<jats:italic>n<\/jats:italic> = 27, 19%),\n wheeze (<jats:italic>n<\/jats:italic> = 61, 42%) and dyspnoea (modified MRC dyspnoea score 3 or 4: <jats:italic>n<\/jats:italic> = 36, 25%). There was poor correlation between FVC or obstruction and 6MWD. Only low body mass index showed consistent association with outcomes on multivariable analyses. Only 19 (13%) participants had\n a diagnosis of respiratory disease, and 16 (11%) currently received inhalers.<jats:bold>CONCLUSION:<\/jats:bold> There was substantial burden of symptoms and physiological impairment in this \u201ccured\u201d population, but poor correlation between objective outcome measures, highlighting deficits in\n our understanding of PTLD.<\/jats:p>","DOI":"10.5588\/ijtld.20.0906","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T04:30:32Z","timestamp":1616646632000},"page":"262-270","source":"Crossref","is-referenced-by-count":42,"title":["Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function"],"prefix":"10.5588","volume":"25","author":[{"given":"B. W.","family":"Allwood","sequence":"first","affiliation":[{"name":"Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stolbrink","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Baines","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Louw","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. T.","family":"Wademan","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lupton-Smith","sequence":"additional","affiliation":[{"name":"Department of Science and Innovation-National Research Foundation South African Centre for Excellence in Epidemiological Modelling and Analysis (SACEMA), Faculty of Science, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nel","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, School of Medicine, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Maree","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Hospital, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mpagama","sequence":"additional","affiliation":[{"name":"Kibong\u00b4oto Infectious Diseases Hospital, Kilimanjaro, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Osman","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M.","family":"Marx","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, Department of Science and Innovation-National Research Foundation South African Centre\n for Excellence in Epidemiological Modelling and Analysis (SACEMA), Faculty of Science, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hoddinott","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lesosky","sequence":"additional","affiliation":[{"name":"Division of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, South Africa, Liverpool School of Tropical Medicine, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rylance","sequence":"additional","affiliation":[{"name":"Lung Health Group, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, Liverpool School of Tropical Medicine, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mortimer;","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"on behalf of the Lung health in Africa across","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2021\/00000025\/00000004\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:34:54Z","timestamp":1625117694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.20.0906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["1027-3719(20210401)25:4L.262;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.20.0906","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}