{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:32:44Z","timestamp":1780061564352,"version":"3.54.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Drug-resistant TB (DR-TB) remains a significant public health burden and a threat to the progress made in TB control and prevention in sub-Saharan Africa.<jats:bold>OBJECTIVE:<\/jats:bold> To determine the risk-predictors of poor treatment outcomes in patients with DR-TB in Uganda.<jats:bold>METHODS:<\/jats:bold>\n We retrospectively reviewed medical records of adult Ugandans who had been treated for DR-TB at Mbarara Regional Referral Hospital (MRRH) in Uganda.<jats:bold>RESULTS:<\/jats:bold> Of the 385 files reviewed, 332 (86.2%) met the study inclusion criteria. Of these, 226 (68.1%) were men and 193 (58.1%) were\n HIV-positive. A total of 73 participants (22.7%) had unfavorable treatment outcomes (treatment failure, loss to follow-up or death). History of cigarette smoking (OR 5.10, 95% CI 2.4\u201311.4; <jats:italic>P<\/jats:italic> &lt; 0.001), age &gt;60 years (OR 6.32, 95% CI 2.2\u201318.6; <jats:italic>P<\/jats:italic> &lt; 0.001), anemia\n (OR 2.38, 95% CI 1.1\u20135.3; <jats:italic>P<\/jats:italic> = 0.02) and thrombocytopenia (OR 3.60, 95% CI 1.6\u20138.1; <jats:italic>P<\/jats:italic> &lt; \u20040.001) were independent predictors of unfavorable treatment outcomes.<jats:bold>CONCLUSION:<\/jats:bold> There is a high prevalence of unfavorable treatment outcomes among patients\n with DR-TB. Further research is required to design a prognostic model for DR-TB patients in a resource-limited setting.<\/jats:p>","DOI":"10.5588\/ijtld.22.0638","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T09:42:30Z","timestamp":1681119750000},"page":"291-297","source":"Crossref","is-referenced-by-count":8,"title":["Unfavorable treatment outcomes among patients with drug-resistant TB in Uganda"],"prefix":"10.5588","volume":"27","author":[{"given":"T. M.","family":"Kintu","sequence":"first","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. S.","family":"Mwanahamisi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Muwanguzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kyagambiddwa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Miiro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tishekwa","sequence":"additional","affiliation":[{"name":"Tuberculosis Treatment Unit, Mbarara Regional Referral Hospital, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J. D.","family":"Lodiong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Timbiine","sequence":"additional","affiliation":[{"name":"Tuberculosis Treatment Unit, Mbarara Regional Referral Hospital, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tumukunde","sequence":"additional","affiliation":[{"name":"Tuberculosis Treatment Unit, Mbarara Regional Referral Hospital, Mbarara, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Baluku","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Kiruddu National Referral Hospital, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nuwagira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda, Tuberculosis Treatment Unit, Mbarara Regional Referral Hospital, Mbarara, Uganda, Department of Medicine, Division of Infectious Diseases and International\n health, University of Virginia, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000004\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:36:17Z","timestamp":1681187777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.22.0638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["1027-3719(20230401)27:4L.291;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.22.0638","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,1]]}}}