{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:14:42Z","timestamp":1791332082441,"version":"4.3.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> We assessed treatment uptake and completion for 6 months of isoniazid (6H) and 3 months of isoniazid plus rifapentine weekly (3HP) in a programmatic setting in Pakistan.<jats:bold>METHODS:<\/jats:bold> All household contacts were clinically evaluated to rule out TB disease. 6H\n was used for TB preventive treatment (TPT) from October 2016 to April 2017; from May to September 2017, 3HP was used for contacts aged \u22652 years. We compared clinical evaluation, TPT uptake and completion rates between contacts aged \u22652 years in the 6H period and in the 3HP period.<jats:bold>RESULTS:<\/jats:bold>\n We identified 3,442 contacts for the 6H regimen. After clinical evaluation, 744\/1,036 (72%) started treatment, while 46% completed treatment. In contrast, 3,722 contacts were identified for 3HP. After clinical evaluation, 990\/1,366 (72%) started treatment, while 67% completed treatment. Uptake\n of TPT did not differ significantly between the 6H and 3HP groups (OR 1.03, 95%CI 0.86\u20131.24). However, people who initiated 3HP had 2.3 times greater odds (95% CI 1.9\u20132.8) of completing treatment than those who initiated 6H after adjusting for age and sex.<jats:bold>CONCLUSION:<\/jats:bold>\n In programmatic settings in a high-burden country, household contacts of all ages were more likely to complete TPT with shorter weekly regimens, although treatment uptake rate for the two regimens was similar.<\/jats:p>","DOI":"10.5588\/ijtld.21.0676","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:18:05Z","timestamp":1658985485000},"page":"741-746","source":"Crossref","is-referenced-by-count":18,"title":["Implementing 3HP vs. IPT as TB preventive treatment in Pakistan"],"prefix":"10.5588","volume":"26","author":[{"given":"M.","family":"Jaswal","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Farooq","sequence":"additional","affiliation":[{"name":"TB Control Programme, The Indus Hospital and Health Network, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Madhani","sequence":"additional","affiliation":[{"name":"Programmes Unit, Aga Khan Health Services, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Noorani","sequence":"additional","affiliation":[{"name":"Monitoring & Evaluation, Public Health England, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Salahuddin","sequence":"additional","affiliation":[{"name":"TB Control Programme, The Indus Hospital and Health Network, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Amanullah","sequence":"additional","affiliation":[{"name":"TB Control Programme, The Indus Hospital and Health Network, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Khowaja","sequence":"additional","affiliation":[{"name":"TB Department, Interactive Research and Development (IRD) Global, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Safdar","sequence":"additional","affiliation":[{"name":"TB Department, Interactive Research and Development (IRD) Global, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khan","sequence":"additional","affiliation":[{"name":"TB Department, Interactive Research and Development (IRD) Global, Singapore, TB Department, Harvard Medical School, Boston, MA, Infectious Diseases, Harvard Medical School Center for Global Health Delivery, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yuen","sequence":"additional","affiliation":[{"name":"TB Department, Harvard Medical School, Boston, MA, Infectious Diseases, Harvard Medical School Center for Global Health Delivery, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Keshavjee","sequence":"additional","affiliation":[{"name":"TB Department, Harvard Medical School, Boston, MA, Infectious Diseases, Harvard Medical School Center for Global Health Delivery, Boston, MA, TB Department, Partners In Health, Boston, MA, Infectious Diseases, Brigham and Women\u00b4s Hospital,\n Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Becerra","sequence":"additional","affiliation":[{"name":"TB Department, Harvard Medical School, Boston, MA, Infectious Diseases, Harvard Medical School Center for Global Health Delivery, Boston, MA, TB Department, Partners In Health, Boston, MA, Infectious Diseases, Brigham and Women\u00b4s Hospital,\n Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hussain","sequence":"additional","affiliation":[{"name":"TB Department, Interactive Research and Development (IRD) Global, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Malik","sequence":"additional","affiliation":[{"name":"TB Department, Interactive Research and Development (IRD) Global, Singapore, Internal Medicine, Yale School of Medicine, New Haven, CT, Yale Institute for Global Health, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000008\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:18:27Z","timestamp":1658985507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.21.0676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"alternative-id":["1027-3719(20220801)26:8L.741;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.21.0676","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,1]]}}}