{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:12:56Z","timestamp":1793103176799,"version":"4.5.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p><jats:bold>SETTING:<\/jats:bold> According to reports in South Africa, treatment failure rates for rifampicin-resistant TB (RR-TB) are significant and below the WHO target of \u226570%. HIV infection and the use of highly active antiretroviral therapy (HAART) influence how patients receiving anti-TB drugs\n respond to therapy. In the treatment of RR-TB, more recent medications, including bedaquiline, pretomanid and linezolid (BPaL), have shown promising results.<jats:bold>OBJECTIVE:<\/jats:bold> To assess treatment outcomes in RR-TB patients using BPaL and other second-line anti-TB drugs as recommended by\n the WHO in the South African population.<jats:bold>DESIGN:<\/jats:bold> The databases Medline, PubMed, Google Scholar and Embase were searched for studies between 2015 and 2022, which investigated BPaL outcomes in South Africa.<jats:bold>RESULTS:<\/jats:bold> Of the 27,259 participants, 21% were on bedaquiline, 1%\n were taking pretomanid and 9% were taking linezolid as part of their background regimen. About 68% of the patients were HIV-positive, with 59% of them taking HAART.<jats:bold>CONCLUSION:<\/jats:bold> Overall, 66% of patients taking BPaL drugs as part of their background regimen had favourable treatment\n outcomes. Additionally, patients with RR-TB who were HIV-positive and taking HAART while receiving BPaL drugs as part of a background regimen had improved treatment outcomes.<\/jats:p>","DOI":"10.5588\/ijtld.22.0649","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T04:31:00Z","timestamp":1690345860000},"page":"599-605","source":"Crossref","is-referenced-by-count":7,"title":["Favourable outcomes in RR-TB patients using BPaL and other WHO-recommended second-line anti-TB drugs"],"prefix":"10.5588","volume":"27","author":[{"given":"M. C.","family":"Rikhotso","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E.","family":"Ledwaba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-P. K.","family":"Ngandu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mavumengwana","sequence":"additional","affiliation":[{"name":"Department of Science and Innovation - National Research FoundationCentre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human\n Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South African Medical Research Council Genomics Centre, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Kinnear","sequence":"additional","affiliation":[{"name":"Department of Science and Innovation - National Research FoundationCentre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics,\n Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South African Medical Research Council Genomics Centre, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Science and Innovation - National Research FoundationCentre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics,\n Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South African Medical Research Council Genomics Centre, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Potgieter","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000008\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:33:38Z","timestamp":1692851618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.22.0649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["1027-3719(20230801)27:8L.599;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.22.0649","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,1]]}}}