{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:46:23Z","timestamp":1759340783293},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> Multidrug-resistant TB (MDR-TB) clinical trial in Lima, Peru and Cape Town, South Africa.<jats:bold>OBJECTIVE:<\/jats:bold> To identify baseline factors associated with screening failure and study withdrawal in an MDR-TB clinical trial.<jats:bold>DESIGN:<\/jats:bold> We screened patients for\n a randomized, blinded, Phase II trial which assessed culture conversion over the first 6 months of treatment with varying doses of levofloxacin plus an optimized background regimen (ClinicalTrials.gov: NCT01918397). We identified factors for screening failure and study withdrawal using Poisson\n regression to calculate prevalence ratios and Cox proportional hazard regression to calculate hazard ratios. We adjusted for factors with <jats:italic>P<\/jats:italic> &lt; 0.2.<jats:bold>RESULTS:<\/jats:bold> Of the 255 patients screened, 144 (56.5%) failed screening. The most common reason for screening failure was an unsuitable\n resistance profile on sputum-based molecular susceptibility testing (<jats:italic>n<\/jats:italic> = 105, 72.9%). No significant baseline predictors of screening failure were identified in the multivariable model. Of the 111 who were enrolled, 33 (30%) failed to complete treatment, mostly for non-adherence and\n consent withdrawal. No baseline factors predicted study withdrawal in the multivariable model.<jats:bold>CONCLUSION:<\/jats:bold> No baseline factors were independently associated with either screening failure or study withdrawal in this secondary analysis of a MDR-TB clinical trial.<\/jats:p>","DOI":"10.5588\/ijtld.21.0729","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:34:53Z","timestamp":1661229293000},"page":"820-825","source":"Crossref","is-referenced-by-count":1,"title":["Factors associated with screening failure and study withdrawal in multidrug-resistant TB"],"prefix":"10.5588","volume":"26","author":[{"given":"A.","family":"Schwalb","sequence":"first","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cachay","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Vanderbilt Tuberculosis Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. P. J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"University of California San Francisco Center for Tuberculosis, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kaur","sequence":"additional","affiliation":[{"name":"Boston University, Departments of Epidemiology, Biostatistics, Global Health and Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Diacon","sequence":"additional","affiliation":[{"name":"TASK Applied Science and Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ugarte-Gil","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Mitnick","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. R.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Vanderbilt Tuberculosis Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gotuzzo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Horsburgh","sequence":"additional","affiliation":[{"name":"Boston University, Departments of Epidemiology, Biostatistics, Global Health and Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000009\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T04:35:03Z","timestamp":1661229303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.21.0729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["1027-3719(20220901)26:9L.820;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.21.0729","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}