{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:28:03Z","timestamp":1781821683034,"version":"3.54.5"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p><jats:bold>BACKGROUND:<\/jats:bold> Spirometry is considered relevant for the diagnosis and monitoring of post-TB lung disease. However, spirometry is rarely done in newly diagnosed TB patients.<jats:bold>METHODS:<\/jats:bold> Newly diagnosed, microbiologically confirmed TB patients were recruited for the study.\n Spirometry was performed within 21 days of TB treatment initiation according to American Thoracic Society\/European Respiratory Society guidelines. Spirometry analysis was done using Global Lung Initiative equations for standardisation.<jats:bold>RESULTS:<\/jats:bold> Of 1,430 eligible study participants,\n 24.7% (353\/1,430) had no spirometry performed mainly due to contraindications and 23.0% (329\/1,430) had invalid results; 52.3% (748\/1,430) of participants had a valid result, 82.8% (619\/748) of whom had abnormal spirometry. Of participants with abnormal spirometry, 70% (436\/619) had low forced\n vital capacity (FVC), 6.1% (38\/619) had a low ratio of forced expiratory volume in 1 sec (FEV<jats:sub>1<\/jats:sub>) to FVC, and 19.1% (118\/619) had low FVC, as well as low FEV<jats:sub>1<\/jats:sub>\/FVC ratio. Among those with abnormal spirometry, 26.3% (163\/619) had severe lung impairment.<jats:bold>CONCLUSIONS:<\/jats:bold>\n In this population, a high proportion of not performed and invalid spirometry assessments was observed; this was addressed by removing tachycardia as a (relative) contraindication from the study guidance and retraining. The high proportion of patients with severe pulmonary impairment at the\n time of TB diagnosis suggests a huge morbidity burden and calls for further longitudinal studies on the relevance of spirometry in predicting chronic lung impairment after TB.<\/jats:p>","DOI":"10.5588\/ijtld.23.0040","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:35:13Z","timestamp":1698294913000},"page":"850-857","source":"Crossref","is-referenced-by-count":6,"title":["Performance of spirometry assessment at TB diagnosis"],"prefix":"10.5588","volume":"27","author":[{"given":"A.","family":"Rachow","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bakuli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Khosa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, Marracuene, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Nhassengo","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade, Marracuene, Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Owolabi","sequence":"additional","affiliation":[{"name":"Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jayasooriya","sequence":"additional","affiliation":[{"name":"Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. E.","family":"Ntinginya","sequence":"additional","affiliation":[{"name":"Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sabi","sequence":"additional","affiliation":[{"name":"Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rassool","sequence":"additional","affiliation":[{"name":"Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bennet","sequence":"additional","affiliation":[{"name":"Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Niemann","sequence":"additional","affiliation":[{"name":"Leibniz Lung Center, Research Center Borstel, Borstel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-M.","family":"Mekota","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Allwood","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Medicine Stellenbosch University and Tygerberg Hospital, Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Wallis","sequence":"additional","affiliation":[{"name":"The Aurum Institute, Johannesburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Charalambous","sequence":"additional","affiliation":[{"name":"The Aurum Institute, Johannesburg, Department of Medicine, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hoelscher","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Churchyard","sequence":"additional","affiliation":[{"name":"The Aurum Institute, Johannesburg, Department of Medicine, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000011\/art00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T04:35:32Z","timestamp":1698294932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.23.0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["1027-3719(20230801)27:11L.850;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.23.0040","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,1]]}}}