{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T04:24:27Z","timestamp":1743740667070},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<sec id=\"st1\"><title>OBJECTIVE<\/title>To describe the characteristics of people indicated for directly observed treatment (DOT) in Spain, and the factors associated with unsuccessful treatment.<\/sec><sec id=\"st2\"><title>METHODS<\/title>This\n was a multicentre observational study based on a prospective follow-up of patients over 18 years old diagnosed with TB between 2006 and 2019 from the registry of the Programa Integrado de Investigaci\u00f3n en Tuberculosis (PII-TB). Sociodemographic and clinical variables were collected.\n Adjusted odds ratios (aORs) were calculated for the indication of DOT and for having an unsuccessful treatment.<\/sec><sec id=\"st3\"><title>RESULTS<\/title>A total of 7,883 patients were included. The indication of DOT was associated with being homeless (aOR 5.93,\n 95% CI 3.03\u201311.59), inactivity status (aOR 2.55, 95% CI 2.02\u20133.23), alcohol consumption (aOR 1.94, 95% CI 1.51\u20132.48), parenteral drug use (aOR 1.77, 95% CI 1.06\u20132.95) and HIV diagnosis (aOR 1.96, 95% CI 1.16\u20133.29). Unsuccessful treatment was associated with having\n an HIV diagnosis (aPR 2.31, 95% CI 1.31\u20134.08), having a worse clinical and radiological evolution (clinical progression: APR 15.59, 95% CI 8.21\u201329.60; radiological progression: aPR 12.84, 95% CI 6.46\u201325.52), need for hospitalisation (aPR 1.73, 95% CI 1.10\u20132.73), unsatisfactory\n tolerability (aPR 2.82, 95% CI 1.49\u20135.29), the existence of difficulties in understanding the prescribed treatment (aPR 1.92, 95% CI 1.21\u20133.06), as well as worse treatment satisfaction (aPR 7.27, 95% CI 4.32\u201312.24).<\/sec><sec id=\"st4\"><title>CONCLUSION<\/title>The\n prioritisation of vulnerable populations is a key aspect to carry out the new Global Plan to End TB 2023\u20132030. In these groups DOT indication should be increased to ensure adherence and patient follow-up and outcomes.<\/sec><\/jats:p>","DOI":"10.5588\/ijtld.23.0396","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T04:30:51Z","timestamp":1714019451000},"page":"237-242","source":"Crossref","is-referenced-by-count":1,"title":["Factors associated with referrals for directly observed treatment and unsuccessful treatment"],"prefix":"10.5588","volume":"28","author":[{"given":"Y.D. Gonz\u00e1lez","family":"Diaz","sequence":"first","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Palma","sequence":"additional","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona, Servei d\u2019Epidemiologia, Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vargas-Legu\u00e1s","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona, Ag\u00e8ncia de Salut P\u00fablica de Barcelona, Servei d\u2019Epidemiologia, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Programa Integrado de Investigaci\u00f3n en Tuberculosis (PII-TB) de la Sociedad Espa\u00f1ola de Neumolog\u00eda y\n Cirug\u00eda Tor\u00e1cica (SEPAR), Barcelona, Fundaci\u00f3n Unidad de Investigaci\u00f3n en Tuberculosis (fuiTB), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Molina-Pinargorte","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Casas","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Forcada","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Santiago","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Altet","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-P.","family":"Millet","sequence":"additional","affiliation":[{"name":"Serveis Cl\u00ednics, Barcelona, Ag\u00e8ncia de Salut P\u00fablica de Barcelona, Servei d\u2019Epidemiologia, Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP),\n Madrid, Programa Integrado de Investigaci\u00f3n en Tuberculosis (PII-TB) de la Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica (SEPAR), Barcelona, Fundaci\u00f3n Unidad de Investigaci\u00f3n en Tuberculosis (fuiTB), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2024\/00000028\/00000005\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T04:30:55Z","timestamp":1714019455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.23.0396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["1027-3719(20240501)28:5L.237;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.23.0396","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}