{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T07:28:56Z","timestamp":1786260536818,"version":"build-2736575974"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Protection against infection by the bacille Calmette-Gu\u00e9rin vaccine against <jats:italic>Mycobacterium tuberculosis<\/jats:italic> remains a subject of controversy. We investigated the association between BCG vaccination at birth and infection by <jats:italic>M. tuberculosis<\/jats:italic>.<jats:bold>MATERIAL\n and METHODS:<\/jats:bold> This was a secondary analysis of data from tuberculin skin test (TST) surveys in Vietnamese schoolchildren between 1988 and 2001. We investigated whether a BCG scar was associated with a lower prevalence of TST positivity, adjusting for BCG-induced variation by varying cut-off\n values for a positive TST.<jats:bold>RESULTS:<\/jats:bold> We found a positive association between BCG scar and TST positivity. The strength of the association decreased with increasing TST cut-off values; however, it never inverted significantly, irrespective of geographic region and survey year.<jats:bold>CONCLUSION:<\/jats:bold>\n In Vietnam, BCG vaccination was not associated with reduced <jats:italic>M. tuberculosis<\/jats:italic> infection prevalence as measured using TST. This in contrary to a similar study conducted in Tanzania. These contradictory findings may be explained by geographical differences and the relatively high prevalence\n in Vietnam of the <jats:italic>M. tuberculosis<\/jats:italic> Beijing genotype, which is reported to be capable of circumventing BCG-induced immunity.<\/jats:p>","DOI":"10.5588\/ijtld.21.0607","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T09:46:56Z","timestamp":1657619216000},"page":"529-536","source":"Crossref","is-referenced-by-count":6,"title":["Does BCG vaccination protect against infection with <i>M. tuberculosis<\/i>?"],"prefix":"10.5588","volume":"26","author":[{"given":"P. T.","family":"Pelzer","sequence":"first","affiliation":[{"name":"KNCV Tuberculosis foundation, Technical division, The Hague, The Netherlands, Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Smit","sequence":"additional","affiliation":[{"name":"KNCV Tuberculosis foundation, Technical division, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.W.","family":"Tiemersma","sequence":"additional","affiliation":[{"name":"KNCV Tuberculosis foundation, Technical division, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. T.","family":"Huong","sequence":"additional","affiliation":[{"name":"NTP Vietnam, National Lung Hospital, Hanoi, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. V.","family":"Nhung","sequence":"additional","affiliation":[{"name":"KNCV Tuberculosis Foundation, Country office in Vietnam, Hanoi, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cobelens","sequence":"additional","affiliation":[{"name":"Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000006\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T09:47:15Z","timestamp":1657619235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.21.0607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"alternative-id":["1027-3719(20220601)26:6L.529;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.21.0607","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}