{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:26:08Z","timestamp":1768537568389,"version":"3.49.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Diagnostic delay and drug resistance not only worsen the outcomes of tuberculous meningitis (TBM), but are also important impediments to TB elimination efforts. Given the need for a near point-of-care test suitable for primary healthcare centres and simultaneous detection\n of resistance, Truenat\u2122 MTB Plus assay was evaluated on a large cohort of TBM patients.<jats:bold>METHODS:<\/jats:bold> Truenat assay was performed on 148 cerebrospinal fluid specimens (76 definite TBM, 32 probable TBM and 40 non-TBM controls) and its performance was compared with Xpert<jats:sup>\u00ae<\/jats:sup>\n Ultra.<jats:bold>RESULTS:<\/jats:bold> The overall sensitivity of Truenat and Ultra was respectively 78.7% and 67.6% in diagnosing TBM, and respectively 85.5% and 96% in diagnosing definite TBM. Twenty-three additional cases were detected using Truenat and 11 using Ultra. Truenat missed seven cases of\n rifampicin (RIF) resistance and indicated false RIF resistance in four cases.<jats:bold>CONCLUSION:<\/jats:bold> Performance of Truenat was comparable to that of Ultra in diagnosing TBM and inferior to Xpert Ultra in determining RIF resistance.<\/jats:p>","DOI":"10.5588\/ijtld.21.0156","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T04:41:56Z","timestamp":1627706516000},"page":"626-631","source":"Crossref","is-referenced-by-count":34,"title":["Comparative analysis of Truenat\u2122 MTB Plus and Xpert<sup>\u00ae<\/sup> Ultra in diagnosing tuberculous meningitis"],"prefix":"10.5588","volume":"25","author":[{"given":"K.","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, Department of Microbiology, All India Institute of Medical Sciences, Bilaspur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineChandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal MedicineChandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, PGIMER, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2021\/00000025\/00000008\/art00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T04:41:59Z","timestamp":1627706519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.21.0156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,1]]}},"alternative-id":["1027-3719(20210801)25:8L.626;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.21.0156","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,1]]}}}