{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:14:56Z","timestamp":1661231696017},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Rapid diagnosis of drug-resistant TB is critical for early initiation of effective therapy. YD Diagnostics in South Korea recently developed the MolecuTech<jats:sup>\u00ae<\/jats:sup> REBA MTB-XMDR test to rapidly detect multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant\n TB (pre-XDR-TB) and resistance to second-line injectable drugs (SLIDs) simultaneously using a fully automated test platform. This study aimed to evaluate the MolecuTech<jats:sup>\u00ae<\/jats:sup> test for the detection of MDR- and pre-XDR-TB, as well as SLID resistance.<jats:bold>METHODS:<\/jats:bold> A total of\n 151 clinical <jats:italic>Mycobacterium tuberculosis<\/jats:italic> isolates from South Korea were tested using the MolecuTech test, and the results were analysed by comparing these with phenotypic drug susceptibility testing (pDST) and sequencing.<jats:bold>RESULTS:<\/jats:bold> Compared to pDST, the MolecuTech test showed\n a sensitivity and specificity of respectively 97.7% and 100.0% for rifampicin (RIF), 82.4% and 100.0% for isoniazid (INH), 97.5% and 97.2% for fluoroquinolones (FQs), and 94.0% and 98.8% for SLIDs. Concordances with the sequencing results of each resistance determinant were 99.3% for RIF,\n 96.7% for INH, 98.7% for FQs and 99.3% for SLIDs.<jats:bold>CONCLUSION:<\/jats:bold> The MolecuTech test is an efficient and reliable rapid molecular diagnostic tool for the simultaneous screening of MDR- and pre-XDR-TB.<\/jats:p>","DOI":"10.5588\/ijtld.21.0606","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:34:53Z","timestamp":1661229293000},"page":"869-874","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the MolecuTech<sup>\u00ae<\/sup> REBA MTB-XMDR kit for detection of pre-extensively drug-resistant TB"],"prefix":"10.5588","volume":"26","author":[{"given":"E. J.","family":"Cho","sequence":"first","affiliation":[{"name":"International Tuberculosis Research Center, Gyeongsangnam-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Kang","sequence":"additional","affiliation":[{"name":"YD Diagnostics, Gyeonggi-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"YD Diagnostics, Gyeonggi-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea, Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Lee","sequence":"additional","affiliation":[{"name":"International Tuberculosis Research Center, Gyeongsangnam-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Son","sequence":"additional","affiliation":[{"name":"International Tuberculosis Research Center, Gyeongsangnam-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Park","sequence":"additional","affiliation":[{"name":"YD Diagnostics, Gyeonggi-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea, College of Pharmacy, Dongguk University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W.","family":"Aung","sequence":"additional","affiliation":[{"name":"Advanced Molecular Research Centre, Department of Medical Research, Yangon, Myanmar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"International Tuberculosis Research Center, Gyeongsangnam-do, College of Health Sciences, Catholic University of Pusan, Busan, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000009\/art00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:35:09Z","timestamp":1661229309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.21.0606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["1027-3719(20220901)26:9L.869;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.21.0606","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}