{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:51:55Z","timestamp":1771275115390,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> TB caused by rifampicin-resistant (RR) and multidrug-resistant (MDR) <jats:italic>Mycobacterium tuberculosis<\/jats:italic> strains is a major concern to TB control globally. However, in the European Union, MDR-TB notifications among all bacteriologically confirmed TB cases with available\n drug susceptibility testing (DST) results decreased over the last years.<jats:bold>METHODS:<\/jats:bold> We conducted a retrospective analysis on DST results reported from 2011 to 2020 by 46 laboratories in 19 out of 20 regions in Italy in order to evaluate resistance trends to first- and second-line drugs\n in MDR\/RR-TB strains isolated from Italian-born persons (IBPs) and foreign-born persons (FBPs).<jats:bold>RESULTS:<\/jats:bold> Of 23,972 <jats:italic>M. tuberculosis<\/jats:italic> strains examined (15,519 from FBPs and 8,453 from IBPs), MDR-TB decreased from 3.2% in 2011 to 2.2% in 2020. High MDR\/RR-TB rates occurred mostly\n in FBPs from former Soviet Union countries. In 2017, a MDR\/RR-TB increase was detected in FBPs from sub-Saharan Africa. MDR-TB strains showed consistent increase in resistance to pyrazinamide (PZA), slight increase in resistance to fluoroquinolones and a decrease in resistance to other drugs.<jats:bold>CONCLUSION:<\/jats:bold>\n While MDR\/RR-TB cases slightly decreased, a worrisome increase of resistance to PZA and fluoroquinolones among MDR\/RR-TB patients was seen. This implies that a fast and efficient diagnosis aligned with therapy is crucial for TB control.<\/jats:p>","DOI":"10.5588\/ijtld.22.0050","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:18:05Z","timestamp":1658985485000},"page":"775-783","source":"Crossref","is-referenced-by-count":2,"title":["Decreasing trend of drug-resistant TB in Italy"],"prefix":"10.5588","volume":"26","author":[{"given":"F.","family":"Giannoni","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lanni","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Iacobino","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Borroni","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fattorini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"the Italian Multicentre Study on Resistance t","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000008\/art00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:18:07Z","timestamp":1658985487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.22.0050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"alternative-id":["1027-3719(20220801)26:8L.775;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.22.0050","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,1]]}}}