{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:19:38Z","timestamp":1785194378670,"version":"3.55.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<sec><title>BACKGROUND<\/title>Treatment outcomes and long-term survival of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in a real-world setting are difficult to assess, especially for species other than Mycobacterium avium<\/jats:italic> complex (MAC).<\/sec><sec><title>METHODS<\/title>This\n was a retrospective cohort study on all Croatian residents with respiratory NTM isolates from 2006 to 2015, with follow-up to 2020.<\/sec><sec><title>RESULTS<\/title>Therapy was started in 98\/137 (71.5%) of patients, significantly more often in patients with fibrocavitary\n disease and\/or sputum smear positivity. Unsuccessful treatment outcomes were recorded in 39\/98 (39.8%) patients (14 deaths and 25 treatment failures). One-year and 5-year all-cause mortality were respectively 18.2% and 37.6%. Guideline-based treatment (GBT) was started in 50\/98 (51%) of treated\n patients and followed for the recommended duration in 35.7% (35\/98). This resulted in a higher chance of cure (OR 3.79, 95% CI 1.29 to 11.1; P<\/jats:italic> = 0.012) than inadequately treated\/untreated patients. For Mycobacterium xenopi<\/jats:italic> disease, high cure rates (>80%) were achieved both\n with GBT and non-GBT treatment regimens.<\/sec><sec><title>CONCLUSION<\/title>Guideline-based therapy resulted in a four-time higher chance of being cured. The impact of GBT on treatment outcomes was clear for MAC disease, but no apparent effect was observed for\n patients with M. xenopi<\/jats:italic> disease.<\/sec><\/jats:p>","DOI":"10.5588\/ijtld.24.0068","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:30:57Z","timestamp":1727483457000},"page":"482-487","source":"Crossref","is-referenced-by-count":7,"title":["Nationwide evaluation of treatment outcomes and survival of patients with non-tuberculous mycobacterial pulmonary disease"],"prefix":"10.5588","volume":"28","author":[{"given":"M.J.","family":"Makek","sequence":"first","affiliation":[{"name":"University of Zagreb, School of Medicine, Zagreb, Croatia;, Department for Respiratory Diseases, University Hospital Centre Zagreb, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Glodic","sequence":"additional","affiliation":[{"name":"Department for Respiratory Diseases, University Hospital Centre Zagreb, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sabol","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Laboratory of Molecular Virology and Bacteriology, Ruder Boskovic Institute, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zmak","sequence":"additional","affiliation":[{"name":"University of Zagreb, School of Medicine, Zagreb, Croatia;, National Mycobacteria Reference Laboratory, Croatian National Institute of Public Health, University of Zagreb, School of Medicine, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Samarzija","sequence":"additional","affiliation":[{"name":"University of Zagreb, School of Medicine, Zagreb, Croatia;, Department for Respiratory Diseases, University Hospital Centre Zagreb, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sola","sequence":"additional","affiliation":[{"name":"Special Hospital for Respiratory Diseases Rockefellerova, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marusic","sequence":"additional","affiliation":[{"name":"Department for Radiology, University Hospital Centre Zagreb, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Marekovic","sequence":"additional","affiliation":[{"name":"University of Zagreb, School of Medicine, Zagreb, Croatia;, Department of Clinical and Molecular Microbiology, University Hospital Centre, University of Zagreb, School of Medicine, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Bulat","sequence":"additional","affiliation":[{"name":"Department for Respiratory Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Corak","sequence":"additional","affiliation":[{"name":"Department for Respiratory Diseases, University Hospital Centre Zagreb, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Obrovac","sequence":"additional","affiliation":[{"name":"National Mycobacteria Reference Laboratory, Croatian National Institute of Public Health, University of Zagreb, School of Medicine, Zagreb, Croatia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van Ingen","sequence":"additional","affiliation":[{"name":"Radboud Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2024\/00000028\/00000010\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:35:19Z","timestamp":1757997319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.24.0068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["1027-3719(20241001)28:10L.482;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.24.0068","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,1]]}}}