{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:12:07Z","timestamp":1770729127838,"version":"3.49.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Children under 1 year of age with hypoxic pneumonia regularly have concurrent cytomegalovirus (CMV) viremia. In these children, the diagnosis of CMV-associated pneumonia and the prediction of an outcome are difficult. It is unclear whether quantification of blood\n CMV viral load (CMV-VL) can predict outcomes in these children.<jats:bold>METHODS:<\/jats:bold> This was a retrospective study including children (1\u201312 months of age), with detectable CMV-VL and hypoxic pneumonia admitted to the paediatric intensive care unit of Tygerberg Hospital, Cape Town, South\n Africa between 1 January 2014 and 31 December 2015. Clinical, radiological and biochemical data were collected.<jats:bold>RESULTS:<\/jats:bold> Of the 87 participants included (median age: 3.9 months, IQR 2.2\u20134.8), 35 were (40%) born prematurely. The median weight-for-age <jats:italic>Z<\/jats:italic>-score was \u20132.68\n (IQR \u20133.0 to \u20130.83); 37 (43%) were severely underweight for age; 27 (31%) were HIV-positive, 3 were on ART. The median CMV-VL was log 4.0 (IQR 3.3\u20134.79); CMV<jats:sub>high<\/jats:sub> was defined as CMV-VL &gt; median; CMV-VL &lt; median was classified as CMV<jats:sub>low<\/jats:sub>. Overall\n survival was 90%; 12 (15.4%) remained oxygen-dependent at Day 28 post-admission. There was no difference in survival, 24-h post-admission ratio of arterial oxygen partial pressure to fractional inspired oxygen (P<jats:sub>a<\/jats:sub>O<jats:sub>2<\/jats:sub>:F<jats:sub>i<\/jats:sub>O<jats:sub>2<\/jats:sub>), oxygen dependence or ventilation\n duration between CMV<jats:sub>low<\/jats:sub> and CMV<jats:sub>high<\/jats:sub>. High-frequency oscillation ventilation duration was longer (<jats:italic>P<\/jats:italic> = 0.005) and Pneumocystis jirovecii (PJP) co-infection more frequent (<jats:italic>P<\/jats:italic> = 0.018) in CMV<jats:sub>high<\/jats:sub>.<jats:bold>CONCLUSION:<\/jats:bold> CMV-VL is unable to predict the\n clinical outcome in children with hypoxic pneumonia. Specific treatment for CMV should be considered in all children at risk of CMV-associated pneumonia with detectable CMV-VL.<\/jats:p>","DOI":"10.5588\/ijtld.22.0428","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:35:10Z","timestamp":1673498110000},"page":"49-54","source":"Crossref","is-referenced-by-count":4,"title":["Cytomegalovirus viral load as predictor of the clinical course of hypoxic pneumonia in children"],"prefix":"10.5588","volume":"27","author":[{"given":"A.","family":"Lakhan","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gie","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rhode","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mfingwana","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Goussard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000001\/art00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:35:34Z","timestamp":1673498134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.22.0428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"alternative-id":["1027-3719(20230101)27:1L.49;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.22.0428","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}